公开(公告)号：US4599333A

公开(公告)日：1986-07-08

申请号：US591904

申请日：1984-03-22

申请人： Kikuo Yasuda ,  Takayuki Takezaki ,  Rikio Ohuchi ,  Hiroshi Ohuyabu ,  Yoshitaka Tanimoto ,  Toshimi Seki ,  Takashi Yamaguchi ,  Akihiro Izumi ,  Norio Himori ,  Tsutomu Ishimori

发明人： Kikuo Yasuda ,  Takayuki Takezaki ,  Rikio Ohuchi ,  Hiroshi Ohuyabu ,  Yoshitaka Tanimoto ,  Toshimi Seki ,  Takashi Yamaguchi ,  Akihiro Izumi ,  Norio Himori ,  Tsutomu Ishimori

IPC分类号： C07D237/20 ,  C07D237/22 ,  A61K31/50

CPC分类号： C07D237/20 ,  C07D237/22

摘要： A hydrazinopyridazine compound represented by the formula ##STR1## wherein R.sup.1 represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a hydroxyl, lower alkoxy, lower alkylthio, lower alkanoylamino, allyloxy or tetrahydrofurfuryloxy group, a lower alkoxy group which may optionally be substituted by a 2-furyl, phenyl or lower alkoxy group, a lower alkenyl group, a lower alkenyloxy group, or a lower alkynyl group; R.sup.2 represents a hydrogen atom, a halogen atom, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a lower alkoxy group, a lower alkoxy group, a lower alkenyl group, or a lower alkenyloxy group; R.sup.3, R.sup.4 and R.sup.5, independently from each other, represent a hydrogen atom, a halogen atom, a lower alkyl group which may optionally be substituted by a lower alkoxy group, or a lower alkoxy group; R.sup.6 and R.sup.7, independently from each other, represent a hydrogen atom or a methyl group; Y represents --NH.sub.2, --NH--COOC.sub.2 H.sub.5, or ##STR2## Z represents --O--, --S--, or ##STR3## in which R.sup.8 represents a hydrogen atom or a lower alkyl group; and n is 1 or 2, or its salt; a process for the production the aforesaid compounds; and use of such compounds as antihypertensive agents.

摘要翻译： 由式（I）表示的肼基哒嗪化合物，其中R 1表示氢原子，卤素原子，羟基，氰基，可任选被卤素原子或羟基取代的低级烷基，低级 烷氧基，低级烷硫基，低级烷酰基氨基，烯丙氧基或四氢呋喃氧基，可任选被2-呋喃基，苯基或低级烷氧基，低级烯基，低级烯氧基或低级炔基取代的低级烷氧基; R 2表示氢原子，卤素原子，氰基，可以被卤素原子或低级烷氧基取代的低级烷基，低级烷氧基，低级链烯基或低级链烯氧基。 R 3，R 4和R 5彼此独立地表示氢原子，卤素原子，可以被低级烷氧基取代的低级烷基或低级烷氧基; R6和R7彼此独立地表示氢原子或甲基; Y表示-NH 2，-NH-COOC 2 H 5或Z表示-O - ， - S-或其中R 8表示氢原子或低级烷基的 和n为1或2，或其盐; 一种生产上述化合物的方法; 并使用这些化合物作为抗高血压药。

公开(公告)号：US4843072A

公开(公告)日：1989-06-27

申请号：US93033

申请日：1987-09-04

申请人： Kikuo Yasuda ,  Kenyu Shibata ,  Seijiro Honma ,  Toshimi Seki ,  Kohichi Hasumi ,  Takeshi Masuda ,  Akihiro Izumi ,  Tsutomu Ishimori ,  Kotaro Gotanda ,  Masako Uno

发明人： Kikuo Yasuda ,  Kenyu Shibata ,  Seijiro Honma ,  Toshimi Seki ,  Kohichi Hasumi ,  Takeshi Masuda ,  Akihiro Izumi ,  Tsutomu Ishimori ,  Kotaro Gotanda ,  Masako Uno

IPC分类号： A61K31/50 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14

CPC分类号： C07D237/04

摘要： A pyridazinone derivative represented by the following general formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, either one of R.sub.2, R.sub.3 and R.sub.4 represents a hydrogen atom and the remaining two of them represent a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and a salt thereof. The compounds are useful as antihypertensive agents.

摘要翻译： 由下列通式（I）表示的哒嗪酮衍生物，其中R1表示氢原子或甲基，R2，R3和R4中的任一个表示氢原子，其余两个表示低级烷基， 三氟甲基，卤素原子，氰基或硝基，及其盐。 该化合物可用作抗高血压药。

公开(公告)号：US5130314A

公开(公告)日：1992-07-14

申请号：US770287

申请日：1991-09-27

申请人： Kikuo Yasuda ,  Kenyu Shibata ,  Nobuyoshi Minami ,  Toshimi Seki ,  Masafumi Shiraiwa ,  Tomio Nakao ,  Katsuhiko Miyasaka ,  Tsutomu Ishimori ,  Kotaro Gotanda ,  Takako Sasaki

发明人： Kikuo Yasuda ,  Kenyu Shibata ,  Nobuyoshi Minami ,  Toshimi Seki ,  Masafumi Shiraiwa ,  Tomio Nakao ,  Katsuhiko Miyasaka ,  Tsutomu Ishimori ,  Kotaro Gotanda ,  Takako Sasaki

IPC分类号： C07D237/04 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D237/04 ,  C07D403/12

摘要： A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom,or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.

公开(公告)号：US5082844A

公开(公告)日：1992-01-21

申请号：US539741

申请日：1990-06-18

申请人： Kikuo Yasuda ,  Kenyu Shibata ,  Nobuyoshi Minami ,  Toshimi Seki ,  Masafumi Shiraiwa ,  Tomio Nakao ,  Katsuhiko Miyasaka ,  Tsutomu Ishimori ,  Kotaro Gotanda ,  Takako Sasaki

发明人： Kikuo Yasuda ,  Kenyu Shibata ,  Nobuyoshi Minami ,  Toshimi Seki ,  Masafumi Shiraiwa ,  Tomio Nakao ,  Katsuhiko Miyasaka ,  Tsutomu Ishimori ,  Kotaro Gotanda ,  Takako Sasaki

IPC分类号： C07D237/04 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D237/04 ,  C07D403/12

摘要： A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an asymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.

公开(公告)号：US5221674A

公开(公告)日：1993-06-22

申请号：US770288

申请日：1991-09-27

申请人： Kikuo Yasuda ,  Kenyu Shibata ,  Nobuyoshi Minami ,  Toshimi Seki ,  Masafumi Shiraiwa ,  Tomio Nakao ,  Katsuhiko Miyasaka ,  Tsutomu Ishimori ,  Kotaro Gotanda ,  Takako Sasaki

发明人： Kikuo Yasuda ,  Kenyu Shibata ,  Nobuyoshi Minami ,  Toshimi Seki ,  Masafumi Shiraiwa ,  Tomio Nakao ,  Katsuhiko Miyasaka ,  Tsutomu Ishimori ,  Kotaro Gotanda ,  Takako Sasaki

IPC分类号： C07D237/04 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D237/04 ,  C07D403/12

摘要： A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom,or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.

摘要翻译： 由通式（I）表示的哒嗪酮化合物，其中Ar是其中R 1，R 2和R 3可以相同或不同，并且各自表示氢原子，低级烷基，三氟甲基 基团，卤素原子，氰基或硝基，R 4表示氢原子，低级烷氧基或被低级烷氧基或氨基甲酰基取代的低级烷基，C *是不对称碳原子 ，或其盐。 该化合物可用于治疗循环系统疾病。