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公开(公告)号:US20140037710A1
公开(公告)日:2014-02-06
申请号:US14112709
申请日:2012-04-12
申请人: Eiji Hashimoto , Isao Hagiwara , Yukihisa Naka , Hideharu Chono
发明人: Eiji Hashimoto , Isao Hagiwara , Yukihisa Naka , Hideharu Chono
IPC分类号: A61K9/70
CPC分类号: A61K9/7061 , A61K9/7053 , A61K31/216 , A61K31/4353 , A61K31/5513 , A61K47/12
摘要: A method for producing a patch including a support layer and an adhesive layer, comprising the step of forming the adhesive layer with use of an adhesive layer composition obtained by mixing an alkali metal diacetate, a drug, and a nonaqueous adhesive base such that the molar ratio between the drug and the alkali metal diacetate (the number of moles of the drug:the number of moles of the alkali metal diacetate) is from 1:0.5 to 1:15.
摘要翻译: 一种制造包括支撑层和粘合剂层的贴剂的方法,包括使用通过混合碱金属二乙酸酯,药物和非水性粘合剂基质获得的粘合剂层组合物形成粘合剂层的步骤,使得摩尔 药物与碱金属二乙酸酯的比例(药物的摩尔数:碱金属二乙酸酯的摩尔数)为1:0.5至1:15。
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公开(公告)号:US08420117B2
公开(公告)日:2013-04-16
申请号:US12831190
申请日:2010-07-06
CPC分类号: A61K9/7053 , A61K47/12
摘要: A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.
摘要翻译: 公开了将碱性药物,有机酸和有机酸盐组合为必需成分的外用贴剂。 碱性药物优选为其酸加成盐的形式。 有机酸优选为碳原子数为2〜7的羧酸,更优选为选自乙酸,乳酸,酒石酸,柠檬酸,苹果酸,苯甲酸和水杨酸中的至少一种酸。 有机酸盐优选为羧酸的金属盐,更优选为乙酸钠。
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公开(公告)号:US20070184097A1
公开(公告)日:2007-08-09
申请号:US11725929
申请日:2007-03-20
IPC分类号: A61K31/74
CPC分类号: A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/14 , A61K31/165 , A61K31/167 , A61K31/215 , A61K31/222 , A61K31/415 , A61K31/433 , A61K31/445 , A61K31/4535 , A61K31/55
摘要: Adhesive preparations with improved percutaneous absorption of physiologically active substances, in particular, matrix adhesive preparations containing a base drug salt and an organic acid salt having an mean diameter of from 0.1 to 100 μm are provided.
摘要翻译: 提供具有改善的生理活性物质的经皮吸收的粘合剂制剂,特别是含有基础药物盐和平均直径为0.1至100μm的有机酸盐的基质粘合剂制剂。
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公开(公告)号:US20110027365A1
公开(公告)日:2011-02-03
申请号:US12831190
申请日:2010-07-06
IPC分类号: A61K9/14 , A61P25/20 , A61P25/16 , A61P23/02 , A61P25/06 , A61P29/00 , A61P9/06 , A61P25/04 , A61P1/08 , A61K31/433 , A61K31/24
CPC分类号: A61K9/7053 , A61K47/12
摘要: A patch formulation for external use where a basic drug, an organic acid and an organic acid salt are combined as essential components is disclosed. The basic drug is preferably in the form of its acid addition salt. The organic acid is preferably a carboxylic acid having carbon atoms of 2 to 7, and more preferably at least one acid selected from the group consisting of acetic, lactic, tartaric, citric, malic, benzoic and salicylic acids. The organic acid salt is preferably a metal salt of a carboxylic acid, and more preferably sodium acetate.
摘要翻译: 公开了将碱性药物,有机酸和有机酸盐组合为必需成分的外用贴剂。 碱性药物优选为其酸加成盐的形式。 有机酸优选为碳原子数为2〜7的羧酸,更优选为选自乙酸,乳酸,酒石酸,柠檬酸,苹果酸,苯甲酸和水杨酸中的至少一种酸。 有机酸盐优选为羧酸的金属盐,更优选为乙酸钠。
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5.
公开(公告)号:US6139866A
公开(公告)日:2000-10-31
申请号:US981475
申请日:1998-01-13
IPC分类号: A61K9/70 , A61K31/19 , A61K31/4453 , A61K31/4468 , A61K47/12 , A61L15/22 , A61L15/58 , A61P23/02 , A61P29/00 , A61L9/70 , A61L15/00 , A61L15/16 , A61L31/38
CPC分类号: A61K9/7053 , A61K31/4453 , A61K31/4468 , A61K47/12 , A61K9/7061 , A61K9/7076
摘要: A tape formulation for percutaneous administration containing fentanyl which comprises fentanyl or a salt thereof, a pressure sensitive adhesive and sodium acetate, is disclosed. The salt of fentanyl is preferably fentanyl citrate. The tape formulation of the present invention is little irritation to the skin and excellent in the percutaneous permeation of fentanyl and has a high stability even after the passage of time.
摘要翻译: PCT No.PCT / JP97 / 01595 Sec。 371日期1998年1月13日 102(e)日期1998年1月13日PCT提交1997年5月13日PCT公布。 公开号WO97 / 42952 日本1997年11月20日公开了含有芬太尼或其盐,压敏粘合剂和乙酸钠的经皮给药的胶带制剂。 芬太尼的盐优选为柠檬酸芬太尼。 本发明的胶带配方对皮肤刺激性很小,芬太尼的经皮渗透性优异,即使经过时也具有高稳定性。
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