公开(公告)号：US20110027345A1

公开(公告)日：2011-02-03

申请号：US12667915

申请日：2008-07-03

申请人： Shuming Wang ,  Huiyong Xue ,  Li Wang ,  Enhong Zhang ,  Hongjun Lian ,  Xiaoyan Shi ,  Guohua Chi ,  Yucheng Lu ,  Xiquan Liu ,  Li Song ,  Xuying Zhong ,  Hongguang Du

发明人： Shuming Wang ,  Huiyong Xue ,  Li Wang ,  Enhong Zhang ,  Hongjun Lian ,  Xiaoyan Shi ,  Guohua Chi ,  Yucheng Lu ,  Xiquan Liu ,  Li Song ,  Xuying Zhong ,  Hongguang Du

IPC分类号： A61K31/381 ,  A61K9/00 ,  A61K9/70 ,  A61P25/16

CPC分类号： A61K9/7023 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/381

摘要： The present invention relates to a composition containing Rotigotine and the use thereof in the manufacture of a Rotigotine-containing transdermal patch, wherein said composition is based on a matrix mixture system formed from a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive, and polyvinylpyrrolidone which are present in a particular weight ratio, wherein (1) the acrylic pressure-sensitive adhesive is present in an amount of about 1-25% by weight in the matrix mixture system, (2) the silicone pressure-sensitive adhesive is present in an amount of about 65-98% by weight in the matrix mixture system, and (3) the polyvinylpyrrolidone is present in an amount of about 1-10% by weight in the matrix mixture system, and comprises 1-40% of Rotigotine on the basis of the total weight of the composition. The present invention further relates to an improved transdermal patch containing Rotigotine comprising said composition. Said patch has improved properties in the solubility, release and initial penetration level of Rotigotine.

摘要翻译： 本发明涉及含有罗替高汀的组合物及其在制造含罗替尼汀的透皮贴剂中的用途，其中所述组合物是基于由丙烯酸压敏粘合剂与硅氧烷压敏粘合剂组合形成的基质混合物体系， 敏感性粘合剂和聚乙烯吡咯烷酮，其特征在于：（1）所述丙烯酸类压敏粘合剂在所述基质混合物体系中以约1-25％（重量）的量存在，（2） 在基质混合体系中，敏感粘合剂的存在量为约65-98重量％，（3）在基质混合体系中，聚乙烯吡咯烷酮的存在量为约1-10重量％，并且包含1- 基于组合物总重量的罗替高汀为40％。 本发明还涉及包含所述组合物的含有罗替高汀的改良透皮贴剂。 所述贴剂具有改善的罗替戈汀的溶解度，释放和初始渗透水平的性质。

公开(公告)号：US09265752B2

公开(公告)日：2016-02-23

申请号：US12667915

申请日：2008-07-03

申请人： Shuming Wang ,  Huiyong Xue ,  Li Wang ,  Enhong Zhang ,  Hongjun Lian ,  Xiaoyan Shi ,  Guohua Chi ,  Yucheng Lu ,  Xiquan Liu ,  Li Song ,  Xuying Zhong ,  Hongguang Du

发明人： Shuming Wang ,  Huiyong Xue ,  Li Wang ,  Enhong Zhang ,  Hongjun Lian ,  Xiaoyan Shi ,  Guohua Chi ,  Yucheng Lu ,  Xiquan Liu ,  Li Song ,  Xuying Zhong ,  Hongguang Du

IPC分类号： A61K9/70 ,  A61K31/381 ,  A61P25/16

CPC分类号： A61K9/7023 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/381

摘要： A Rotigotine-containing composition having a matrix mixture system formed from a polyvinylpyrrolidone and a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive. The polyvinylpyrrolidone may be present in an amount of about 1-10% by weight in matrix mixture system. The acrylic pressure-sensitive adhesive may be present in an amount of about 1-25% by weight in the matrix mixture system. The silicone pressure-sensitive adhesive may be present in an amount of about 65-98% by weight in the matrix mixture system. The composition further includes 1-40% of Rotigotine on the basis of the total weight of the composition. The composition provides improved properties in the solubility, release and initial penetration level of Rotigotine. Also disclosed is a transdermal patch that includes the Rotigotine-containing composition, as well as methods of manufacturing and using the Rotigotine-containing composition.

摘要翻译： 一种含有罗替那定的组合物，其具有由聚乙烯吡咯烷酮形成的基质混合物体系和丙烯酸类压敏粘合剂与硅氧烷压敏粘合剂的组合。 聚乙烯吡咯烷酮的存在量可以在基质混合体系中约1-10％（重量）。 丙烯酸类压敏粘合剂可以在基质混合物体系中以约1-25重量％的量存在。 在基质混合物体系中，硅氧烷压敏粘合剂可以以约65-98重量％的量存在。 该组合物还包括基于组合物总重量的1-40％的罗替戈汀。 该组合物提供了罗替戈汀的溶解度，释放和初始渗透水平的改善的性质。 还公开了包括含有罗替多汀的组合物的透皮贴剂，以及制造和使用含有罗替尼汀的组合物的方法。

公开(公告)号：US08071125B2

公开(公告)日：2011-12-06

申请号：US12096545

申请日：2005-12-09

申请人： Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

发明人： Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

IPC分类号： A61F13/00

CPC分类号： A61K9/7061 ,  A61K31/138 ,  A61K31/724

摘要： This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol.

摘要翻译： 本发明涉及层复合物形式的透皮贴剂，其包含背衬层，包含药理活性成分和药学上可接受的佐剂的药物储库层，以及覆盖药物储库层的释放衬垫，其特征在于药物 作为药理活性成分，含有硝酸异山梨酯和比索洛尔，比例为1:3〜3:1。 动物试验表明，所述贴片可以降低心电图T波的升高，血清中心肌酶水平的升高，以及通过在动物中连接冠状动脉引起的心肌梗塞范围的延长。 结果表明，所述贴片在治疗心血管疾病方面具有相当大的协同效应，对心脏上的几种不良事件具有良好的预防和治疗作用。 此外，动物试验表明，根据本发明的贴剂具有比仅含有硝酸异山梨酯和比洛维罗之一的贴剂的施用更好的减压效果，并且不会使应用容易引起的心律失常恶化 该补丁仅含有硝酸异山梨酯或比索洛尔。

公开(公告)号：US20080292685A1

公开(公告)日：2008-11-27

申请号：US12096545

申请日：2005-12-09

申请人： Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

发明人： Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

IPC分类号： A61K9/70 ,  A61K31/343 ,  A61P9/00

CPC分类号： A61K9/7061 ,  A61K31/138 ,  A61K31/724

摘要： This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol.

摘要翻译： 本发明涉及层复合物形式的透皮贴剂，其包含背衬层，包含药理活性成分和药学上可接受的佐剂的药物储库层，以及覆盖药物储库层的释放衬垫，其特征在于药物 作为药理活性成分，含有硝酸异山梨酯和比索洛尔，比例为1:3〜3:1。 动物试验表明，所述贴片可以降低心电图T波的升高，血清中心肌酶水平的升高，以及通过在动物中连接冠状动脉引起的心肌梗塞范围的延长。 结果表明，所述贴片在治疗心血管疾病方面具有相当大的协同效应，对心脏上的几种不良事件具有良好的预防和治疗作用。 此外，动物试验表明，根据本发明的贴剂具有比仅含有硝酸异山梨酯和比洛维罗之一的贴剂的施用更好的减压效果，并且不会使应用容易引起的心律失常恶化 该补丁仅含有硝酸异山梨酯或比索洛尔。

公开(公告)号：US07507337B2

公开(公告)日：2009-03-24

申请号：US11219073

申请日：2005-09-02

申请人： Miroslav Petro ,  Gary M. Diamond ,  Thomas Harding McWaid ,  Keith Anthony Hall ,  Li Song ,  Trevor G. Frank

发明人： Miroslav Petro ,  Gary M. Diamond ,  Thomas Harding McWaid ,  Keith Anthony Hall ,  Li Song ,  Trevor G. Frank

IPC分类号： B01D15/08

CPC分类号： G01N30/30 ,  B01D15/161 ,  B01D15/166 ,  G01N30/20 ,  G01N30/28 ,  G01N30/32 ,  G01N30/34 ,  G01N30/80

摘要： The invention relates to liquid chromatography techniques for rapidly characterizing samples, such as polymer solutions, emulsions and dispersions, and to devices for implementing such techniques. The system includes a design that provides the ability to perform chromatographic separations by using mobile phase composition gradients and temperature gradients during separations. The invention accomplishes this by providing mixing zones for a plurality of fluids as well as heated and chilled feeds feeding the fluids to the mixing zones. Additionally, the system provides the ability to analyze separated components with a detector and/or collect separated fractions into vessels of a fraction collector for further separation and/or analysis.

摘要翻译： 本发明涉及用于快速表征样品的液相色谱技术，例如聚合物溶液，乳液和分散体，以及用于实施这些技术的装置。 该系统包括通过在分离期间使用流动相组成梯度和温度梯度提供进行色谱分离的能力的设计。 本发明通过为多种流体提供混合区域以及将流体供给到混合区域的加热和冷冻进料来实现。 此外，该系统提供了利用检测器分析分离的组分和/或将分离的馏分收集到馏分收集器的容器中用于进一步分离和/或分析的能力。

公开(公告)号：US07274470B2

公开(公告)日：2007-09-25

申请号：US10898504

申请日：2004-07-23

申请人： Guylain Lemelin ,  Li Song ,  Dominique Beauchamp ,  David Jacques ,  Patryck Rouleau ,  Emmanuel Glasson ,  Patrick Dufour

发明人： Guylain Lemelin ,  Li Song ,  Dominique Beauchamp ,  David Jacques ,  Patryck Rouleau ,  Emmanuel Glasson ,  Patrick Dufour

IPC分类号： G01B11/24

CPC分类号： G01B11/2545 ,  G01B11/25 ,  G06T7/521

摘要： An optical 3D digitizer with an enlarged non-ambiguity zone, comprising a structured light projector for projecting a fringe pattern over a target area, the fringe pattern having a shiftable position over the target area is disclosed. First and second cameras having overlapping measurement fields are directed toward the target area and positioned with respect to the projector to define distinct triangulation planes therewith. The second camera has a larger non-ambiguity depth than the first camera. A computer evaluates a same set of camera-projector related functions from images captured by the cameras including the projected pattern at shifted positions, builds low depth resolution and degenerated 3D models from the camera-projector related functions evaluated with respect to the second and first cameras respectively, determines chromatic texture from the images, and builds a complete textured 3D model from data corresponding between the low depth resolution and degenerated 3D models within a tolerance range.

摘要翻译： 公开了一种具有放大的非歧义区域的光学3D数字化仪，其包括用于将目标区域上的条纹图案投影的结构化投光器，所述条纹图案具有在所述目标区域上方的可移位位置。 具有重叠测量场的第一和第二相机指向目标区域并相对于投影仪定位以与其定义明确的三角剖面。 第二台相机具有比第一台相机更大的非歧义深度。 计算机根据摄像机拍摄的图像评估相同的摄像机 - 投影仪相关功能，包括在偏移位置处的投影图案，从相对于第二和第一摄像机评估的相机投影仪相关功能构建低深度分辨率和退化3D模型 分别从图像中确定色彩纹理，并从容差范围内的低深度分辨率和退化3D模型之间的数据构建完整的纹理3D模型。

公开(公告)号：US20060280428A1

公开(公告)日：2006-12-14

申请号：US11405687

申请日：2006-04-17

申请人： Yun He ,  Quqing Chen ,  Jianfeng Xu ,  Jianwen Chen ,  Wengfang Fu ,  Xiaozhong Xu ,  Haiwu Zhao ,  Yong Chen ,  Weijia Zhu ,  Li Song

发明人： Yun He ,  Quqing Chen ,  Jianfeng Xu ,  Jianwen Chen ,  Wengfang Fu ,  Xiaozhong Xu ,  Haiwu Zhao ,  Yong Chen ,  Weijia Zhu ,  Li Song

IPC分类号： H04N5/93 ,  G11B27/00

CPC分类号： H04N19/577 ,  H04N19/132 ,  H04N19/159 ,  H04N19/172 ,  H04N19/46 ,  H04N19/61 ,  H04N19/70

摘要： The invention relates to a video encoding and decoding technical field of the signal processing, especially relates to a method for video clip assisted by clip identifier. The method defines a clip identifier on the video encoding and decoding rule as an identifier used specially for video stream clip. If the encoded video bit stream is clipped, then said clip identifier is inserted to the bit stream or used to replace the original identifier which functions as a start flag. The clip of the video bit stream can be operated conveniently by the invention. The features of the invention are: the bits, which mark whether the clipped video bit stream may be decoded and displayed incorrectly or not, are not required to appear in the unclipped bit stream; if it clips at a certain point of the bit stream, then said identifier will appear at this point to indicate that a problem in which the picture can not be decoded normally due to the predictive reference data being clipped may appear.

摘要翻译： 本发明涉及信号处理的视频编码和解码技术领域，特别涉及一种通过剪辑标识符辅助的视频剪辑的方法。 该方法将视频编码和解码规则上的剪辑标识符定义为专门用于视频流剪辑的标识符。 如果编码的视频比特流被剪切，则所述剪辑标识符被插入到比特流中，或者用于替换用作开始标志的原始标识符。 视频比特流的剪辑可以通过本发明方便地操作。 本发明的特征是：不需要在未剪切比特流中出现标记剪辑的视频比特流是否可能被不正确地解码和显示的比特; 如果它在比特流的特定点剪辑，则所述标识符将在此出现，以指示由于预测参考数据被剪切而不能正常解码图像的问题。

公开(公告)号：US06751519B1

公开(公告)日：2004-06-15

申请号：US10281433

申请日：2002-10-24

申请人： Akella V. S. Satya ,  Li Song ,  Robert Thomas Long ,  Kurt H. Weiner

发明人： Akella V. S. Satya ,  Li Song ,  Robert Thomas Long ,  Kurt H. Weiner

IPC分类号： G06F1900

CPC分类号： H01L22/20 ,  G01R31/2894 ,  G01R31/307 ,  H01L22/14 ,  H01L22/34

摘要： Disclosed are methods and apparatus for efficiently managing IC chip yield learning. In general terms, as each wafer lot moves through fabrication, yield information is obtained from each set of test structures for a particular process or defect mechanism. The nature of the yield information is such that it may be used directly or indirectly to predict product wafer test yield. In one implementation, the yield information includes a systematic yield (Y0), a defect density (DD), and a defect clustering factor (&agr;) determined based on the inspected test structure's yield. A running average of the yield information for each process or defect mechanism is maintained as each wafer lot is processed. As a particular wafer lot moves through the various processes, a product wafer-sort test yield may be predicted at any stage in the fabrication process based on the running-average yield information maintained for previously fabricated wafer lots.

摘要翻译： 公开了用于有效管理IC芯片产量学习的方法和装置。 一般来说，随着每个晶片批次移动通过制造，从特定工艺或缺陷机制的每组测试结构获得产量信息。 产量信息的性质可以直接或间接地用于预测产品晶圆测试产量。 在一个实施方案中，产量信息包括基于检验的测试结构的产量确定的系统产量（Y0），缺陷密度（DD）和缺陷聚类因子（α）。 当处理每个晶片批时，维持每个处理或缺陷机制的产量信息的运行平均值。 随着特定的晶片批次移动通过各种工艺，可以基于为先前制造的晶片批次保持的运行平均产量信息，在制造过程的任何阶段预测产品晶圆分选测试产量。

公开(公告)号：US07134459B2

公开(公告)日：2006-11-14

申请号：US10860113

申请日：2004-06-03

申请人： Eric Carlson ,  Li Song ,  Daniel M. Pinkas ,  Claus G. Lugmair

发明人： Eric Carlson ,  Li Song ,  Daniel M. Pinkas ,  Claus G. Lugmair

IPC分类号： B65B1/04

CPC分类号： B01F15/0445 ,  B01F3/188 ,  B01F13/0272 ,  B01F13/1055 ,  B01F15/0258 ,  B01F2015/0221 ,  B01F2215/0037 ,  B65B1/16 ,  B65B1/30 ,  G01G13/24

摘要： Method for preparing a mixed powder sample by mixing two or more different powders comprising transferring a quantity of a first powder to a mixing vessel and transferring a quantity of a second powder to the mixing vessel to form a powder bed in the mixing vessel comprising the first and second powders. The quantities of the powders are selected so the mixed sample has a predetermined ratio of first powder to second powder. The powder bed is fluidized to mix the powders and produce a mixed sample. The mixed sample weighs about 5 grams or less. The invention also includes apparatus for preparing mixed powder samples by mixing two or more different powders.

摘要翻译： 通过混合两种或多种不同的粉末来制备混合粉末样品的方法，包括将一定数量的第一粉末转移到混合容器中，并将一定量的第二粉末转移到混合容器中，以在混合容器中形成粉末床， 和第二粉末。 选择粉末的量，使得混合样品具有预定比例的第一粉末与第二粉末。 将粉末床流化以混合粉末并产生混合样品。 混合样品重约5克或更少。 本发明还包括通过混合两种或更多种不同粉末制备混合粉末样品的装置。

公开(公告)号：US20060188145A1

公开(公告)日：2006-08-24

申请号：US11340401

申请日：2006-01-26

申请人： Li Song ,  Guylain Lemelin ,  Sonya Delisle ,  Dominique Beauchamp ,  Patrick Dufour

发明人： Li Song ,  Guylain Lemelin ,  Sonya Delisle ,  Dominique Beauchamp ,  Patrick Dufour

IPC分类号： G06K9/00

CPC分类号： G06Q30/00 ,  B33Y30/00 ,  B33Y50/00

摘要： The present invention relates to method and apparatus for producing a personalized 3D object. The method comprises steps of detecting whether a payment has been received, inviting a user to select parameters by means of a user input device and a display, capturing at least two images of a subject, calculating a 3D image with the images captured, producing and delivering the personalized 3D object to the user. In addition, a receipt comprising a web site address, a password and a set of instructions for ordering additional products are delivered to the user and the 3D image and data are transferred to a server via a network connection. The apparatus, or kiosk, comprises a payment detector, a user input device and a display, an image acquisition system, calculators for calculating a 3D image, a manufacturing device and an exit for delivering the personalized 3D object to the user.

摘要翻译： 本发明涉及用于生产个性化3D对象的方法和装置。 该方法包括以下步骤：检测是否已经接收到支付，邀请用户通过用户输入设备和显示器选择参数，捕获被摄体的至少两个图像，使用捕获的图像计算3D图像，产生和 将个性化3D对象传递给用户。 此外，包括用于订购附加产品的网站地址，密码和一组指令的收据被传递给用户，并且3D图像和数据经由网络连接被传送到服务器。 该装置或信息亭包括支付检测器，用户输入装置和显示器，图像采集系统，用于计算3D图像的计算器，用于将个性化3D对象递送给用户的制造装置和出口。