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公开(公告)号：US10570088B2
公开(公告)日：2020-02-25
申请号：US15683739
申请日：2017-08-22
发明人： John R. Cashman , Jaroslaw Kalisiak
IPC分类号： C07C251/40 , C07C279/12 , C07C257/12 , C07C257/14 , C07C257/18 , C07D239/06 , C07D249/04 , C07D233/24
摘要： The invention describes pharmaceutical agents capable of crossing the blood brain barrier to protect against organophosphate pesticides and nerve agents or other electrophiles by reactivating inhibited cholinesterase (i.e., acetylcholinesterase and butyrylcholinesterase) and other proteins in the peripheral and central nervous system.
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公开(公告)号：US20170101441A1
公开(公告)日：2017-04-13
申请号：US15391614
申请日：2016-12-27
发明人： John R. Cashman , Mary T. MacDonald
摘要： Provided are methods for identifying OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts and compounds of Formula 1 for eliciting antibodies that specifically and selectively bind to the OP adducts, wherein the Formula 1 compounds have the structure of OP-Peptide-Linker-CP, wherein CP is a carrier protein, OP represents a structure corresponding to that of a reactive organic phosphorous compound covalently modifying a tyrosine residue hydroxyl group of the peptide of Formula I and the other variable groups are as described herein.
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公开(公告)号：US20170349538A1
公开(公告)日：2017-12-07
申请号：US15683739
申请日：2017-08-22
发明人： John R. Cashman , Jaroslaw Kalisiak
IPC分类号： C07C251/40 , C07D239/06 , C07C279/12 , C07C257/12 , C07C257/18 , C07C257/14 , C07D249/04 , C07D233/24
CPC分类号： C07C251/40 , C07C257/12 , C07C257/14 , C07C257/18 , C07C279/12 , C07D233/24 , C07D239/06 , C07D249/04
摘要： The invention describes pharmaceutical agents capable of crossing the blood brain barrier to protect against organophosphate pesticides and nerve agents or other electrophiles by reactivating inhibited cholinesterase (i.e., acetylcholinesterase and butyrylcholinesterase) and other proteins in the peripheral and central nervous system.
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