公开(公告)号：US20110123627A1

公开(公告)日：2011-05-26

申请号：US12999547

申请日：2009-04-15

申请人： Larry Yun Fang ,  David Harris ,  Gopal Krishna ,  Allen E. Moton, JR. ,  Russell C. Prestipino ,  Marc Steinman ,  Jiansheng Wan ,  Hetty Anne Waskin

发明人： Larry Yun Fang ,  David Harris ,  Gopal Krishna ,  Allen E. Moton, JR. ,  Russell C. Prestipino ,  Marc Steinman ,  Jiansheng Wan ,  Hetty Anne Waskin

IPC分类号： A61K31/496 ,  A61K9/14 ,  A61P31/10

CPC分类号： A61K47/38 ,  A61K9/14 ,  A61K9/1652 ,  A61K31/496

摘要： The present application provides novel compositions comprising posaconazole and a polymer wherein the composition has a glass transition temperature (Tg) of less than about 1100 C. The application also describes compositions comprising posaconazole and a polymer having a bulk density of greater than about 0.4 mg/mL. The application also describes compositions comprising posaconazole and a polymer which provide an exposure (AUCtf) of at least about 10,000 ng·hr/mL when administered to a patient in a fasted state. The application also describes a novel process for preparing these compositions. The preff erred polymer is HPMCAS. Preferably the composition is an extruded material.

摘要翻译： 本申请提供了包含泊沙康唑和聚合物的新型组合物，其中组合物的玻璃化转变温度（Tg）小于约1100℃。本申请还描述了包含泊沙康唑和堆积密度大于约0.4mg / mL。 本申请还描述了当以禁食状态给予患者时，包含泊沙康唑和提供至少约10,000ng·hr / mL的暴露（AUCtf）的聚合物的组合物。 本申请还描述了一种制备这些组合物的新方法。 优先聚合物是HPMCAS。 优选地，组合物是挤出材料。