-
公开(公告)号：US11878028B1
公开(公告)日：2024-01-23
申请号：US18199402
申请日：2023-05-19
发明人： Pan Li , Limin Jia , Zhiyong Qin , Zhaoyang Wang
IPC分类号： A61K31/7068 , A61P35/00 , A61K31/506
CPC分类号： A61K31/7068 , A61K31/506 , A61P35/00
摘要： The present invention discloses a pharmaceutical composition comprising azvudine and an EGFR/TKI inhibitor. The pharmaceutical composition of the present invention shows a good synergistic effect in antitumor, and can delay the generation of drug resistance and improve the therapeutic effect and safety, thereby achieving the goal of prolonging the survival of patients.
-
公开(公告)号：US20230151048A1
公开(公告)日：2023-05-18
申请号：US17604451
申请日：2019-03-21
发明人： Junbiao CHANG , Jinfa DU , Kaikai ZHU , Kai WANG , Jianyong LI , Chunxia ZHANG
IPC分类号： C07H19/16 , A61P31/18 , A61K31/7076 , A61K31/7068 , C07H19/06 , A61K31/683 , A61K31/505 , A61K31/5383 , A61K31/553 , A61K38/16 , A61K31/675
CPC分类号： C07H19/16 , A61K31/505 , A61K31/553 , A61K31/675 , A61K31/683 , A61K31/5383 , A61K31/7068 , A61K31/7076 , A61K38/162 , A61P31/18 , C07H19/06 , C07B2200/13
摘要： The present invention discloses a crystal form, a preparation method and an application of a 4′-substituted nucleoside compound I having the following structure, including salts, prodrugs, and compositions thereof. Animal pharmacokinetic studies demonstrated that the effective drug concentrations of Compound Ia and Compound Ig in HIV target cells, peripheral blood mononuclear cells (PBMC), were effective in inhibiting HIV replication after 7 and 5 days, respectively. Therefore, Compound I can be used as a long-acting drug for preventing and treating AIDS. R is selected from ethynyl, azide, and cyano groups, X is selected from hydrogen and fluorine, and B is selected from B1 and B2.
-
公开(公告)号：US20220024897A1
公开(公告)日：2022-01-27
申请号：US17497994
申请日：2021-10-11
发明人： Junbiao CHANG , Jinfa DU , Kaikai ZHU , Kai WANG , Jianyong LI , Chunxia ZHANG , Dongxu YI
IPC分类号： C07D403/04
摘要： A 2-(2,4,5-substituted phenylamino) pyrimidine derivative, having the following chemical formula I:
-
公开(公告)号：US20190330230A1
公开(公告)日：2019-10-31
申请号：US16503656
申请日：2019-07-05
发明人： Junbiao CHANG , Jinfa DU
IPC分类号： C07D495/04 , A61P35/00
摘要： The disclosure relates to a thienopyrimidinone derivative, or a pharmaceutically acceptable prodrug, salt, and solvate thereof. The derivative has the formula (I), where R represents hydrogen (H) or deuterium (D); R1 and R2 independently, at each occurrence, represent H, D, F, Cl, I, cyano group (CN), or N3, and when R represents H, R1 and R2 do not synchronously represent H; R3, R4 and R5 independently, at each occurrence, represent an alkyl group, a cycloalkyl group, a heterocyclic group, an aromatic ring group, or a heteroaryl ring group, which are substituted or unsubstituted.
-
公开(公告)号：US20240299383A1
公开(公告)日：2024-09-12
申请号：US18205628
申请日：2023-06-05
发明人： Pan LI , Limin JIA , Zhiyong QIN , Zhaoyang WANG
IPC分类号： A61K31/506 , A61P37/04 , C07K16/28
CPC分类号： A61K31/506 , A61P37/04 , C07K16/2818 , C07K16/2827
摘要： The present invention discloses the inhibitory effect of azvudine as an immunomodulator on mice bearing CT-26 tumor. It is found that azvudine has no significant anti-tumor effect on immunodeficient B-NDG mice bearing CT-26 tumor, yet has an antitumor effect on BALB/c mice with normal immunity bearing CT-26 tumor model. The present invention further studies the combined effect of azvudine and PD-1 antibody, and finds that compared with a single drug, the combined administration has a synergistic anti-tumor effect.
-
公开(公告)号：US20240293438A1
公开(公告)日：2024-09-05
申请号：US18200000
申请日：2023-05-22
发明人： Pan LI , Limin JIA , Zhiyong QIN , Zhaoyang WANG
IPC分类号： A61K31/7068 , A61K31/337 , A61K31/655 , A61K31/675 , A61K39/395 , A61P35/00 , A61P35/02
CPC分类号： A61K31/7068 , A61K31/337 , A61K31/655 , A61K31/675 , A61K39/3955 , A61P35/00 , A61P35/02
摘要： The present invention discloses a pharmaceutical composition comprising azvudine and a chemotherapeutic agent. The pharmaceutical composition of the present invention shows a good synergistic effect in antitumor, and can reduce the dosage of chemotherapeutic agent, and improve the therapeutic effect and safety, thereby achieving the goal of prolonging the survival of patients.
-
公开(公告)号：US20230277576A1
公开(公告)日：2023-09-07
申请号：US17905142
申请日：2021-02-20
发明人： Junbiao CHANG , Jinfa DU , Jiandong JIANG , Yuhuan LI
IPC分类号： A61K31/7068 , A61P31/14
CPC分类号： A61K31/7068 , A61P31/14
摘要： The present invention relates to a method for preventing or treating a coronavirus infectious disease, comprising administering to a patient in need thereof a therapeutically or prophylactically effective amount of a compound represented by formula (I) or pharmaceutically acceptable salts thereof. The compound represented by formula (I) is used for treating patients with novel coronavirus pneumonia, and shows obvious advantages in all of the clearance rate by viral nucleic acid test, the course of clearance, and the cure and discharge time.
-
公开(公告)号：US11578049B2
公开(公告)日：2023-02-14
申请号：US17026339
申请日：2020-09-21
发明人： Junbiao Chang , Jinfa Du , Kaikai Zhu , Kai Wang
IPC分类号： C07D307/83 , A61P25/00 , C07C69/78 , C07D307/88 , C07C67/307 , C07C67/343
摘要： A compound represented by formula I or II. X represents a mono substituent on a benzene ring, and is selected from —H, —I, —Br, —Cl, —F, —CN, an amino, and a derivative thereof; R1 is a C2-10 alkyl, C2-10 alkyl substituted by cyclopropane or fluorine, except n-butyl; and M is an amine ion or metal ion.
-
公开(公告)号：US20220002333A1
公开(公告)日：2022-01-06
申请号：US17475377
申请日：2021-09-15
发明人： Junbiao CHANG , Jinfa DU , Dongxu YI
摘要： A crystalline form A of a compound I is a monoclinic system and a space group thereof is p21.
-
公开(公告)号：US20210002244A1
公开(公告)日：2021-01-07
申请号：US17026339
申请日：2020-09-21
发明人： Junbiao CHANG , Jinfa DU , Kaikai ZHU , Kai WANG
IPC分类号： C07D307/83 , C07C69/78 , A61P25/00 , C07C67/307 , C07C67/343
摘要： A compound represented by formula I or II. X represents a mono substituent on a benzene ring, and is selected from —H, —I, —Br, —Cl, —F, —CN, an amino, and a derivative thereof; R1 is a C2-10 alkyl, C2-10 alkyl substituted by cyclopropane or fluorine, except n-butyl; and M is an amine ion or metal ion.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.015 秒)
