公开(公告)号：US20070014858A1

公开(公告)日：2007-01-18

申请号：US11481749

申请日：2006-07-06

Applicant: Jen-Sen Wu ,  Yih-Yih Lin ,  Shou-Chiung Chen ,  Yi-Pin Huang ,  Hui-Ju Chan ,  Pei-Chun Kuo ,  Chun-Yu Lin

Inventor： Jen-Sen Wu ,  Yih-Yih Lin ,  Shou-Chiung Chen ,  Yi-Pin Huang ,  Hui-Ju Chan ,  Pei-Chun Kuo ,  Chun-Yu Lin

IPC: A61K9/46 ,  A61K9/24

CPC classification number: A61K9/0004 ,  A61K9/0007 ,  A61K9/2086

Abstract: An osmotically controlled delivery system includes a solid core having a shallow indentation on a surface of the core, and a semipermeable membrane enclosing the solid core. The solid core is made by a drug composition being caopable of generating an osmotically effective pressure, and the semipermeable membrane is relatively thinner at the shallow indentation. An in-situ exit passageway is formed in the indentation position when external aqueous fluids are imbibed through the semipermeable membrane into the dosage form by an osmotic pressure gradient. A process for forming an in-situ exit passageway of an osmotic delivery dosage form, a controlled onset dosage form, and a method for controlling the lag time of in-situ passageway formation are also disclosed.

Abstract translation: 渗透控制递送系统包括在芯的表面上具有浅凹陷的实心芯和包封实芯的半透膜。 固体核心由能够产生渗透有效压力的药物组合物制成，并且半透膜在浅凹陷处相对较薄。 当外部含水流体通过渗透压梯度吸入​​通过半透膜进入剂型时，在压痕位置形成原位离开通道。 还公开了一种用于形成渗透递送剂型的原位出口通道，受控起始剂型和控制原位通道形成的滞后时间的方法的方法。