公开(公告)号：US5858802A

公开(公告)日：1999-01-12

申请号：US684458

申请日：1996-07-19

申请人： Hui Chai-Gao ,  Reto Luginbuhl ,  Hans Sigrist ,  Nigel Skinner ,  Hendrik Van Den Vlekkert

发明人： Hui Chai-Gao ,  Reto Luginbuhl ,  Hans Sigrist ,  Nigel Skinner ,  Hendrik Van Den Vlekkert

IPC分类号： C07K17/14 ,  C12N11/14 ,  G01N33/543 ,  G01N33/551 ,  C12Q1/70 ,  G01N21/00

CPC分类号： C12N11/14 ,  C07K17/14 ,  G01N33/54353 ,  Y10S436/805 ,  Y10S436/806

摘要： The invention relates to a device including a substrate and at least one biologically active substance bound to at least a part of the surface of this substrate, which is obtained by simultaneous or sequential reaction of said substrate and of said substance with a bifunctional coupling agent in which one of the functional groups is capable of being photoactivated and generates carbenes and is used to bind the coupling agent to the inorganic substrate and the other functional group is used to bind the coupling agent to the biologically active substance, in which said substrate is a covalent inorganic nitride.

摘要翻译： 本发明涉及一种装置，其包括底物和至少一种生物活性物质，其结合至该基质表面的至少一部分，其通过所述底物和所述物质与双官能偶联剂的同时或顺序反应获得 其中一个官能团能够被光活化并产生卡宾，并且用于将偶联剂与无机基质结合，另一个官能团用于将偶联剂与生物活性物质结合，其中所述底物为 共价无机氮化物。

公开(公告)号：US20070026239A1

公开(公告)日：2007-02-01

申请号：US10569510

申请日：2004-08-26

申请人： Hans Sigrist ,  Francois Crevoisier ,  Hui Chai Gao ,  Mario Billia ,  Paul Raschle ,  Arie Bruinink

发明人： Hans Sigrist ,  Francois Crevoisier ,  Hui Chai Gao ,  Mario Billia ,  Paul Raschle ,  Arie Bruinink

IPC分类号： B32B17/06

CPC分类号： D06M15/03 ,  D06M10/00 ,  D06M10/025 ,  D06M15/15 ,  Y10T428/31612

摘要： Methods of chemical and biochemical functionalization of yarn and textile products are described. A yarn or textile product is contacted with a linker molecule comprising two or more photochemically activatable chemical groups and a non-linker molecule having a desired property. Photochemical activation of the chemical groups causes covalent attachment of the non-linker molecule to the yarn or textile product by means of the linker molecule in a single step. The methods are particularly useful for immobilization to yarn or textile of biomolecules that are susceptible to denaturation. Use of linker molecules derived from proteins or polysaccharides further minimizes denaturation of the biomolecule.

摘要翻译： 描述了纱线和纺织品的化学和生物化学功能化方法。 纱线或纺织产品与包含两个或多个光化学活化的化学基团的连接分子和具有所需性质的非连接分子接触。 化学基团的光化学活化通过单一步骤中的接头分子引起非连接分子与纱线或纺织产品共价连接。 该方法特别适用于固定在易于变性的生物分子的纱线或织物上。 使用衍生自蛋白质或多糖的接头分子进一步使生物分子的变性最小化。