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公开(公告)号:US5691339A
公开(公告)日:1997-11-25
申请号:US424282
申请日:1995-04-21
IPC分类号: A61K31/44 , A61K31/4422 , A61K31/495 , A61K31/496 , C07D401/00
CPC分类号: A61K31/495 , A61K31/44 , A61K31/4422 , A61K31/496
摘要: A circulatory disorder improving agent comprising, as an active ingredient, a dihydropyridine derivative of the formula (I) ##STR1## or an acid addition salt thereof. Said circulatory disorder improving agent is particularly useful as an organ circulation disorder improving agent or peripheral circulation improving agent.
摘要翻译: PCT No.PCT / JP94 / 01412 Sec。 371日期1995年04月21日 102(e)日期1995年4月21日PCT 1994年8月25日PCT公布。 第WO95 / 05825号公报 日期:1995年3月2日循环障碍改善剂,其包含式(I)的二氢吡啶衍生物或其酸加成盐作为活性成分。 所述循环障碍改善剂特别可用作器官循环障碍改善剂或外周循环改善剂。
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公开(公告)号:US5888964A
公开(公告)日:1999-03-30
申请号:US637288
申请日:1996-04-24
CPC分类号: A61K38/57 , Y10S514/822 , Y10S514/929
摘要: A method for increasing the placental blood flow, which comprises administering a human-originated antithrombin-III. The human-originated antithrombin-III increases the placental blood flow in mammals and particularly improves intrauterine growth retardation caused by a decreased blood flow. The method is highly safe to the mother and fetus, since it uses human-originated AT-III as an active ingredient, thereby enabling effective and safe treatment of intrauterine growth retardation (IUGR) and the like.
摘要翻译: 一种增加胎盘血流量的方法,其包括施用人源起始的抗凝血酶III。 人源化的抗凝血酶III可增加哺乳动物的胎盘血流量,特别是改善由血流量减少引起的子宫内生长迟缓。 该方法对母体和胎儿是高度安全的,因为它使用人源AT-III作为活性成分,从而能够有效和安全地治疗子宫内发育迟缓(IUGR)等。
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公开(公告)号:US5856328A
公开(公告)日:1999-01-05
申请号:US915114
申请日:1997-08-20
IPC分类号: A61K31/44 , A61K31/4422 , A61K31/495 , A61K31/496 , C07D401/00
CPC分类号: A61K31/495 , A61K31/44 , A61K31/4422 , A61K31/496
摘要: A circulatory disorder improving agent comprising, as an active ingredient, a dihydropyridine derivative of the formula (I) ##STR1## or an acid addition salt thereof. Said circulatory disorder improving agent is particularly useful as an organ circulation disorder improving agent or peripheral circulation improving agent.
摘要翻译: 一种循环障碍改善剂,其包含作为活性成分的式(I)的二氢吡啶衍生物(I)或其酸加成盐。 所述循环障碍改善剂特别可用作器官循环障碍改善剂或外周循环改善剂。
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公开(公告)号:US5530001A
公开(公告)日:1996-06-25
申请号:US360705
申请日:1995-02-24
申请人: Masahide Nakajima , Norifumi Nakamura , Feng Wang , Koichi Yamanouchi , Kazutaka Hayashi , Hideaki Kido , Yoshiji Kubo , Minori Okita , Takeshi Uchida , Masahiro Watanabe , Katsumi Yamanaga , Hiroshi Shinyama , Toru Kawamura , Yuji Narita
发明人: Masahide Nakajima , Norifumi Nakamura , Feng Wang , Koichi Yamanouchi , Kazutaka Hayashi , Hideaki Kido , Yoshiji Kubo , Minori Okita , Takeshi Uchida , Masahiro Watanabe , Katsumi Yamanaga , Hiroshi Shinyama , Toru Kawamura , Yuji Narita
IPC分类号: A61K31/44 , A61K31/495
CPC分类号: A61K31/44 , A61K31/495 , Y10S514/824 , Y10S514/87 , Y10S514/925 , Y10S514/929
摘要: A novel pharmaceutical use of a dihydropyridine derivative of the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is an alkyl or the like; R.sub.4 is a hydrogen atom or the like; R.sub.5 is nitro, a halogenated alkyl, cyano or the like; X is a vinylene or an azomethine; A is an alkylene; and B is --N(R.sub.6) (R.sub.7) or a group of the formula ##STR2## wherein R.sub.6 and R.sub.7 are the same or different and each is an alkyl, an aralkyl, an aryl or the like; R.sub.8 and Ar are aryl or the like; and n is 0, 1 or 2, or an acid addition salt thereof for promoting PGI.sub.2 production, and for the treatment and prevention of hyperlipemia, arteriosclerosis and cerebral diseases.
摘要翻译: PCT No.PCT / JP94 / 00460 Sec。 371日期:1995年2月24日 102(e)日期1995年2月24日PCT 1994年3月22日PCT公布。 第WO94 / 23721号公报 日期:1994年10月27日。一种式(I)的二氢吡啶衍生物(Ⅰ)的新药用途,其中R 1,R 2和R 3相同或不同,各自为烷基等; R4是氢原子等; R5是硝基,卤代烷基,氰基等; X是亚乙烯基或偶氮甲碱; A是亚烷基; 并且B是-N(R6)(R7)或下式的基团:其中R6和R7相同或不同,并且各自是烷基,芳烷基,芳基等; R8和Ar是芳基等; 和n为0,1或2,或其酸加成盐,用于促进PGI2的产生,以及用于治疗和预防高脂血症,动脉硬化和脑疾病。
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