公开(公告)号：US11578049B2

公开(公告)日：2023-02-14

申请号：US17026339

申请日：2020-09-21

申请人： Henan Genuine Biotech Co., Ltd.

发明人： Junbiao Chang ,  Jinfa Du ,  Kaikai Zhu ,  Kai Wang

IPC分类号： C07D307/83 ,  A61P25/00 ,  C07C69/78 ,  C07D307/88 ,  C07C67/307 ,  C07C67/343

摘要： A compound represented by formula I or II. X represents a mono substituent on a benzene ring, and is selected from —H, —I, —Br, —Cl, —F, —CN, an amino, and a derivative thereof; R1 is a C2-10 alkyl, C2-10 alkyl substituted by cyclopropane or fluorine, except n-butyl; and M is an amine ion or metal ion.

公开(公告)号：US10919908B2

公开(公告)日：2021-02-16

申请号：US16503656

申请日：2019-07-05

申请人： Henan Genuine Biotech Co., Ltd.

发明人： Junbiao Chang ,  Jinfa Du

IPC分类号： A61P35/00 ,  C07D495/04 ,  A61K45/06

摘要： The disclosure relates to a thienopyrimidinone derivative, or a pharmaceutically acceptable prodrug, salt, and solvate thereof. The derivative has the formula (I), where R represents hydrogen (H) or deuterium (D); R1 and R2 independently, at each occurrence, represent H, D, F, Cl, I, cyano group (CN), or N3, and when R represents H, R1 and R2 do not synchronously represent H; R3, R4 and R5 independently, at each occurrence, represent an alkyl group, a cycloalkyl group, a heterocyclic group, an aromatic ring group, or a heteroaryl ring group, which are substituted or unsubstituted.