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公开(公告)号：US07033588B2
公开(公告)日：2006-04-25
申请号：US10483934
申请日：2002-07-17
IPC分类号： A61K38/43
CPC分类号： A61K9/0095 , A61K31/122 , A61K47/14 , A61K47/44
摘要： It is intended to provide a preventive agent for ascites containing coenzyme Q which can sufficiently exert an effect on preventing ascites even when administering in a small dose and within a short period of time, and the preventive agent for ascites which can be effectively administered to poultry using a simple method. Namely, preventive agent for ascites in poultry containing coenzyme Q and a surfactant, wherein the content of the surfactant is in a range of between 0.5 and 80 parts by weight with respect to a total amount of the preventive agent for ascites.
摘要翻译： 本发明提供一种含有辅酶Q的腹水预防剂，其即使在小剂量和短时间内施用时也能充分发挥防止腹水的作用，并且可以有效地施用于家禽的腹水预防剂 使用简单的方法。 即，含有辅酶Q的家禽中的腹水预防剂和表面活性剂，其中表面活性剂的含量相对于腹水预防剂的总量为0.5〜80重量份。
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公开(公告)号：US07026361B2
公开(公告)日：2006-04-11
申请号：US10213108
申请日：2002-08-07
CPC分类号： A61K9/10 , A61K9/0095 , A61K9/145 , A61K9/146 , A61K31/122 , Y10S514/937
摘要： This invention relates to a composition comprising ubiquinone having superior dispersion-stability in an aqueous solution and high bioavailability. The ubiquinone(s) is dispersed and emulsified in an aqueous solution of a water-soluble material in the presence of an organic acid(s) to form a protective colloid, the average particle size of the suspended particles being not more than 5 μm. The liquid composition can be adsorbed in or carried on an excipient, or dried.
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公开(公告)号：US20060073176A1
公开(公告)日：2006-04-06
申请号：US10537433
申请日：2003-12-02
申请人： Takeshi Segawa , Atsuke Abe , Tsuyoshi Minemura , Hironori Kubota
发明人： Takeshi Segawa , Atsuke Abe , Tsuyoshi Minemura , Hironori Kubota
CPC分类号： A61K31/122 , A23L29/10 , A23L33/10 , A23L33/115 , A61K8/355 , A61K8/375 , A61K9/08 , A61K47/14 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： A water-soluble composition comprising (A) coenzyme Q10 of 5-40% by weight, (B) monoester of polyglycerol with average polymerization degree of 10 and fatty acid with 18 carbon atoms of 5-30% by weight, (C) mono-, di-, tri- or penta-ester of polyglycerol with average polymerization degree of 3-6 and fatty acid with 18 carbon atoms of 1-18% by weight, and (D) water, wherein its average particle diameter is 110 nm or smaller. It is superior in acid resistance, salt-resistance and heat resistance, and further enables to maintain the good water-soluble state being blended to medicines, foods and beverages, cosmetics, feeds, additives usually employed therein.
摘要翻译： 一种水溶性组合物，其包含（A）5-40重量％的辅酶Q 10，（B）平均聚合度为10的聚甘油单酯和具有18个碳原子的脂肪酸为5-30 （C）平均聚合度为3-6的聚甘油的一，二，三或五酯，和18个碳原子的脂肪酸为1-18重量％，和（D）水， 其平均粒径为110nm以下。 耐酸性，耐盐性和耐热性优异，并且还能够将通常使用的药物，食品和饮料，化妆品，饲料，添加剂中的添加剂保持良好的水溶性状态。
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公开(公告)号：US07470436B2
公开(公告)日：2008-12-30
申请号：US10537433
申请日：2003-12-02
申请人： Takeshi Segawa , Atsuko Abe , Tsuyoshi Minemura , Hironori Kubota
发明人： Takeshi Segawa , Atsuko Abe , Tsuyoshi Minemura , Hironori Kubota
CPC分类号： A61K31/122 , A23L29/10 , A23L33/10 , A23L33/115 , A61K8/355 , A61K8/375 , A61K9/08 , A61K47/14 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： A water-soluble composition comprising (A) coenzyme Q10 of 5-40% by weight, (B) monoester of polyglycerol with average polymerization degree of 10 and fatty acid with 18 carbon atoms of 5-30% by weight, (C) mono-, di-, tri- or penta-ester of polyglycerol with average polymerization degree of 3-6 and fatty acid with 18 carbon atoms of 1-18% by weight, and (D) water, wherein its average particle diameter is 110 nm or smaller. It is superior in acid resistance, salt-resistance and heat resistance, and further enables to maintain the good water-soluble state being blended to medicines, foods and beverages, cosmetics, feeds, additives usually employed therein.
摘要翻译： 一种水溶性组合物，其包含（A）5-40重量％的辅酶Q10，（B）平均聚合度为10的聚甘油单酯和5-30重量％的碳原子的脂肪酸，（C）单 - ，平均聚合度为3-6的聚甘油的二 - ，三 - 或五 - 酯，和18个碳原子的脂肪酸为1-18重量％，和（D）水，其平均粒径为110nm 或更小。 耐酸性，耐盐性和耐热性优异，并且还能够将通常使用的药物，食品和饮料，化妆品，饲料，添加剂中的添加剂保持良好的水溶性状态。
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5.发明授权Stabilized pharmaceutical composition containing an isocarbostyril derivative 失效含有异卡波斯特尔衍生物的稳定化药物组合物
公开(公告)号：US4666919A
公开(公告)日：1987-05-19
申请号：US758820
申请日：1985-07-25
申请人： Masao Ueno , Hironori Kubota
发明人： Masao Ueno , Hironori Kubota
IPC分类号： C07D217/24 , A61K31/47 , A61K31/472 , A61K47/02 , A61P9/00
CPC分类号： A61K31/47 , A61K47/02 , Y10S514/97
摘要： A stabilized pharmaceutical composition containing 4-(3-tert.-butylamino-2-hydroxy)propoxy-2-methylisocarbostyril or an acid addition salt thereof as the active ingredient is now provided, in which the active ingredient compound is stabilized by addition of at least one of stabilizing agents selected from magnesium silicate, magnesium oxide, hydrotalcite and sodium hydrogen carbonate.
摘要翻译： 现提供一种含有4-（3-叔丁基氨基-2-羟基）丙氧基-2-甲基异卡波尔特或其酸加成盐作为有效成分的稳定化药物组合物，其中活性成分化合物通过加入 选自硅酸镁，氧化镁，水滑石和碳酸氢钠的至少一种稳定剂。
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