公开(公告)号：US08563626B2

公开(公告)日：2013-10-22

申请号：US12602613

申请日：2007-06-01

申请人： Roberto Olayo Gonzalez ,  Juan Morales Corona ,  Rodrigo Lozano Mondragon ,  Ana Laura Alvarez Mejia ,  Juan Carlos Axayacatl Morales Guadarrama ,  Luis Camilo Rios Castañeda ,  Maria de los Angeles Araceli Diaz Ruiz ,  Guillermo Jesús Cruz Cruz ,  María Guadalupe Olayo González ,  Hermelinda Salgado Ceballos

发明人： Roberto Olayo Gonzalez ,  Juan Morales Corona ,  Rodrigo Lozano Mondragon ,  Ana Laura Alvarez Mejia ,  Juan Carlos Axayacatl Morales Guadarrama ,  Luis Camilo Rios Castañeda ,  Maria de los Angeles Araceli Diaz Ruiz ,  Guillermo Jesús Cruz Cruz ,  María Guadalupe Olayo González ,  Hermelinda Salgado Ceballos

IPC分类号： A61F2/02

CPC分类号： C08G61/124 ,  A61L27/18 ,  A61L27/26 ,  A61L2430/32 ,  C08G73/0611 ,  C08G2261/3221 ,  C08L71/02

摘要： The purpose of the present invention is to demonstrate that semiconducting and non-biodegradable implants made with polypyrrole and polyethylenglycol copolymers and iodine-doped and plasma-synthesized pyrrole polymers, have a neuroprotector effect and induce the reconnection of the spinal cord after an injury; this effect was proved in a model involving a complete section of the spinal cord in rats; the results o the functional evaluation demonstrated 5 times greater recovery in animals implanted with the polypyrrole-polyethylenglycol copolymer compared with the control group which only underwent a complete section of the spinal cord; in addition, the functional recovery of the group with iodine-doped polypyrrole was ten times greater compared to the control group; in the histological study various inflammatory and immune cells were identified at the injury site in the three experimental groups with and without implants and the integration of the polymers in the nervous tissue of the spinal cord was also observed; finally, no respiratory, renal or skin infections, adverse effects or rejection of the biomaterials were found in any of the animals.

摘要翻译： 本发明的目的是证明用聚吡咯和聚乙二醇共聚物和碘掺杂和等离子体合成的吡咯聚合物制成的半导体和不可生物降解的植入物具有神经保护作用并且在损伤后引起脊髓重新连接; 在大鼠脊髓完整部分的模型中证明了这一作用; 功能评估结果显示，与仅经历脊髓完整部分的对照组相比，植入聚吡咯 - 聚乙二醇共聚物的动物恢复5倍。 此外，与掺杂聚吡咯的组相比，对照组的功能恢复是十倍以上。 在组织学研究中，在有和没有植入物的三个实验组中，在损伤部位鉴定出各种炎症和免疫细胞，并观察到聚合物在脊髓神经组织中的整合; 最后，在任何动物中都没有发现呼吸系统，肾脏或皮肤感染，生物材料的不良反应或排斥。

公开(公告)号：US20100234488A1

公开(公告)日：2010-09-16

申请号：US12602613

申请日：2007-06-01

申请人： Roberto Olayo Gonzalez ,  Juan Morales Corona ,  Rodrigo Lozano Mondragon ,  Ana Laura Alvarez Mejia ,  Juan Carlos Axayacatl Morales Guadarrama ,  Luis Camilo Rios Castañeda ,  María de los Angeles Araceli Diaz Ruiz ,  Guillermo Jesús Cruz Cruz ,  María Guadalupe Olayo González ,  Hermelinda Salgado Ceballos

发明人： Roberto Olayo Gonzalez ,  Juan Morales Corona ,  Rodrigo Lozano Mondragon ,  Ana Laura Alvarez Mejia ,  Juan Carlos Axayacatl Morales Guadarrama ,  Luis Camilo Rios Castañeda ,  María de los Angeles Araceli Diaz Ruiz ,  Guillermo Jesús Cruz Cruz ,  María Guadalupe Olayo González ,  Hermelinda Salgado Ceballos

IPC分类号： A61L27/14 ,  C08G73/00

CPC分类号： C08G61/124 ,  A61L27/18 ,  A61L27/26 ,  A61L2430/32 ,  C08G73/0611 ,  C08G2261/3221 ,  C08L71/02

摘要： The purpose of the present invention is to demonstrate that semiconducting and non-biodegradable implants made with polypyrrole and polyethylenglycol copolymers and iodine-doped and plasma-synthesised pyrrole polymers, have a neuroprotector effect and induce the reconnection of the spinal cord after an injury; this effect was proved in a model involving a complete section of the spinal cord in rats; the results o the functional evaluation demonstrated 5 times greater recovery in animals implanted with the polypyrrole-polyethylenglycol copolymer compared with the control group which only underwent a complete section of the spinal cord; in addition, the functional recovery of the group with iodine-doped polypyrrole was ten times greater compared to the control group; in the histological study various inflammatory and immune cells were identified at the injury site in the three experimental groups with and without implants and the integration of the polymers in the nervous tissue of the spinal cord was also observed; finally, no respiratory, renal or skin infections, adverse effects or rejection of the biomaterials were found in any of the animals.

摘要翻译： 本发明的目的是证明用聚吡咯和聚乙二醇共聚物和碘掺杂和等离子体合成的吡咯聚合物制成的半导体和不可生物降解的植入物具有神经保护作用并且在损伤后引起脊髓重新连接; 在大鼠脊髓完整部分的模型中证明了这一作用; 功能评估结果显示，与仅经历脊髓完整部分的对照组相比，植入聚吡咯 - 聚乙二醇共聚物的动物恢复5倍。 此外，与掺杂聚吡咯的组相比，对照组的功能恢复是十倍以上。 在组织学研究中，在有和没有植入物的三个实验组中，在损伤部位鉴定出各种炎症和免疫细胞，并观察到聚合物在脊髓神经组织中的整合; 最后，在任何动物中都没有发现呼吸系统，肾脏或皮肤感染，生物材料的不良反应或排斥。