公开(公告)号：US07223420B2

公开(公告)日：2007-05-29

申请号：US10689221

申请日：2003-10-20

申请人： Georg Berger ,  Heidi Marx ,  Christian Jäger ,  Jutta Pauli

发明人： Georg Berger ,  Heidi Marx ,  Christian Jäger ,  Jutta Pauli

IPC分类号： A61L24/00 ,  A61K9/14 ,  A61K33/42 ,  A61K33/08 ,  A61K33/00 ,  A01N59/26 ,  A01N59/06 ,  A01N59/00

CPC分类号： A61L24/001 ,  A61L27/56 ,  A61L2430/02

摘要： The present invention relates to a powder mixture for resorbable calcium phosphate biocements, which mixture consists of 40–99% by volume of powder having a particle size of 0.1–10 μm, 1–20% by volume of powder having a particle size of 10–43 μm and 0–59% by volume of powder having a particle size of 43–315 μm, which powder is obtained by grinding the spontaneously crystallizing melts of a material comprising crystalline and X-ray amorphous phases, which material a) according to 31P-NMR measurements, contains Q0-groups of orthophosphate and Q1-groups of diphosphate, the orthophosphates or Q0-groups making up 65 to 99.9% by weight relative to the total phosphorus content of the powder mixture and the diphosphates or Q1-groups making up 0.1 to 35% by weight relative to the total phosphorus content of the powder mixture, and b) according to X-ray diffractometric measurements and relative to the total weight of the powder mixture, contains 35 to 99.9% by weight of a main crystal phase consisting of various Ca-orthophosphates and 0.1 to 20% by weight of a secondary crystal phase consisting of various Ca-diphosphates and chain phosphates, and c) besides the main crystal phase, contains an X-ray amorphous phase which in total makes up 0.1 to 65% by weight relative to the total weight of the powder mixture.

摘要翻译： 本发明涉及可再吸收的磷酸钙生物聚合物的粉末混合物，该混合物由40-99体积％的粒径为0.1-10μm的粉末，1-20体积％的粒径为10的粉末组成 -43μm和0-59体积％的粉末，其粒径为43-315μm，粉末通过研磨包含结晶和X射线非晶相的材料的自发结晶熔体获得，该材料a）根据 P-NMR测量包含正磷酸盐，正磷酸盐或正好磷酸盐的正二磷酸盐和Q 1 - 亚基的Q 0 - 相对于粉末混合物的总磷含量为65至99.9重量％，相对于该粉末混合物的二磷酸盐或Q 1个亚组为0.1至35重量％ 粉末混合物的总磷含量，和b）根据X射线衍射测量和相对于粉末混合物的总重量，c 包含35〜99.9重量％的由各种正磷酸钙组成的主晶相和0.1〜20重量％的由各种Ca-二磷酸酯和链磷酸酯组成的二次相晶相，以及c）除了主晶相外，还含有 X射线非晶相，相对于粉末混合物的总重量，其总重量为0.1〜65重量％。