公开(公告)号：US20110281991A1

公开(公告)日：2011-11-17

申请号：US12977603

申请日：2010-12-23

Applicant: Chih-Wei CHOU ,  Chih-Hsiu Chen ,  Wen-Hsin Lin ,  Hong-Ru Lin ,  Te-Hsing Wu ,  Yang-Chia Shih

Inventor： Chih-Wei CHOU ,  Chih-Hsiu Chen ,  Wen-Hsin Lin ,  Hong-Ru Lin ,  Te-Hsing Wu ,  Yang-Chia Shih

IPC: C08L5/00 ,  C08K3/08 ,  C08F2/48 ,  B05D7/14 ,  C08F2/46

CPC classification number: C08L5/00 ,  B01J13/02 ,  B22F1/0018 ,  B22F1/0062 ,  B22F9/24 ,  B22F2999/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08B37/006 ,  B22F2202/11

Abstract: A method for manufacturing core-shell metal nanoparticles is provided. The method comprises providing a first solution containing a metal ion; providing a second solution containing Arabinogalactan and having a pH value ranging from about 1 to about 13; mixing the first solution and the second solution to form a third solution; and enabling the third solution to perform an oxidation-reduction reaction to form the core-shell metal nanoparticles. The core-shell metal nanoparticles comprise a core composed of metal; and a shell, composed of Arabinogalactan, covering the surface of he core.

Abstract translation: 提供了一种制造核 - 壳金属纳米粒子的方法。 该方法包括提供含有金属离子的第一溶液; 提供含有阿拉伯半乳聚糖并且具有约1至约13的pH值的第二溶液; 混合第一溶液和第二溶液以形成第三溶液; 并且使第三溶液进行氧化还原反应以形成核 - 壳金属纳米颗粒。 核 - 壳金属纳米颗粒包含由金属构成的核; 和一个由阿拉伯半乳糖组成的壳，覆盖其核心的表面。

公开(公告)号：US06511660B1

公开(公告)日：2003-01-28

申请号：US09725006

申请日：2000-11-29

Applicant: Hong-Ru Lin ,  Kuo-Chun Sung

Inventor： Hong-Ru Lin ,  Kuo-Chun Sung

IPC: A61K3174

CPC classification number: A61K31/74 ,  A61K9/0048 ,  Y10S514/912 ,  Y10S514/913

Abstract: The present invention provides novel ophthalmic drug delivery formulation which comprises a mixture of Carbopol and Pluronic. Carbopol is a trademark of B.F. Goodrich Company's high molecular weight carboxy vinyl polymers (MW above 1,000,000). Pluronic belongs to a class of block copolymers containing polyoxyethylene and polyoxypropylene. The preferred weight percentages of Carbopol and Pluronic in the ophthalmic drug delivery formulation are 0.3% of Carbopol and 14% of Pluronic. The ocular bioavailability is greatly enhanced by the use of the ophthalmic drug delivery formulation of the present invention.

Abstract translation: 本发明提供新的眼科药物递送制剂，其包含Carbopol和Pluronic的混合物。 Carbopol是B.F.Goodrich Company的高分子量羧基乙烯基聚合物（MW高于1,000,000）的商标。 普朗尼克属于一类含聚氧乙烯和聚氧丙烯的嵌段共聚物。 Carbopol和Pluronic在眼药物递送制剂中的优选重量百分比为0.3％Carbopol和14％Pluronic。 通过使用本发明的眼药物递送制剂，大大提高了眼部生物利用度。