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公开(公告)号:US07850976B2
公开(公告)日:2010-12-14
申请号:US12041279
申请日:2008-03-03
申请人: Takashi Kadowaki , Toshimasa Yamauchi , Junji Kamon , Hironori Waki , Ryozo Nagai , Satoshi Kimura , Motoo Tomita
发明人: Takashi Kadowaki , Toshimasa Yamauchi , Junji Kamon , Hironori Waki , Ryozo Nagai , Satoshi Kimura , Motoo Tomita
CPC分类号: A61K38/2264
摘要: The invention provides an insulin resistance improving agent and a therapeutic agent for type 2 diabetes, which contain a C-terminal globular domain of adiponectin, adiponectin, or a gene for the domain or adiponectin. The invention also provides a method for improving insulin resistance and treating type 2 diabetes by administering the aforementioned agent(s).
摘要翻译: 本发明提供胰岛素抵抗改善剂和2型糖尿病治疗剂,其含有脂联素的C末端球状结构域,脂联素或结合域或脂联素的基因。 本发明还提供了一种通过施用上述药物来改善胰岛素抵抗和治疗2型糖尿病的方法。
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公开(公告)号:US20110065780A1
公开(公告)日:2011-03-17
申请号:US12906374
申请日:2010-10-18
申请人: Takashi KADOWAKI , Toshimasa Yamauchi , Junji Kamon , Hironori Waki , Ryozo Nagai , Satoshi Kimura , Motoo Tomita
发明人: Takashi KADOWAKI , Toshimasa Yamauchi , Junji Kamon , Hironori Waki , Ryozo Nagai , Satoshi Kimura , Motoo Tomita
IPC分类号: A61K31/7084 , A61P3/10
CPC分类号: A61K38/2264
摘要: The invention provides an insulin resistance improving agent and a therapeutic agent for type 2 diabetes, which contain a C-terminal globular domain of adiponectin, adiponectin, or a gene for the domain or adiponectin. The invention also provides a method for improving insulin resistance and treating type 2 diabetes by administering the aforementioned agent(s).
摘要翻译: 本发明提供胰岛素抵抗改善剂和2型糖尿病治疗剂,其含有脂联素的C末端球状结构域,脂联素或结合域或脂联素的基因。 本发明还提供了一种通过施用上述药物来改善胰岛素抵抗和治疗2型糖尿病的方法。
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公开(公告)号:US20100120674A1
公开(公告)日:2010-05-13
申请号:US12041279
申请日:2008-03-03
申请人: TAKASHI KADOWAKI , TOSHIMASA YAMAUCHI , JUNJI KAMON , HIRONORI WAKI , RYOZO NAGAI , SATOSHI KIMURA , MOTOO TOMITA
发明人: TAKASHI KADOWAKI , TOSHIMASA YAMAUCHI , JUNJI KAMON , HIRONORI WAKI , RYOZO NAGAI , SATOSHI KIMURA , MOTOO TOMITA
CPC分类号: A61K38/2264
摘要: The invention provides an insulin resistance improving agent and a therapeutic agent for type 2 diabetes, which contain a C-terminal globular domain of adiponectin, adiponectin, or a gene for the domain or adiponectin. The invention also provides a method for improving insulin resistance and treating type 2 diabetes by administering the aforementioned agent(s).
摘要翻译: 本发明提供胰岛素抵抗改善剂和2型糖尿病治疗剂,其含有脂联素的C末端球状结构域,脂联素或结合域或脂联素的基因。 本发明还提供了一种通过施用上述药物来改善胰岛素抵抗和治疗2型糖尿病的方法。
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公开(公告)号:US20060199761A1
公开(公告)日:2006-09-07
申请号:US10502051
申请日:2002-07-26
申请人: Takashi Kadowaki , Toshimasa Yamauchi , Junji Kamon , Hironori Waki , Ryozo Nagai , Satoshi Kimura , Motto Tomita
发明人: Takashi Kadowaki , Toshimasa Yamauchi , Junji Kamon , Hironori Waki , Ryozo Nagai , Satoshi Kimura , Motto Tomita
CPC分类号: A61K38/2264
摘要: The invention provides an insulin resistance improving agent which contains, as an active component, a C-terminal globular domain of adiponectin, adiponectin, or a gene for the domain or adiponectin. The invention also provides a therapeutic agent for type 2 diabetes, which contains, as an active component, a C-terminal globular domain of adiponectin, adiponectin, or a gene for the domain or adiponectin. The invention reverses insulin resistance induced from a high fat diet and associated with obesity, and therefore, enables treatment of type 2 diabetes, which is the most common among other types of diabetes.
摘要翻译: 本发明提供一种胰岛素抵抗性改善剂,其包含作为活性成分的脂联素的C末端球状结构域,脂联素或所述结构域或脂联素的基因。 本发明还提供了用于2型糖尿病的治疗剂,其包含作为活性成分的脂联素的C末端球状结构域,脂联素或所述结构域或脂联素的基因。 本发明逆转高脂肪饮食诱发的胰岛素抵抗并与肥胖相关,因此能够治疗其它类型糖尿病中最常见的2型糖尿病。
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