公开(公告)号：US20110014168A1

公开(公告)日：2011-01-20

申请号：US12745007

申请日：2007-11-29

申请人： Hirosi Tsuboi ,  Noriko Kaneko ,  Akina Satou ,  Yoshinobu Tsuchiya

发明人： Hirosi Tsuboi ,  Noriko Kaneko ,  Akina Satou ,  Yoshinobu Tsuchiya

IPC分类号： A61K35/74 ,  C12N1/20 ,  A61P1/00

CPC分类号： A23C9/1234 ,  A23C9/1238 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/61 ,  A61K35/747 ,  C12R1/225 ,  A23V2200/30

摘要： Various types of lactic acid bacteria were cultured in the presence of a purine, the amount of the purine consumed and the amount of purine degradation products produced were measured, and several lactic acid bacteria showing remarkable purine-decomposing ability were selected. Lactic acid bacteria that were assessed to have high purine-decomposing ability according to the above-mentioned selection were orally administered to rats reared on purine-containing feed, the general status and serum uric acid level of the rats were measured, and the effect of lactic acid bacteria administration on serum uric acid levels was examined. As a result, lactic acid bacteria that significantly suppress the increase of serum uric acid levels, Lactobacillus gasseri OLL2959 and Lactobacillus oris OLL2779, were found.

摘要翻译： 在嘌呤存在下培养各种类型的乳酸菌，测定嘌呤消耗量和产生的嘌呤降解产物量，选择显示出显着的嘌呤分解能力的几种乳酸菌。 对含有嘌呤的饲料饲养的大鼠口服给予根据上述选择被评估为具有高嘌呤分解能力的乳酸菌，测定大鼠的一般状态和血清尿酸水平， 检测乳酸菌对血清尿酸水平的影响。 结果发现显着抑制血清尿酸水平增加的乳酸菌，加氏乳杆菌OLL2959和乳酸杆菌OLL2779。