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公开(公告)号：US07816376B2
公开(公告)日：2010-10-19
申请号：US10507581
申请日：2003-03-05
IPC分类号： A61K31/445 , A61K31/423 , C07D417/02 , C07D413/02
CPC分类号： C07D263/58 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of the formula (I) and pharmaceutically usable derivatives, salts, solvates and stereoisomers and mixtures thereof, in which X, Y, Z, R1, R3, R4, R8, p, k, E, G, Z and Q are as defined in claim 1, which are employed as excitatory amino acid antagonists for combating neurodegenerative diseases, including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's, Parkinson's or Huntington's disease, cerebral ischaemia, infarction or psychoses.
摘要翻译： 本发明涉及式（I）化合物及其药学上可用的衍生物，盐，溶剂化物和立体异构体及其混合物，其中X，Y，Z，R1，R3，R4，R8，p，k，E，G，Z 和Q如权利要求1所定义，其用作用于对抗神经变性疾病的兴奋性氨基酸拮抗剂，包括脑血管疾病，癫痫，精神分裂症，阿尔茨海默病，帕金森病或亨廷顿病，脑缺血，梗塞或精神病。
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公开(公告)号：US20050124627A1
公开(公告)日：2005-06-09
申请号：US10507581
申请日：2003-03-05
IPC分类号： A61K31/454 , A61K31/497 , A61P9/10 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/36 , A61P43/00 , C07D263/58 , C07D413/12 , C07D413/14 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D417/02
CPC分类号： C07D263/58 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of the formula (I) and pharmaceutically usable derivatives, salts, solvates and stereoisomers and mixtures thereof, in which X, Y, Z, R1, R3, R4, R8, p, k, E, G, Z and Q are as defined in claim 1, which are employed as excitatory amino acid antagonists for combating neurodegenerative diseases, including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's, Parkinson's or Huntington's disease, cerebral ischaemia, infarction or psychoses.
摘要翻译： 本发明涉及式（I）化合物及其药学上可用的衍生物，盐，溶剂化物和立体异构体及其混合物，其中X，Y，Z，R 1，R 3， R 4，R 4，R 8，p，k，E，G，Z和Q如权利要求1中所定义，其用作兴奋性氨基酸拮抗剂 抗击神经变性疾病，包括脑血管疾病，癫痫，精神分裂症，阿尔茨海默病，帕金森病或亨廷顿病，脑缺血，梗死或精神病。
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公开(公告)号：US06333339B1
公开(公告)日：2001-12-25
申请号：US09445587
申请日：2000-04-17
申请人： Henning Boettcher , Helmut Pruecher , Hartmut Greiner , Christoph Seyfried , Andrew Barber , Joseph Maria Martinez
发明人： Henning Boettcher , Helmut Pruecher , Hartmut Greiner , Christoph Seyfried , Andrew Barber , Joseph Maria Martinez
IPC分类号： A61K31445
CPC分类号： C07D401/06
摘要： The invention relates to piperidine derivatives of the formula I in which R1, R2, m and k have the meanings indicated in claim 1, and their salts, novel intermediates and processes for the preparation of the compounds according to the invention. The compounds of the formula I are potent a receptor ligands and show 5-HT reuptake-inhibiting actions and can be used for the production of medicaments, for example for the treatment of disorders of the central nervous system, of strokes, brain or bone marrow traumata or of ischaemic states.
摘要翻译： 本发明涉及式Iin的哌啶衍生物，其中R1，R2，m和k具有权利要求1所示的含义，以及它们的盐，新的中间体和制备本发明化合物的方法。 我是有效的受体配体并显示出5-HT再摄取抑制作用，可以用于制备药物，例如用于治疗中枢神经系统疾病，脑卒中，脑或骨髓创伤或缺血状态 。
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