公开(公告)号：US05998581A

公开(公告)日：1999-12-07

申请号：US290204

申请日：1999-04-12

申请人： Richard Alan Berglund ,  Nancy Anne Lockwood ,  Howard Eugene Magadanz ,  Hua Zheng

发明人： Richard Alan Berglund ,  Nancy Anne Lockwood ,  Howard Eugene Magadanz ,  Hua Zheng

IPC分类号： A61K38/00 ,  A61P31/00 ,  C07K9/00 ,  A61K38/14 ,  C07K5/12

CPC分类号： C07K9/008 ,  A61K38/00

摘要： This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial production of a copper complex of the glycopeptide antibiotic. Reductive alkylation of this complex favors regioselective alkylation and increased yields. Copper complexes of the glycopeptide antibiotic starting materials and of the alkylated products are also part of the invention.

公开(公告)号：US5952466A

公开(公告)日：1999-09-14

申请号：US968968

申请日：1997-11-12

申请人： Richard Alan Berglund ,  Nancy Anne Lockwood ,  Howard Eugene Magadanz ,  Hua Zheng

发明人： Richard Alan Berglund ,  Nancy Anne Lockwood ,  Howard Eugene Magadanz ,  Hua Zheng

IPC分类号： A61K38/00 ,  A61P31/00 ,  C07K9/00 ,  C07K5/12

CPC分类号： C07K9/008 ,  A61K38/00

摘要： This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics. The improvement residing in providing a source of copper which results in the initial production of a copper complex of the glycopeptide antibiotic. Reductive alkylation of this complex favors regioselective alkylation and increased yields. Copper complexes of the glycopeptide antibiotic starting materials and of the alkylated products are also part of the invention.

摘要翻译： 本发明涉及糖肽抗生素的还原烷基化改进方法。 提供的铜提供了一种铜的来源，导致糖肽抗生素的铜络合物的初始生产。 该复合物的还原烷基化有利于区域选择性烷基化和增加的产率。 糖肽抗生素原料和烷基化产物的铜络合物也是本发明的一部分。