公开(公告)号：US4960694A

公开(公告)日：1990-10-02

申请号：US71799

申请日：1987-07-09

申请人： Klaus Eckardt ,  Gottfried Toepfer ,  Andreas Seifert ,  Manfred Schulze ,  Udo Funke ,  Marlena Stepanauskas, deceased ,  by Leonas-Vitas Stepanauskas, legal representative ,  Daina Stepanauskas, legal representative ,  Heinz Thrum, deceased ,  by Margot Thrum, legal representative ,  by Matthias Thrum, legal representative ,  by Michael Thrum, legal representative

发明人： Klaus Eckardt ,  Gottfried Toepfer ,  Andreas Seifert ,  Manfred Schulze ,  Udo Funke ,  Marlena Stepanauskas, deceased ,  by Leonas-Vitas Stepanauskas, legal representative ,  Daina Stepanauskas, legal representative ,  Heinz Thrum, deceased ,  by Margot Thrum, legal representative ,  by Matthias Thrum, legal representative ,  by Michael Thrum, legal representative

IPC分类号： G01N33/86

CPC分类号： G01N33/86 ,  G01N2333/75

摘要： A test reagent for detecting fibrin monomers in blood, comprises an antibiotic of a pyrrole amidine series as a precipitant, introduced in a buffer solution. A method of detecting fibrin monomers in blood, comprises the steps of mixing venous blood with an anticoagulant, centrifuging the mixture of the venous blood with the anticoagulant, removing a citrate plasma, using an antibiotic of a pyrrole amidine series as a precipitant, and evaluating a precipitation reaction which takes place thereby.

摘要翻译： 用于检测血液中纤维蛋白单体的测试试剂包括作为沉淀剂的吡咯脒系列的抗生素，引入缓冲溶液中。 一种检测血液中纤维蛋白单体的方法，包括以静脉血与抗凝血剂混合的方法，使用吡咯脒系列抗生素作为沉淀剂，将静脉血与抗凝血剂的混合物离心，除去柠檬酸血浆，并评价 由此发生沉淀反应。

公开(公告)号：US4861715A

公开(公告)日：1989-08-29

申请号：US572928

申请日：1984-01-20

申请人： Friedrich Bergter ,  Harald Bocker ,  Ernst-Joachim Bormann ,  Wolfgang Forberg ,  Heinz Fricke ,  Udo Grafe ,  Hans-Helmut Grosse ,  Ingeborg Heller ,  Matthias Hilliger ,  Wolf Junne ,  Hellmut Linde ,  Michael Menner ,  Klaus-Dieter Menzel ,  Peter-Jurger Muller ,  Gunter Plonka ,  Hans D. Pohl ,  Jorg Schneider ,  Heinz Thrum

发明人： Friedrich Bergter ,  Harald Bocker ,  Ernst-Joachim Bormann ,  Wolfgang Forberg ,  Heinz Fricke ,  Udo Grafe ,  Hans-Helmut Grosse ,  Ingeborg Heller ,  Matthias Hilliger ,  Wolf Junne ,  Hellmut Linde ,  Michael Menner ,  Klaus-Dieter Menzel ,  Peter-Jurger Muller ,  Gunter Plonka ,  Hans D. Pohl ,  Jorg Schneider ,  Heinz Thrum

IPC分类号： A61K35/74 ,  C12P1/06

CPC分类号： C12P1/06

摘要： A process is disclosed for the fermentative production of the ergotropically effective antibiotic nourseothricin, with which, using different carbohydrate sources and suitable inorganic and organic nitrogen sources as well as different mineral salts, with or without addition of stock substances of the respiratory chain or the intracellular amino acid transport, and through influencing the phosphate substance exchange and avoidance of further limitations with regulated acidity conditions, high concentrations of this antibiotic are cultivated in the culture solution. The recovery of the active substance in the culture solution follows either by chromatographic techniques in the form of salts or through addition of a physiologically compatible adsorbent as mycelium-containing nourseothricin-adsorbate, which preferably can be added to the dosaging of mixed feed agents.

摘要翻译： 公开了一种用于发挥生产有效的抗生素药物的方法，使用不同的碳水化合物来源和合适的无机和有机氮源以及不同的矿物盐，伴有或不添加呼吸链或细胞内的物质 氨基酸转运，通过影响磷酸盐物质的交换，避免受规定酸度条件的进一步限制，培养液中培养出高浓度的抗生素。 培养液中的活性物质的回收率可以通过盐形式的色谱技术或通过添加生理上相容的吸附剂作为含菌丝体的次氯酸盐吸附物，其优选可加入混合饲料的剂量。