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1.发明授权Process for converting penicillin sulfoxides to the corresponding 3-desacetoxycephalosporins 失效将青霉素亚砜转化为相应的3-脱乙酰氧基头孢菌素的方法
公开(公告)号：US4051133A
公开(公告)日：1977-09-27
申请号：US646321
申请日：1976-01-02
IPC分类号： A61K20060101 , C07C20060101 , C07D20060101 , C07D501/10 , C07D501/22
CPC分类号： C07D501/10
摘要： Conversion of penicillin sulfoxides to the corresponding 3-desacetoxycelphalosporins are carried out in high yield by heating, e.g. 80.degree.-130.degree. C, a solvent solution of the penicillin in the presence of a complex formed by a phosphite or phosphine amide with the salt of a strong acid and a nitrogenous base, e.g. alpha-picoline hydrobromide.One preferred amide is 2-piperidino-1,3,2-dioxaphospolane.
摘要翻译： 通过加热将青霉素亚砜转化成相应的3-脱乙酰氧基封端孢子，以高产率进行。 80°-130℃，在由亚磷酸盐或膦酰胺与强酸和含氮碱的盐形成的络合物存在下，青霉素的溶剂溶液。 α-甲基吡啶氢溴酸盐。
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公开(公告)号：US3994883A
公开(公告)日：1976-11-30
申请号：US427363
申请日：1973-12-21
IPC分类号： C07D499/00 , C07D499/12 , C07D499/42 , C07D501/06 , C07D501/18 , C07F9/6561 , C07D499/02
CPC分类号： C07D499/00 , C07F9/65611 , C07F9/65613
摘要： Novel penicillin and cephalosporin intermediates for the synthesis of 6-APA or 7-aminocephem compounds involving formation of a 6 or 7 phosphite amido compound and the conversion of such compound to a desired 6-APA or 7-aminocephem compound.
摘要翻译： 用于合成涉及形成6或7亚磷酸酰胺化合物的6-APA或7-氨基头孢烯化合物的新型青霉素和头孢菌素中间体以及将该化合物转化为所需的6-APA或7-氨基头孢烯化合物。
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3.发明授权Process for the preparation of phosphorus derivatives of secondary ammonium salts of penam and cephem compounds 失效制备PENAM和CEPHEM化合物的次级钠盐的磷酸盐衍生物的方法
公开(公告)号：US4082745A
公开(公告)日：1978-04-04
申请号：US669048
申请日：1976-03-22
IPC分类号： C07D499/00 , C07D499/12 , C07D499/42 , C07D501/06 , C07F9/6561 , C07D499/14 , C07D501/04
CPC分类号： C07D499/00 , C07F9/65611 , C07F9/65613
摘要： An improvement in the conversion of penam and cephem compounds to secondary ammonium salts of phosphite amides thereof by reacting as follows: ##STR1## wherein --R, is the non-reacting balance of the penam or cephem compound and ##STR2## ARE NON-REACTING SUBSTITUENTS. Catalytic amounts of H--N
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