公开(公告)号：US5482709A

公开(公告)日：1996-01-09

申请号：US148432

申请日：1993-11-08

Applicant: James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

Inventor： James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N15/30 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/012

CPC classification number: C12N15/70 ,  C07K14/455 ,  C07K16/20 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  Y10S530/822

Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

Abstract translation: 本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。 本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

公开(公告)号：US5273901A

公开(公告)日：1993-12-28

申请号：US581693

申请日：1990-09-12

Applicant: James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

Inventor： James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N15/30 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/12 ,  C07K15/04

CPC classification number: C12N15/70 ,  C07K14/455 ,  C07K16/20 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  Y10S530/822

Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

Abstract translation: 本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。 本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

公开(公告)号：US5763493A

公开(公告)日：1998-06-09

申请号：US667239

申请日：1996-06-21

Applicant: Michael D. Ruff ,  Sanvasi R. Kalidindi ,  Joel Elmore Sutton, Jr.

Inventor： Michael D. Ruff ,  Sanvasi R. Kalidindi ,  Joel Elmore Sutton, Jr.

IPC: A61K9/20 ,  A61K9/48 ,  A61K31/135 ,  A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A01N37/18 ,  A61K31/165

CPC classification number: A61K31/135 ,  A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/22 ,  A61K9/2013 ,  A61K9/4858

Abstract: This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.

Abstract translation: 本申请公开了一种抑制固体药物制剂中抗抑郁药物安非他酮降解的方法，使药物制剂在一年后维持其初始安非他酮效力的至少80％。

公开(公告)号：US5709862A

公开(公告)日：1998-01-20

申请号：US148279

申请日：1993-11-08

Applicant: David M. Anderson ,  Russell J. McCandliss ,  Susan Lee Strausberg ,  Robert L. Strausberg ,  Michael D. Ruff ,  Harry D. Danforth ,  Patricia C. Augustine

Inventor： David M. Anderson ,  Russell J. McCandliss ,  Susan Lee Strausberg ,  Robert L. Strausberg ,  Michael D. Ruff ,  Harry D. Danforth ,  Patricia C. Augustine

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/002 ,  A61K39/012

CPC classification number: C07K14/455 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  C12N2830/002 ,  C12N2830/15 ,  Y10S530/822

Abstract: A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.

Abstract translation: 克隆的基因或其片段编码与针对禽类球虫抗原蛋白的单克隆或多价抗体结合的抗原蛋白。

公开(公告)号：US5656485A

公开(公告)日：1997-08-12

申请号：US691454

申请日：1996-08-02

Applicant: James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan Lee Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

Inventor： James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan Lee Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N15/30 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/012

CPC classification number: C12N15/70 ,  C07K14/455 ,  C07K16/20 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  Y10S530/822

Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

公开(公告)号：US5279960A

公开(公告)日：1994-01-18

申请号：US879137

申请日：1992-05-05

Applicant: David M. Anderson ,  Russell J. McCandliss ,  Susan L. Strausberg ,  Robert L. Strausberg ,  Michael D. Ruff ,  Harry D. Danforth ,  Patricia C. Augustine

Inventor： David M. Anderson ,  Russell J. McCandliss ,  Susan L. Strausberg ,  Robert L. Strausberg ,  Michael D. Ruff ,  Harry D. Danforth ,  Patricia C. Augustine

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/012 ,  C07K15/04 ,  C12N15/30 ,  C12N15/67

CPC classification number: C07K14/455 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  C12N2830/002 ,  C12N2830/15 ,  Y10S530/822

Abstract: A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.

Abstract translation: 克隆的基因或其片段编码与针对禽类球虫抗原蛋白的单克隆或多价抗体结合的抗原蛋白。

公开(公告)号：US5597571A

公开(公告)日：1997-01-28

申请号：US484387

申请日：1995-06-07

Applicant: James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

Inventor： James W. Jacobson ,  Robert L. Strausberg ,  Susan D. Wilson ,  Sharon H. Pope ,  Susan L. Strausberg ,  Michael D. Ruff ,  Patricia C. Augustine ,  Harry D. Danforth

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N15/30 ,  C12N15/70 ,  C12N15/81 ,  C12N15/86 ,  C12N15/863 ,  A61K39/012

CPC classification number: C12N15/70 ,  C07K14/455 ,  C07K16/20 ,  C12N15/81 ,  C12N15/86 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2795/10043 ,  Y10S530/822

Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

Abstract translation: 本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。 本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

公开(公告)号：US5541231A

公开(公告)日：1996-07-30

申请号：US296252

申请日：1994-08-25

Applicant: Michael D. Ruff ,  Sanvasi R. Kalidindi ,  Joel E. Sutton, Jr.

Inventor： Michael D. Ruff ,  Sanvasi R. Kalidindi ,  Joel E. Sutton, Jr.

IPC: A61K9/20 ,  A61K9/48 ,  A61K31/135 ,  A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22

CPC classification number: A61K31/135 ,  A61K31/137 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/22 ,  A61K9/2013 ,  A61K9/4858

Abstract: This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.

Abstract translation: 本申请公开了一种抑制固体药物制剂中抗抑郁药物安非他酮降解的方法，使药物制剂在一年后维持其初始安非他酮效力的至少80％。

公开(公告)号：US5358970A

公开(公告)日：1994-10-25

申请号：US105437

申请日：1993-08-12

Applicant: Michael D. Ruff ,  Sanyasi R. Kalidindi ,  Joel E. Sutton, Jr.

Inventor： Michael D. Ruff ,  Sanyasi R. Kalidindi ,  Joel E. Sutton, Jr.

IPC: A61K9/20 ,  A61K9/48 ,  A61K31/135 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22

CPC classification number: A61K9/2013 ,  A61K31/135 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/22 ,  A61K9/4858

Abstract: This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.

Abstract translation: 本申请公开了一种抑制固体药物制剂中抗抑郁药物安非他酮降解的方法，使药物制剂在一年后维持其初始安非他酮效力的至少80％。

公开(公告)号：US5122471A

公开(公告)日：1992-06-16

申请号：US308219

申请日：1989-02-09

Applicant: Mark C. Jenkins ,  Hyun S. Lillehoj ,  John B. Dame ,  Harry D. Danforth ,  Michael D. Ruff

Inventor： Mark C. Jenkins ,  Hyun S. Lillehoj ,  John B. Dame ,  Harry D. Danforth ,  Michael D. Ruff

IPC: A61K39/00 ,  C07K14/455 ,  C07K16/20 ,  C12N1/21

CPC classification number: C07K14/455 ,  C07K16/20 ,  A61K39/00

Abstract: Disclosed are DnA sequences which code for antigenic proteins, methods for identifying such DNA sequences, and antigens coded for by such DNA sequences.The first step of the method is to provide a multiplicity of DNA sequences. These sequences are then inserted into DNA expression vectors to form recombinant expression vectors. The expression vectors are inserted into suitable hosts to form transformants which express the DNA sequences. The transformants are then contacted with antibodies directed against Eimeria antigens to identify transformants containing DNA sequences which code for Eimeria antigens. These antigens are then produced from the DNA sequences identified as coding for the antigens. The antigens so produced are contacted with white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein, to thereby identify DNA sequences which code for antigens that induce a cell-mediated immune response to avian coccidiosis.The DNA sequences of the present invention comprise cloned genes or fragments thereof that code on expression for an antigenic protein that activates white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein.

Abstract translation: 公开了编码抗原蛋白质的DnA序列，鉴定此类DNA序列的方法和由该DNA序列编码的抗原。 该方法的第一步是提供多个DNA序列。 然后将这些序列插入DNA表达载体中以形成重组表达载体。 将表达载体插入合适的宿主中以形成表达DNA序列的转化体。 然后将转化体与针对艾美球虫抗原的抗体接触，以鉴定含有编码艾美球虫抗原的DNA序列的转化体。 然后从鉴定为编码抗原的DNA序列产生这些抗原。 这样产生的抗原与影响细胞介导的免疫应答的白细胞接触，白血球对抗原性艾美球虫蛋白致敏，从而鉴定编码诱导细胞介导的免疫应答的抗原的DNA序列 球虫病 本发明的DNA序列包含编​​码激活影响细胞介导的免疫应答的白细胞的抗原性蛋白质的表达的克隆基因或其片段，所述白细胞对抗原性艾美球虫蛋白致敏。