公开(公告)号：US20120071419A1

公开(公告)日：2012-03-22

申请号：US13264365

申请日：2010-04-14

申请人： Yoon Sup Choi ,  Jun Ho Chung ,  Ji Ho Yoo ,  Hyun Soo Cho ,  Su Min Yoon ,  Kyung Lock Kim ,  Sung Ho Ryu ,  Sang Uk Kim

发明人： Yoon Sup Choi ,  Jun Ho Chung ,  Ji Ho Yoo ,  Hyun Soo Cho ,  Su Min Yoon ,  Kyung Lock Kim ,  Sung Ho Ryu ,  Sang Uk Kim

IPC分类号： A61K38/02 ,  C07K1/00 ,  C12N15/12 ,  C12N15/63 ,  C07K14/47 ,  A61P35/00 ,  C12N1/19 ,  C12N1/15 ,  C12N1/21 ,  C07K14/00 ,  C12N5/10

CPC分类号： C07K14/485 ,  A61K38/00 ,  C07K1/00 ,  C12N15/1089 ,  C40B30/02 ,  G06F19/16 ,  G06F19/18 ,  G06F19/22

摘要： The present invention relates to a method for preparing a target-specific non-antibody protein, and more particularly, to a method for preparing a target-specific non-antibody protein comprising the steps of: selecting non-antibody proteins having a structural complementarity with the target site of a target protein in a non-antibody protein library; calculating a binding energy of the selected non-antibody protein and the target protein; selecting a non-antibody protein having a favorable binding energy among the selected non-antibody proteins; selecting amino acid residues having a high binding energy among the interfacial amino acid residues of the selected non-antibody protein and the target protein; and substituting the selected amino acid residues with the amino acid residues having a low binding energy. In addition, the present invention relates to a target-specific non-antibody specifically binding with EGFR (Epidermal Growth Factor Receptor) domain 2, which is prepared by the method, and a cancer therapeutic composition comprising the same.

摘要翻译： 本发明涉及一种制备靶特异性非抗体蛋白质的方法，更具体地涉及一种制备靶特异性非抗体蛋白质的方法，包括以下步骤：选择具有结构互补性的非抗体蛋白质 非抗体蛋白文库中靶蛋白的靶位点; 计算所选择的非抗体蛋白质和靶蛋白质的结合能; 选择所选非抗体蛋白质中具有良好结合能的非抗体蛋白质; 选择所选非抗体蛋白质的界面氨基酸残基与目标蛋白质之间具有高结合能的氨基酸残基; 并用具有低结合能的氨基酸残基代替所选择的氨基酸残基。 此外，本发明涉及通过该方法制备的与EGFR（表皮生长因子受体）结构域2特异性结合的靶特异性非抗体，以及含有该特异性抗体的癌症治疗组合物。

公开(公告)号：US09296802B2

公开(公告)日：2016-03-29

申请号：US13264365

申请日：2010-04-14

申请人： Yoon Sup Choi ,  Jun Ho Chung ,  Ji Ho Yoo ,  Hyun Soo Cho ,  Su Min Yoon ,  Kyung Lock Kim ,  Sung Ho Ryu ,  Sang Uk Kim

发明人： Yoon Sup Choi ,  Jun Ho Chung ,  Ji Ho Yoo ,  Hyun Soo Cho ,  Su Min Yoon ,  Kyung Lock Kim ,  Sung Ho Ryu ,  Sang Uk Kim

IPC分类号： C40B30/02 ,  C07K14/485 ,  C07K1/00 ,  C12N15/10 ,  G06F19/18 ,  A61K38/00 ,  G06F19/16 ,  G06F19/22

CPC分类号： C07K14/485 ,  A61K38/00 ,  C07K1/00 ,  C12N15/1089 ,  C40B30/02 ,  G06F19/16 ,  G06F19/18 ,  G06F19/22

摘要： The present invention relates to a method for preparing a target-specific non-antibody protein, and more particularly, to a method for preparing a target-specific non-antibody protein comprising the steps of: selecting non-antibody proteins having a structural complementarity with the target site of a target protein in a non-antibody protein library; calculating a binding energy of the selected non-antibody protein and the target protein; selecting a non-antibody protein having a favorable binding energy among the selected non-antibody proteins; selecting amino acid residues having a high binding energy among the interfacial amino acid residues of the selected non-antibody protein and the target protein; and substituting the selected amino acid residues with the amino acid residues having a low binding energy. In addition, the present invention relates to a target-specific non-antibody specifically binding with EGFR (Epidermal Growth Factor Receptor) domain 2, which is prepared by the method, and a cancer therapeutic composition comprising the same.

摘要翻译： 本发明涉及一种制备靶特异性非抗体蛋白质的方法，更具体地涉及一种制备靶特异性非抗体蛋白质的方法，包括以下步骤：选择具有结构互补性的非抗体蛋白质 非抗体蛋白文库中靶蛋白的靶位点; 计算所选择的非抗体蛋白质和靶蛋白质的结合能; 选择所选非抗体蛋白质中具有良好结合能的非抗体蛋白质; 选择所选非抗体蛋白质的界面氨基酸残基与目标蛋白质之间具有高结合能的氨基酸残基; 并用具有低结合能的氨基酸残基代替所选择的氨基酸残基。 此外，本发明涉及通过该方法制备的与EGFR（表皮生长因子受体）结构域2特异性结合的靶特异性非抗体，以及含有该特异性抗体的癌症治疗组合物。

公开(公告)号：US20120087258A1

公开(公告)日：2012-04-12

申请号：US13227072

申请日：2011-09-07

申请人： Hyeon LEE ,  Wang Chun KIM ,  Hyun Joon JEON ,  Jae Sam JUNG ,  Yong Jun CHO ,  Hyun Soo CHO

发明人： Hyeon LEE ,  Wang Chun KIM ,  Hyun Joon JEON ,  Jae Sam JUNG ,  Yong Jun CHO ,  Hyun Soo CHO

IPC分类号： H04W24/00

CPC分类号： H04W24/10 ,  H04W24/04

摘要： A user terminal and a method for managing data related to minimization of drive-tests (MDT) in the user terminal. The method includes entering into an MDT mode, receiving a system parameter from a base station, obtaining MDT-related data DN measured at a current time TN, and updating at least one of an average of the periodically measured MDT-related data ‘DAverage’ and information about distribution of the periodically measured MDT-related data ‘DDistribution’ to reflect DN based on the system parameter. The user terminal includes a measuring unit to measure DN, a memory unit to maintain at least one of ‘DAverage’ and ‘DDistribution’, based on a system parameter received from a base station; and a control unit to update at least one of the ‘DAverage’ and the ‘DDistribution’ based on DN measured at a current time TN.

摘要翻译： 用户终端和用于管理与用户终端中的驱动测试（MDT）最小化有关的数据的方法。 该方法包括进入MDT模式，从基站接收系统参数，获取在当前时间TN测量的MDT相关数据DN，以及更新周期性测量MDT相关数据平均值“DAverage”中的至少一个。 以及关于定期测量的MDT相关数据“DDistribution”的分布的信息，以基于系统参数反映DN。 用户终端包括测量单元，用于测量DN，存储器单元，用于基于从基站接收的系统参数来保持“数据分布”和“分配”中的至少一个; 以及控制单元，用于基于当前时间TN测量的DN更新“DAverage”和“DDistribution”中的至少一个。

公开(公告)号：US20120087259A1

公开(公告)日：2012-04-12

申请号：US13227813

申请日：2011-09-08

申请人： Wang Chun KIM ,  Hyeon LEE ,  Hyun Joon JEON ,  Jae Sam JUNG ,  Yong Jun CHO ,  Hyun Soo CHO

发明人： Wang Chun KIM ,  Hyeon LEE ,  Hyun Joon JEON ,  Jae Sam JUNG ,  Yong Jun CHO ,  Hyun Soo CHO

IPC分类号： H04W24/00 ,  H04L12/26

CPC分类号： H04W24/10

摘要： Provided is a method for obtaining and reporting minimization of drive-tests (MDT)-related data and an apparatus for performing the same. The method may include receiving mode signaling message related to performing of an MDT mode, obtaining MDT-related data for measuring a propagation environment around equipment, based on the MDT mode signaling message, maintaining and storing the MDT-related data in a memory, generating an MDT report message including at least one of an average of the MDT-related data DAverage and information about distribution of the MDT-related data DDistribution, and transmitting the MDT report message to a base station.

摘要翻译： 提供了一种用于获得和报告驱动测试（MDT）相关数据的最小化的方法以及用于执行该驱动测试的装置。 该方法可以包括接收与执行MDT模式有关的模式信令消息，根据MDT模式信令消息获取用于测量设备周围传播环境的MDT相关数据，维护和存储MDT相关数据到存储器中，生成 MDT报告消息，其包括MDT相关数据平均值平均值和关于MDT相关数据分发的分布的信息中的至少一个，以及向基站发送MDT报告消息。