公开(公告)号：US20110027345A1

公开(公告)日：2011-02-03

申请号：US12667915

申请日：2008-07-03

Applicant: Shuming Wang ,  Huiyong Xue ,  Li Wang ,  Enhong Zhang ,  Hongjun Lian ,  Xiaoyan Shi ,  Guohua Chi ,  Yucheng Lu ,  Xiquan Liu ,  Li Song ,  Xuying Zhong ,  Hongguang Du

Inventor： Shuming Wang ,  Huiyong Xue ,  Li Wang ,  Enhong Zhang ,  Hongjun Lian ,  Xiaoyan Shi ,  Guohua Chi ,  Yucheng Lu ,  Xiquan Liu ,  Li Song ,  Xuying Zhong ,  Hongguang Du

IPC: A61K31/381 ,  A61K9/00 ,  A61K9/70 ,  A61P25/16

CPC classification number: A61K9/7023 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/381

Abstract: The present invention relates to a composition containing Rotigotine and the use thereof in the manufacture of a Rotigotine-containing transdermal patch, wherein said composition is based on a matrix mixture system formed from a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive, and polyvinylpyrrolidone which are present in a particular weight ratio, wherein (1) the acrylic pressure-sensitive adhesive is present in an amount of about 1-25% by weight in the matrix mixture system, (2) the silicone pressure-sensitive adhesive is present in an amount of about 65-98% by weight in the matrix mixture system, and (3) the polyvinylpyrrolidone is present in an amount of about 1-10% by weight in the matrix mixture system, and comprises 1-40% of Rotigotine on the basis of the total weight of the composition. The present invention further relates to an improved transdermal patch containing Rotigotine comprising said composition. Said patch has improved properties in the solubility, release and initial penetration level of Rotigotine.

Abstract translation: 本发明涉及含有罗替高汀的组合物及其在制造含罗替尼汀的透皮贴剂中的用途，其中所述组合物是基于由丙烯酸压敏粘合剂与硅氧烷压敏粘合剂组合形成的基质混合物体系， 敏感性粘合剂和聚乙烯吡咯烷酮，其特征在于：（1）所述丙烯酸类压敏粘合剂在所述基质混合物体系中以约1-25％（重量）的量存在，（2） 在基质混合体系中，敏感粘合剂的存在量为约65-98重量％，（3）在基质混合体系中，聚乙烯吡咯烷酮的存在量为约1-10重量％，并且包含1- 基于组合物总重量的罗替高汀为40％。 本发明还涉及包含所述组合物的含有罗替高汀的改良透皮贴剂。 所述贴剂具有改善的罗替戈汀的溶解度，释放和初始渗透水平的性质。

公开(公告)号：US09265752B2

公开(公告)日：2016-02-23

申请号：US12667915

申请日：2008-07-03

Applicant: Shuming Wang ,  Huiyong Xue ,  Li Wang ,  Enhong Zhang ,  Hongjun Lian ,  Xiaoyan Shi ,  Guohua Chi ,  Yucheng Lu ,  Xiquan Liu ,  Li Song ,  Xuying Zhong ,  Hongguang Du

Inventor： Shuming Wang ,  Huiyong Xue ,  Li Wang ,  Enhong Zhang ,  Hongjun Lian ,  Xiaoyan Shi ,  Guohua Chi ,  Yucheng Lu ,  Xiquan Liu ,  Li Song ,  Xuying Zhong ,  Hongguang Du

IPC: A61K9/70 ,  A61K31/381 ,  A61P25/16

CPC classification number: A61K9/7023 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/381

Abstract: A Rotigotine-containing composition having a matrix mixture system formed from a polyvinylpyrrolidone and a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive. The polyvinylpyrrolidone may be present in an amount of about 1-10% by weight in matrix mixture system. The acrylic pressure-sensitive adhesive may be present in an amount of about 1-25% by weight in the matrix mixture system. The silicone pressure-sensitive adhesive may be present in an amount of about 65-98% by weight in the matrix mixture system. The composition further includes 1-40% of Rotigotine on the basis of the total weight of the composition. The composition provides improved properties in the solubility, release and initial penetration level of Rotigotine. Also disclosed is a transdermal patch that includes the Rotigotine-containing composition, as well as methods of manufacturing and using the Rotigotine-containing composition.

Abstract translation: 一种含有罗替那定的组合物，其具有由聚乙烯吡咯烷酮形成的基质混合物体系和丙烯酸类压敏粘合剂与硅氧烷压敏粘合剂的组合。 聚乙烯吡咯烷酮的存在量可以在基质混合体系中约1-10％（重量）。 丙烯酸类压敏粘合剂可以在基质混合物体系中以约1-25重量％的量存在。 在基质混合物体系中，硅氧烷压敏粘合剂可以以约65-98重量％的量存在。 该组合物还包括基于组合物总重量的1-40％的罗替戈汀。 该组合物提供了罗替戈汀的溶解度，释放和初始渗透水平的改善的性质。 还公开了包括含有罗替多汀的组合物的透皮贴剂，以及制造和使用含有罗替尼汀的组合物的方法。