公开(公告)号：US20180079752A1

公开(公告)日：2018-03-22

申请号：US15578775

申请日：2016-05-31

申请人： ADRIANUS PETRUS ANTONIUS DE MAN ,  RONALD KIM ,  JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  SOBHANA BABU BOGA ,  THIERRY FISCHMANN ,  DEODIAL Guy GUIADEEN ,  ILSE HENDRICA MARIA POLS-DE ROOIJ ,  SHILAN LIU ,  HAO WU

发明人： ADRIANUS PETRUS ANTONIUS DE MAN ,  RONALD KIM ,  JIAN LIU ,  JOSEPH A. KOZLOWSKI ,  SOBHANA BABU BOGA ,  THIERRY FISCHMANN ,  DEODIAL Guy GUIADEEN ,  ILSE HENDRICA MARIA POLS-DE ROOIJ ,  SHILAN LIU ,  HAO WU

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  A61P19/02

摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.