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    Method to prepare trimethylsulfonium halides
    1.
    发明授权
    Method to prepare trimethylsulfonium halides 失效
    制备三甲基锍卤化物的方法

    公开(公告)号：US5118842A

    公开(公告)日：1992-06-02

    申请号：US615829

    申请日：1990-11-16

    申请人： Peter E. Newallis ,  Jeffrey D. Macke ,  Karl G. Steinbeck ,  Daniel M. Wasleski

    发明人： Peter E. Newallis ,  Jeffrey D. Macke ,  Karl G. Steinbeck ,  Daniel M. Wasleski

    IPC分类号： C07C381/12

    CPC分类号： C07C381/12

    摘要： Trimethylsulfonium halides are made by reacting dimethyl sulfide and a methyl halide in the presence of a solvent mixture which includes water and a water-immiscible organic solvent. The organic water-immiscible solvent is generally present in an amount which is at least 40% but no more than 95% of the total solvent mixture. The reaction is preferably conducted under pressure.

    摘要翻译： 三甲基锍卤化物通过二甲基硫醚和甲基卤化物在包括水和与水不混溶的有机溶剂的溶剂混合物存在下反应制备。 有机水不混溶溶剂的存在量通常为总溶剂混合物的至少40％但不超过95％。 反应优选在压力下进行。

    Unsymmetrical organic disulfide compounds useful as antiradiation agents
    3.
    发明授权
    Unsymmetrical organic disulfide compounds useful as antiradiation agents 失效
    用作抗辐射剂的不对称有机二硫化物

    公开(公告)号：US4943657A

    公开(公告)日：1990-07-24

    申请号：US365891

    申请日：1989-06-14

    申请人： Lamar Field ,  Hikmat A. Musallam ,  Jeffrey D. Macke ,  Pramod K. Srivastava

    发明人： Lamar Field ,  Hikmat A. Musallam ,  Jeffrey D. Macke ,  Pramod K. Srivastava

    IPC分类号： C07C323/64

    CPC分类号： C07C323/64

    摘要： Unsymmetrical organic disulfide sulfinate compounds, useful as an antiradiation agents, having the general formula: ##STR1## wherein A is one or of the following polar groups, OH, COOH, SO.sub.3 Na, --C(O)--, or derivatives such as esters and nonamino nitrogen derivatives such as amides or nitriles; k is an integer of one to eight; Y is a straight or substituted aliphatic chain having from two to eight carbon atoms which may have one or more S--S groups interposed therebetween; m signifies the number of carbon atoms in an aliphatic chain Y containing 2 to 8 carbon atoms which may have S--S interposed; aliphatic chain Y, substituted with one or more polar groups of the number k is attached to one of the two sulfur atoms shown. The second sulfur atom is attached through an aliphatic chain of 2 to 5 carbon atoms to the sulfinate function SO.sub.2 M wherein R.sup.1 and R.sup.2 may be hydrogen, aryl, cycloalkyl or various polar groups such as OH, COOH, SO.sub.3 Na, --C(O)--, or derivatives such as esters and nonamino derivatives such as amides or nitriles. The system ##STR2## also may comprise an aromatic ring; n may be the integers 2 through 6; M of the sulfinate function is hydrogen, a metallic element selected from group 1 A of the Periodic Table such as Li, Na, or K, or the equivalent R.sub.4 N+; or an organic group such as a straight or substituted aliphatic chain having up to 4 carbon atoms, designed to promote stability. The synthesis of the compounds occurs by subjecting 1,1-dioxides of cyclic disulfides to the action of a thiolate ion, whereby cleavage is effected between the sulfur and sulfonyl units.

    摘要翻译： 可用作抗辐射剂的非对称有机二硫化物亚磺酸盐化合物，具有以下通式：其中A是一个或以下极性基团，OH，COOH，SO 3 Na，-C（O） - 或衍生物，例如酯和 非氨基氮衍生物如酰胺或腈; k是1到8的整数; Y是具有2至8个碳原子的直链或取代的脂肪族链，它们之间可以具有一个或多个S-S基团; m表示可插入S-S的含有2〜8个碳原子的脂族链Y中的碳原子数; 由数个k的一个或多个极性基团取代的脂族链Y连接到所示的两个硫原子中的一个上。 第二硫原子通过2至5个碳原子的脂族链连接到亚磺酸盐官能团SO 2 M上，其中R 1和R 2可以是氢，芳基，环烷基或各种极性基团，例如OH，COOH，SO 3 N a，-C（O） - ，或衍生物如酯和非氨基衍生物如酰胺或腈。 系统还可以包括芳环; n可以是整数2到6; 亚硫酸盐官能团的M为氢，选自元素周期表的一种元素的金属元素如Li，Na或K，或当量的R4N +; 或有机基团，例如具有至多4个碳原子的直链或取代的脂族链，旨在促进稳定性。 化合物的合成通过使环状二硫化物的1,1-二氧化物发生硫醇盐离子的作用而发生，从而在硫磺和磺酰基单元之间进行切割。

    Unsymmetrical organic disulfide compounds useful as antiradiation agents
    4.
    发明授权
    Unsymmetrical organic disulfide compounds useful as antiradiation agents 失效
    用作抗辐射剂的不对称有机二硫化物

    公开(公告)号：US4883890A

    公开(公告)日：1989-11-28

    申请号：US228010

    申请日：1988-08-03

    申请人： Lamar Field ,  Hikmat A. Musallam ,  Jeffrey D. Macke ,  Pramod K. Srivastava

    发明人： Lamar Field ,  Hikmat A. Musallam ,  Jeffrey D. Macke ,  Pramod K. Srivastava

    IPC分类号： C07C323/64

    CPC分类号： C07C323/64

    摘要： Unsymmetrical organic disulfide sulfinate compounds, useful as an antiradiation agents, having the general formula: ##STR1## wherein A is one or of the following polar groups, OH, COOH, SO.sub.3 Na, --C(O)--, or derivatives such as esters and nonamino nitrogen derivatives such as amides or nitriles; k is an integer of one to eight; Y is a straight or substituted aliphatic chain having from two to eight carbon atoms which may have one or more S--S groups interposed therebetween; m signifies the number of carbon atoms in an aliphatic chain Y containing 2 to 8 carbon atoms which may have S--S interposed; aliphatic chain Y, substituted with one or more polar groups of the number k is attached to one of the two sulfur atoms shown. The second sulfur atom is attached through an aliphatic chain of 2 to 5 carbon atoms to the sulfinate function SO.sub.2 M wherein R.sup.1 and R.sup.2 may be hydrogen, aryl, cycloalkyl or various polar groups such as OH, COOH, SO.sub.3 Na, --C(O)--, or derivatives such as esters and nonamino derivatives such as amides or nitriles. The system ##STR2## also may comprise an aromatic ring; n may be the integers 2 through 6; M of the sulfinate function is hydrogen, a metallic element selected from group 1 A of the Periodic Table such as Li, Na, or K, or the equivalent R.sub.4 N+; or an organic group such as a straight or substituted aliphatic chain having up to 4 carbon atoms, designed to promote stability. The synthesis of the compounds occurs by subjecting 1,1-dioxides of cyclic disulfides to the action of a thiolate ion, whereby cleavage is effected between the sulfur and sulfonyl units.

    摘要翻译： 可用作抗辐射剂的非对称有机二硫化物亚磺酸盐化合物，具有以下通式：其中A是一个或以下极性基团，OH，COOH，SO 3 Na，-C（O） - 或衍生物，例如酯和 非氨基氮衍生物如酰胺或腈; k是1到8的整数; Y是具有2至8个碳原子的直链或取代的脂肪族链，它们之间可以具有一个或多个S-S基团; m表示可插入S-S的含有2〜8个碳原子的脂族链Y中的碳原子数; 由数个k的一个或多个极性基团取代的脂族链Y连接到所示的两个硫原子中的一个上。 第二硫原子通过2至5个碳原子的脂族链连接到亚磺酸盐官能团SO 2 M上，其中R 1和R 2可以是氢，芳基，环烷基或各种极性基团，例如OH，COOH，SO 3 N a，-C（O） - ，或衍生物如酯和非氨基衍生物如酰胺或腈。 系统还可以包括芳环; n可以是整数2到6; 亚硫酸盐官能团的M为氢，选自元素周期表的一种元素的金属元素如Li，Na或K，或当量的R4N +; 或有机基团，例如具有至多4个碳原子的直链或取代的脂族链，旨在促进稳定性。 化合物的合成通过使环状二硫化物的1,1-二氧化物发生硫醇盐离子的作用而发生，从而在硫磺和磺酰基单元之间进行切割。

    Process for the production of oxiranes
    6.
    发明授权
    Process for the production of oxiranes 失效
    生产环氧乙烷的方法

    公开(公告)号：US5256802A

    公开(公告)日：1993-10-26

    申请号：US504784

    申请日：1990-04-03

    申请人： Jeffrey D. Macke ,  Peter E. Newallis ,  Karl G. Steinbeck

    发明人： Jeffrey D. Macke ,  Peter E. Newallis ,  Karl G. Steinbeck

    IPC分类号： C07D301/02 ,  C07D303/08 ,  C07D301/14

    CPC分类号： C07D303/08 ,  C07D301/02

    摘要： Oxiranes are made from ketones by heating a ketone which is preferably an alkyl ketone to a temperature of from about 60.degree. to about 90.degree. C. (preferably about 80.degree. C.) in the presence of a sulfonium salt, a quaternary ammonium salt and a potassium hydroxide solution which is at least 61% potassium hydroxide. It is preferred that no organic solvent be included in the reaction mixture. The potassium hydroxide is generally included in an amount such that for every mole of ketone, from about 3 to about 4 moles of potassium hydroxide are present. The sulfonium salt is generally used in an amount of at least 1.1 moles for each mole of ketone. The quaternary ammonium salt is generally used in an amount of from about 1 to about 5 mol % based on moles of ketone present.

    摘要翻译： 通过在锍盐，季铵盐和季铵盐存在下将优选烷基酮的酮加热至约60℃至约90℃（优选约80℃）的温度，由环酮衍生得到环烷烃， 至少61％氢氧化钾的氢氧化钾溶液。 优选在反应混合物中不含有机溶剂。 氢氧化钾通常含有的量使得对于每摩尔酮，存在约3至约4摩尔的氢氧化钾。 锍盐的用量通常为每摩尔酮至少1.1摩尔。 季铵盐的使用量通常以所存在的酮的摩尔数计约1至约5mol％。

    Unsymmetrical organic disulfide compounds useful as antiradiation agents
    9.
    发明授权
    Unsymmetrical organic disulfide compounds useful as antiradiation agents 失效
    用作抗辐射剂的不对称有机二硫化物

    公开(公告)号：US4952338A

    公开(公告)日：1990-08-28

    申请号：US907882

    申请日：1986-09-16

    申请人： Lamar Field ,  Hikmat Mussallam ,  Jeffrey D. Macke ,  Pramod K. Srivastava

    发明人： Lamar Field ,  Hikmat Mussallam ,  Jeffrey D. Macke ,  Pramod K. Srivastava

    IPC分类号： C07C323/64

    CPC分类号： C07C323/64

    摘要： Unsymmetrical organic disulfide sulfinate compounds, useful as an antiradiation agents, having the general formula: ##STR1## wherein A is one or of the following polar groups, OH, COOH, SO.sub.3 Na, --C(O)--, or derivatives such as esters and nonamino nitrogen derivatives such as amides or nitriles; k is an integer of one to eight; Y is a straight or substituted aliphatic chain haivng from two to eight carbon atoms which may have one or more S--S groups interposed therebetween; m signifies the number of carbon atoms in an aliphatic chain Y containing 2 to 8 carbon stoms which may have S--S interposed; aliphatic chain Y, substituted with one or more polar groups of the number k is attached to one of the two sulfur atoms shown. The second sulfur atom is attached through an aliphatic chain of 2 to 5 carbon atoms to the sulfinate function SO.sub.2 M wherein R.sup.1 and R.sup.2 may be hydrogen, aryl, cycloalkyl or various polar groups such as OH, COOH, SO.sub.3 Na, --C(O)--, or derivatives such as esters and nonamino derivatives such as amides or nitriles. The system ##STR2## also may comprise an aromatic ring; n may be the integers 2 through 6; M of the sulfinate function is hydrogen, a metallic element selected from group 1 A of the Periodic Table such as Li, Na, or K, or the equivalent R.sub.4 N+; or an organic group such as a straight or substituted aliphatic chain having up to 4 carbon atoms, designed to promote stability. The synthesis of the compounds occurs by subjecting 1,1-dioxides of cyclic disulfidesto the action of a thiolate ion, whereby cleavage is effected between the sulfur and sulfonyl units.

    摘要翻译： 可用作抗辐射剂的非对称有机二硫化物亚磺酸盐化合物，具有以下通式：其中A是一个或以下极性基团，OH，COOH，SO 3 Na，-C（O） - 或衍生物，例如酯和 非氨基氮衍生物如酰胺或腈; k是1到8的整数; Y是可以具有两个至八个碳原子的直链或取代的脂族链，它们之间可以具有一个或多个S-S基团; m表示含有可插入S-S的2〜8个碳原子的脂族链Y中的碳原子数; 由数个k的一个或多个极性基团取代的脂族链Y连接到所示的两个硫原子中的一个上。 第二硫原子通过2至5个碳原子的脂族链连接到亚磺酸盐官能团SO 2 M上，其中R 1和R 2可以是氢，芳基，环烷基或各种极性基团，例如OH，COOH，SO 3 N a，-C（O） - ，或衍生物如酯和非氨基衍生物如酰胺或腈。 系统还可以包括芳环; n可以是整数2到6; 亚硫酸盐官能团的M为氢，选自元素周期表的一种元素的金属元素如Li，Na或K，或当量的R4N +; 或有机基团，例如具有至多4个碳原子的直链或取代的脂族链，旨在促进稳定性。 化合物的合成通过使环状二硫化物的1,1-二氧化物进行硫醇盐离子的作用而发生，由此在硫和磺酰基单元之间进行切割。