公开(公告)号：US4952338A

公开(公告)日：1990-08-28

申请号：US907882

申请日：1986-09-16

申请人： Lamar Field ,  Hikmat Mussallam ,  Jeffrey D. Macke ,  Pramod K. Srivastava

发明人： Lamar Field ,  Hikmat Mussallam ,  Jeffrey D. Macke ,  Pramod K. Srivastava

IPC分类号： C07C323/64

CPC分类号： C07C323/64

摘要： Unsymmetrical organic disulfide sulfinate compounds, useful as an antiradiation agents, having the general formula: ##STR1## wherein A is one or of the following polar groups, OH, COOH, SO.sub.3 Na, --C(O)--, or derivatives such as esters and nonamino nitrogen derivatives such as amides or nitriles; k is an integer of one to eight; Y is a straight or substituted aliphatic chain haivng from two to eight carbon atoms which may have one or more S--S groups interposed therebetween; m signifies the number of carbon atoms in an aliphatic chain Y containing 2 to 8 carbon stoms which may have S--S interposed; aliphatic chain Y, substituted with one or more polar groups of the number k is attached to one of the two sulfur atoms shown. The second sulfur atom is attached through an aliphatic chain of 2 to 5 carbon atoms to the sulfinate function SO.sub.2 M wherein R.sup.1 and R.sup.2 may be hydrogen, aryl, cycloalkyl or various polar groups such as OH, COOH, SO.sub.3 Na, --C(O)--, or derivatives such as esters and nonamino derivatives such as amides or nitriles. The system ##STR2## also may comprise an aromatic ring; n may be the integers 2 through 6; M of the sulfinate function is hydrogen, a metallic element selected from group 1 A of the Periodic Table such as Li, Na, or K, or the equivalent R.sub.4 N+; or an organic group such as a straight or substituted aliphatic chain having up to 4 carbon atoms, designed to promote stability. The synthesis of the compounds occurs by subjecting 1,1-dioxides of cyclic disulfidesto the action of a thiolate ion, whereby cleavage is effected between the sulfur and sulfonyl units.

摘要翻译： 可用作抗辐射剂的非对称有机二硫化物亚磺酸盐化合物，具有以下通式：其中A是一个或以下极性基团，OH，COOH，SO 3 Na，-C（O） - 或衍生物，例如酯和 非氨基氮衍生物如酰胺或腈; k是1到8的整数; Y是可以具有两个至八个碳原子的直链或取代的脂族链，它们之间可以具有一个或多个S-S基团; m表示含有可插入S-S的2〜8个碳原子的脂族链Y中的碳原子数; 由数个k的一个或多个极性基团取代的脂族链Y连接到所示的两个硫原子中的一个上。 第二硫原子通过2至5个碳原子的脂族链连接到亚磺酸盐官能团SO 2 M上，其中R 1和R 2可以是氢，芳基，环烷基或各种极性基团，例如OH，COOH，SO 3 N a，-C（O） - ，或衍生物如酯和非氨基衍生物如酰胺或腈。 系统还可以包括芳环; n可以是整数2到6; 亚硫酸盐官能团的M为氢，选自元素周期表的一种元素的金属元素如Li，Na或K，或当量的R4N +; 或有机基团，例如具有至多4个碳原子的直链或取代的脂族链，旨在促进稳定性。 化合物的合成通过使环状二硫化物的1,1-二氧化物进行硫醇盐离子的作用而发生，由此在硫和磺酰基单元之间进行切割。