公开(公告)号：US4599333A

公开(公告)日：1986-07-08

申请号：US591904

申请日：1984-03-22

申请人： Kikuo Yasuda ,  Takayuki Takezaki ,  Rikio Ohuchi ,  Hiroshi Ohuyabu ,  Yoshitaka Tanimoto ,  Toshimi Seki ,  Takashi Yamaguchi ,  Akihiro Izumi ,  Norio Himori ,  Tsutomu Ishimori

发明人： Kikuo Yasuda ,  Takayuki Takezaki ,  Rikio Ohuchi ,  Hiroshi Ohuyabu ,  Yoshitaka Tanimoto ,  Toshimi Seki ,  Takashi Yamaguchi ,  Akihiro Izumi ,  Norio Himori ,  Tsutomu Ishimori

IPC分类号： C07D237/20 ,  C07D237/22 ,  A61K31/50

CPC分类号： C07D237/20 ,  C07D237/22

摘要： A hydrazinopyridazine compound represented by the formula ##STR1## wherein R.sup.1 represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a hydroxyl, lower alkoxy, lower alkylthio, lower alkanoylamino, allyloxy or tetrahydrofurfuryloxy group, a lower alkoxy group which may optionally be substituted by a 2-furyl, phenyl or lower alkoxy group, a lower alkenyl group, a lower alkenyloxy group, or a lower alkynyl group; R.sup.2 represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, a lower alkenyl group, or a lower alkenyloxy group; R.sup.3, R.sup.4 and R.sup.5, independently from each other, represent a hydrogen atom, a halogen atom, a lower alkyl group which may optionally be substituted by a lower alkoxy group, or a lower alkoxy group; R.sup.6 and R.sup.7, independently from each other, represent a hydrogen atom or a methyl group; Y represents --NH.sub.2, --NH--COOC.sub.2 H.sub.5, or ##STR2## Z represents --O--, --S--, or ##STR3## in which R.sup.8 represents a hydrogen atom or a lower alkyl group; and n is 1 or 2, or its salt; a process for the production the aforesaid compounds; and use of such compounds as antihypertensive agents.

摘要翻译： 由式（I）表示的肼基哒嗪化合物，其中R 1表示氢原子，卤素原子，羟基，氰基，可任选被卤素原子或羟基取代的低级烷基，低级 烷氧基，低级烷硫基，低级烷酰基氨基，烯丙氧基或四氢呋喃氧基，可任选被2-呋喃基，苯基或低级烷氧基，低级烯基，低级烯氧基或低级炔基取代的低级烷氧基; R 2表示氢原子，卤素原子，氰基，可以被卤素原子或低级烷氧基取代的低级烷基，低级烷氧基，低级链烯基或低级链烯氧基。 R 3，R 4和R 5彼此独立地表示氢原子，卤素原子，可以被低级烷氧基取代的低级烷基或低级烷氧基; R6和R7彼此独立地表示氢原子或甲基; Y表示-NH 2，-NH-COOC 2 H 5或Z表示-O - ， - S-或其中R 8表示氢原子或低级烷基的 和n为1或2，或其盐; 一种生产上述化合物的方法; 并使用这些化合物作为抗高血压药。