公开(公告)号：US5597571A

公开(公告)日：1997-01-28

申请号：US484387

申请日：1995-06-07

Applicant: James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

Inventor： James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N15/30 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/012

CPC classification number: C12N15/70 ,  C07K14/455 ,  C07K16/20 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  Y10S530/822

Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

Abstract translation: 本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。 本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

公开(公告)号：US06969602B1

公开(公告)日：2005-11-29

申请号：US09838382

申请日：2001-04-20

Applicant: Harry D. Danforth ,  M. Aggie Fernando ,  John R. Barta

Inventor： Harry D. Danforth ,  M. Aggie Fernando ,  John R. Barta

IPC: A61K39/00 ,  A61K39/002 ,  A61K39/012 ,  A61K39/38 ,  C12N1/10 ,  G01N33/53

CPC classification number: A61K39/012 ,  A61K2039/522 ,  A61K2039/542 ,  A61K2039/552 ,  Y10S530/822

Abstract: An immunovariant strain of Eimeria maxima was isolated. Vaccines incorporating the immunovariant strain are effective in eliciting immunological protection against coccidial infection.

Abstract translation: 分离出最佳艾美球虫的免疫变异株。 结合免疫变异菌株的疫苗在引发针对球虫感染的免疫保护方面是有效的。

公开(公告)号：US5122471A

公开(公告)日：1992-06-16

申请号：US308219

申请日：1989-02-09

Applicant: Mark C. Jenkins ,  Hyun S. Lillehoj ,  John B. Dame ,  Harry D. Danforth ,  Michael D. Ruff

Inventor： Mark C. Jenkins ,  Hyun S. Lillehoj ,  John B. Dame ,  Harry D. Danforth ,  Michael D. Ruff

IPC: A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N1/21

CPC classification number: C07K14/455 ,  C07K16/20 ,  A61K39/00

Abstract: Disclosed are DnA sequences which code for antigenic proteins, methods for identifying such DNA sequences, and antigens coded for by such DNA sequences.The first step of the method is to provide a multiplicity of DNA sequences. These sequences are then inserted into DNA expression vectors to form recombinant expression vectors. The expression vectors are inserted into suitable hosts to form transformants which express the DNA sequences. The transformants are then contacted with antibodies directed against Eimeria antigens to identify transformants containing DNA sequences which code for Eimeria antigens. These antigens are then produced from the DNA sequences identified as coding for the antigens. The antigens so produced are contacted with white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein, to thereby identify DNA sequences which code for antigens that induce a cell-mediated immune response to avian coccidiosis.The DNA sequences of the present invention comprise cloned genes or fragments thereof that code on expression for an antigenic protein that activates white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein.

Abstract translation: 公开了编码抗原蛋白质的DnA序列，鉴定此类DNA序列的方法和由该DNA序列编码的抗原。 该方法的第一步是提供多个DNA序列。 然后将这些序列插入DNA表达载体中以形成重组表达载体。 将表达载体插入合适的宿主中以形成表达DNA序列的转化体。 然后将转化体与针对艾美球虫抗原的抗体接触，以鉴定含有编码艾美球虫抗原的DNA序列的转化体。 然后从鉴定为编码抗原的DNA序列产生这些抗原。 这样产生的抗原与影响细胞介导的免疫应答的白细胞接触，白血球对抗原性艾美球虫蛋白致敏，从而鉴定编码诱导细胞介导的免疫应答的抗原的DNA序列 球虫病 本发明的DNA序列包含编​​码激活影响细胞介导的免疫应答的白细胞的抗原性蛋白质的表达的克隆基因或其片段，所述白细胞对抗原性艾美球虫蛋白致敏。

公开(公告)号：US5279960A

公开(公告)日：1994-01-18

申请号：US879137

申请日：1992-05-05

Applicant: David M. Anderson ,  Russell J. McCandliss ,  Susan L. Strausberg ,  Robert L. Strausberg ,  Michael D. Ruff ,  Harry D. Danforth ,  Patricia C. Augustine

Inventor： David M. Anderson ,  Russell J. McCandliss ,  Susan L. Strausberg ,  Robert L. Strausberg ,  Michael D. Ruff ,  Harry D. Danforth ,  Patricia C. Augustine

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/012 ,  C07K15/04 ,  C12N15/30 ,  C12N15/67

CPC classification number: C07K14/455 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  C12N2830/002 ,  C12N2830/15 ,  Y10S530/822

Abstract: A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.

Abstract translation: 克隆的基因或其片段编码与针对禽类球虫抗原蛋白的单克隆或多价抗体结合的抗原蛋白。

公开(公告)号：US06767546B1

公开(公告)日：2004-07-27

申请号：US09931033

申请日：2001-08-17

Applicant: Patricia C. Allen ,  Mark Anderson ,  Harry D. Danforth

Inventor： Patricia C. Allen ,  Mark Anderson ,  Harry D. Danforth

IPC: A61K3578

CPC classification number: A61K39/39 ,  A23K10/30 ,  A23K50/75 ,  A61K36/28 ,  A61K39/012 ,  A61K2300/00

Abstract: Echinacea dietary supplements are useful adjuvants for live anticoccidial vaccines. Feed supplementation with Echinacea preparations enhances the immune response to such vaccines. Echinacea purpurea in amounts of about 0.1% to 0.5% administered for about two weeks to day-old chicks has been found effective for providing significant weight gain compared to vaccination alone.

Abstract translation: 紫锥菊膳食补充剂是活抗球虫疫苗的有用佐剂。 补充松果菊制剂的饲料增强了对这种疫苗的免疫应答。 已经发现与给予单独的疫苗接种相比，以约0.1％至0.5％的量施用大约两周至日龄小鸡的紫锥菊有效提供显着的体重增加。

公开(公告)号：US5482709A

公开(公告)日：1996-01-09

申请号：US148432

申请日：1993-11-08

Applicant: James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

Inventor： James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N15/30 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/012

CPC classification number: C12N15/70 ,  C07K14/455 ,  C07K16/20 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  Y10S530/822

Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

Abstract translation: 本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。 本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

公开(公告)号：US5273901A

公开(公告)日：1993-12-28

申请号：US581693

申请日：1990-09-12

Applicant: James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

Inventor： James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N15/30 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/12 ,  C07K15/04

CPC classification number: C12N15/70 ,  C07K14/455 ,  C07K16/20 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  Y10S530/822

Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

Abstract translation: 本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。 本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

公开(公告)号：US5709862A

公开(公告)日：1998-01-20

申请号：US148279

申请日：1993-11-08

Applicant: David M. Anderson ,  Russell J. McCandliss ,  Susan Lee Strausberg ,  Robert L. Strausberg ,  Michael D. Ruff ,  Harry D. Danforth ,  Patricia C. Augustine

Inventor： David M. Anderson ,  Russell J. McCandliss ,  Susan Lee Strausberg ,  Robert L. Strausberg ,  Michael D. Ruff ,  Harry D. Danforth ,  Patricia C. Augustine

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/002 ,  A61K39/012

CPC classification number: C07K14/455 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  C12N2830/002 ,  C12N2830/15 ,  Y10S530/822

Abstract: A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.

Abstract translation: 克隆的基因或其片段编码与针对禽类球虫抗原蛋白的单克隆或多价抗体结合的抗原蛋白。

公开(公告)号：US5656485A

公开(公告)日：1997-08-12

申请号：US691454

申请日：1996-08-02

Applicant: James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan Lee Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

Inventor： James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan Lee Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N15/30 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/012

CPC classification number: C12N15/70 ,  C07K14/455 ,  C07K16/20 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  Y10S530/822

Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.