公开(公告)号：US08575189B2

公开(公告)日：2013-11-05

申请号：US13122820

申请日：2009-10-07

申请人： Hironori Masui ,  Shimpei Sato

发明人： Hironori Masui ,  Shimpei Sato

IPC分类号： A61K31/44

CPC分类号： A61K31/706 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/06 ,  A61K47/44

摘要： The present invention provides tacrolimus containing ointment having low dermal irritation and excellent stability. It was found that an ointment comprising triacetin as a solubilizer for tacrolimus may sufficiently solubilize tacrolimus, has low dermal irritation and excellent stability. Preferably, the ointment of the present invention is an o/o type (oil-in-oil type) ointment in which tacrolimus-solubilized triacetin droplets are dispersed in an ointment base, preferably a mixture of beeswax and petrolatum.

摘要翻译： 本发明提供具有低皮肤刺激性和优异稳定性的含有他克莫司的软膏。 发现包含三醋精作为他克莫司的增溶剂的软膏可以充分溶解他克莫司，具有低皮肤刺激性和优异的稳定性。 优选地，本发明的软膏是其中将他克莫司溶解的三醋精液滴分散在软膏基质，优选蜂蜡和凡士林的混合物中的o / o型（油包油型）软膏剂。

公开(公告)号：US20110212988A1

公开(公告)日：2011-09-01

申请号：US13122820

申请日：2009-10-07

申请人： Hironori Masui ,  Shimpei Sato

发明人： Hironori Masui ,  Shimpei Sato

IPC分类号： A61K31/439 ,  A61P37/06 ,  A61P31/00 ,  A61P17/00

CPC分类号： A61K31/706 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/06 ,  A61K47/44

摘要： The present invention provides tacrolimus containing ointment having low dermal irritation and excellent stability. It was found that an ointment comprising triacetin as a solubilizer for tacrolimus may sufficiently solubilize tacrolimus, has low dermal irritation and excellent stability. Preferably, the ointment of the present invention is an o/o type (oil-in-oil type) ointment in which tacrolimus-solubilized triacetin droplets are dispersed in an ointment base, preferably a mixture of beeswax and petrolatum.

摘要翻译： 本发明提供具有低皮肤刺激性和优异稳定性的含有他克莫司的软膏。 发现包含三醋精作为他克莫司的增溶剂的软膏可以充分溶解他克莫司，具有低皮肤刺激性和优异的稳定性。 优选地，本发明的软膏是其中将他克莫司溶解的三醋精液滴分散在软膏基质，优选蜂蜡和凡士林的混合物中的o / o型（油包油型）软膏剂。

公开(公告)号：US20060201271A1

公开(公告)日：2006-09-14

申请号：US11342830

申请日：2006-01-31

申请人： Hironori Masui

发明人： Hironori Masui

IPC分类号： F16H55/18

CPC分类号： F16H55/18 ,  Y10S74/10 ,  Y10T74/19623 ,  Y10T74/19633 ,  Y10T74/19949 ,  Y10T74/19958 ,  Y10T74/19972

摘要： A resin-made gearing apparatus that includes a configuration in which only one tooth flank side of each tooth in one of a pair of gears is provided with an overhang section that is disposed on at least one end portion in a tooth width direction, and overhangs diagonally from the one tooth flank side toward the adjacent tooth side; an end portion in a tooth width direction of each tooth in the other gear is provided with a lightening section that is disposed in a tooth flank of each tooth on an end face on the side of the end portion corresponding to the overhang section of the one gear, so that when the opposite teeth of the pair of gears are meshed with each other, the overhang section of the one gear is elastically deformed and also the lightening section of the other gear is elastically deformed, to absorb a backlash. Thus, the backlash appearing at the meshing of the pair of rein-made gears is absorbed by a backlash absorbing section comprised of the overhang section and the lightening section, and also, the deformation of and stress in the backlash absorbing section are reduced.

公开(公告)号：US07025347B2

公开(公告)日：2006-04-11

申请号：US10660624

申请日：2003-09-12

申请人： Hironori Masui ,  Kazuhide Sugiyama ,  Jun Tanaka

发明人： Hironori Masui ,  Kazuhide Sugiyama ,  Jun Tanaka

IPC分类号： B65H9/04

CPC分类号： B65H3/62 ,  B65H1/02 ,  B65H2403/512

摘要： A sheet feeding apparatus in which after a bundle of sheets is placed in an erect posture on a sheet supporting stand, the bundle of sheets placed on the sheet supporting stand is continuously vibrated upward and downward for a predetermined time, and is moved in a sheet feeding direction by an aligning portion to be hit against a hitting portion, and the bottom edges and the side edges of the bundle of sheets are accordingly aligned.

摘要翻译： 一种片材进给装置，其中在一束片材以直立的姿势放置在片材支撑台上时，放置在片材支撑台上的片材束在上下不间断地连续振动预定时间，并且在片材中移动 通过对准部分的进给方向撞击打击部分，并且片束的底部边缘和侧边缘因此对准。

公开(公告)号：US07526977B2

公开(公告)日：2009-05-05

申请号：US11342830

申请日：2006-01-31

申请人： Hironori Masui

发明人： Hironori Masui

IPC分类号： F16H55/06

CPC分类号： F16H55/18 ,  Y10S74/10 ,  Y10T74/19623 ,  Y10T74/19633 ,  Y10T74/19949 ,  Y10T74/19958 ,  Y10T74/19972

摘要： A resin-made gearing apparatus that includes a configuration in which only one tooth flank side of each tooth in one of a pair of gears is provided with an overhang section that is disposed on at least one end portion in a tooth width direction, and overhangs diagonally from the one tooth flank side toward the adjacent tooth side; an end portion in a tooth width direction of each tooth in the other gear is provided with a lightening section that is disposed in a tooth flank of each tooth on an end face on the side of the end portion corresponding to the overhang section of the one gear, so that when the opposite teeth of the pair of gears are meshed with each other, the overhang section of the one gear is elastically deformed and also the lightening section of the other gear is elastically deformed, to absorb a backlash. Thus, the backlash appearing at the meshing of the pair of rein-made gears is absorbed by a backlash absorbing section comprised of the overhang section and the lightening section, and also, the deformation of and stress in the backlash absorbing section are reduced.

摘要翻译： 一种树脂制齿轮装置，其包括：一对齿轮中的一个齿轮中的每个齿的仅一个齿面侧设置有设置在齿宽度方向上的至少一个端部的突出部，并且突出 对角地从一个齿侧面朝向相邻的齿侧; 在另一个齿轮中的每个齿的齿宽方向上的端部设置有减轻部，该减轻部设置在与各个齿的突出部对应的端部的一侧的端面上的各齿的齿面 齿轮，使得当一对齿轮的相对齿相互啮合时，一个齿轮的伸出部分弹性变形，另一个齿轮的减重部分也弹性变形，以吸收齿隙。 因此，出现在一对重制齿轮的啮合处的齿隙被由突出部分和减重部分组成的齿隙吸收部分吸收，并且齿隙吸收部分的变形和应力减小。