公开(公告)号：US10251611B2

公开(公告)日：2019-04-09

申请号：US14124752

申请日：2012-06-12

申请人： Rodney Ian McLeod Marsh ,  Richard Billett ,  Duncan Gilmore ,  Lydia Kay Goh ,  Raymond Lindsay Hope ,  Michael Steven McCallion ,  Ben McGarry ,  James Robert Ward

发明人： Rodney Ian McLeod Marsh ,  Richard Billett ,  Duncan Gilmore ,  Lydia Kay Goh ,  Raymond Lindsay Hope ,  Michael Steven McCallion ,  Ben McGarry ,  James Robert Ward

IPC分类号： A61B5/00 ,  A61B5/11

摘要： A freezing of gait cue apparatus that provides a visual cue, and a method for providing a visual cue, upon detection of a gait irregularity. The gait irregularity, such as a freeze of gait (FOG) for sufferers of neurological diseases like Parkinson's disease, is determined by a processor in communication with a motion sensor worn by the sufferer. When the gait irregularity is determined the apparatus projects a laser light beam on the ground in front of the user of the apparatus to cue them to continue walking.

公开(公告)号：US08845871B2

公开(公告)日：2014-09-30

申请号：US13529568

申请日：2012-06-21

申请人： John Chapples ,  John Anthony Tillotson ,  Ian McLeod ,  Martin Williamson

发明人： John Chapples ,  John Anthony Tillotson ,  Ian McLeod ,  Martin Williamson

IPC分类号： G01N27/413 ,  G01N27/404

CPC分类号： G01N27/404

摘要： An electrochemical oxygen sensor includes a micro-porous plastic membrane supported on a sealing disk and located between a gas inflow port and the sensor's electrolyte. The membrane and disk minimize thermal shock effects due to using the sensor at a first location, at a first temperature, and then moving it to a second location at a different temperature.

摘要翻译： 电化学氧传感器包括支撑在密封盘上并位于气体流入端口和传感器电解质之间的微孔塑料膜。 膜和盘片使得在第一温度下使用传感器的热冲击效应最小化，然后将其移动到不同温度的第二位置。

公开(公告)号：US20140249452A1

公开(公告)日：2014-09-04

申请号：US14124752

申请日：2012-06-12

申请人： Rodney Ian McLeod Marsh ,  Richard Billett ,  Duncan Bartlett Gilmore ,  Lydia Kay Goh ,  Raymond Lindsay Hope ,  Michael Steven McCallion ,  Ben McGarry ,  James Robert Ward

发明人： Rodney Ian McLeod Marsh ,  Richard Billett ,  Duncan Bartlett Gilmore ,  Lydia Kay Goh ,  Raymond Lindsay Hope ,  Michael Steven McCallion ,  Ben McGarry ,  James Robert Ward

IPC分类号： A61B5/00 ,  A61B5/11

CPC分类号： A61B5/7282 ,  A61B5/112 ,  A61B5/4082 ,  A61B5/6804 ,  A61B5/7257 ,  A61B5/742

摘要： A freezing of gait cue apparatus that provides a visual cue, and a method for providing a visual cue, upon detection of a gait irregularity. The gait irregularity, such as a freeze of gait (FOG) for sufferers of neurological diseases like Parkinson's disease, is determined by a processor in communication with a motion sensor worn by the sufferer. When the gait irregularity is determined the apparatus projects a laser light beam on the ground in front of the user of the apparatus to cue them to continue walking.

摘要翻译： 检测到步态不规则时，提供视觉提示的步态提示装置的冻结以及用于提供视觉提示的方法。 通过与患者佩戴的运动传感器通信的处理器确定步态不规则性，例如针对帕金森病等神经疾病患者的步态（FOG）的冻结。 当步态不规则被确定时，设备将激光束投射到设备使用者前面的地面上，以提示他们继续行走。

公开(公告)号：US08356822B2

公开(公告)日：2013-01-22

申请号：US13289910

申请日：2011-11-04

申请人： Ian McLeod ,  Pat McLeod

发明人： Ian McLeod ,  Pat McLeod

IPC分类号： A63C5/044

CPC分类号： A63C5/0417 ,  A63C5/03

摘要： Some embodiments are directed to a board for riding on a snow surface, comprising a base having a first snow engaging element, a second snow engaging element, and a third snow engaging element positioned on a bottom surface of the base. The first snow engaging element can be positioned beneath a user's front foot during operation of the board and positioned entirely on a forward half of the base. The second and third snow engaging elements can be positioned such that a fore portion of each is positioned beneath a user's front foot during operation of the board and extends toward the rear portion of the board at least to the user's rear foot. In some embodiments, the snow engaging elements can be protrusions, depressions, or otherwise, and can be removably supported by the base.

摘要翻译： 一些实施例涉及用于骑在雪地表面上的板，包括具有第一雪接合元件，第二雪接合元件的底座和位于底座的底表面上的第三雪接合元件。 在板的操作期间，第一个雪接合元件可以位于使用者的前脚下方，并且完全位于基座的前半部上。 第二和第三雪接合元件可以被定位成使得在板的操作期间每个的前部位于使用者的前脚下方，并且至少延伸到使用者的后脚的板的后部。 在一些实施例中，雪接合元件可以是突起，凹陷或其它方式，并且可以由底座可拆卸地支撑。

公开(公告)号：US20080202929A1

公开(公告)日：2008-08-28

申请号：US11877331

申请日：2007-10-23

申请人： John Chapples ,  John Anthony Tilloston ,  Ian McLeod ,  Martin Williamson

发明人： John Chapples ,  John Anthony Tilloston ,  Ian McLeod ,  Martin Williamson

IPC分类号： G01N27/407

CPC分类号： G01N27/404

摘要： An electrochemical oxygen sensor includes a micro-porous plastic membrane supported on a sealing disk and located between a gas inflow port and the sensor's electrolyte. The membrane and disk minimize thermal shock effects due to using the sensor at a first location, at a first temperature, and then moving it to a second location at a different temperature.

摘要翻译： 电化学氧传感器包括支撑在密封盘上并位于气体流入端口和传感器电解质之间的微孔塑料膜。 膜和盘片使得在第一温度下使用传感器的热冲击效应最小化，然后将其移动到不同温度的第二位置。

公开(公告)号：US08252158B2

公开(公告)日：2012-08-28

申请号：US11877331

申请日：2007-10-23

申请人： John Chapples ,  John Anthony Tillotson ,  Ian McLeod ,  Martin Williamson

发明人： John Chapples ,  John Anthony Tillotson ,  Ian McLeod ,  Martin Williamson

IPC分类号： G01N27/413

CPC分类号： G01N27/404

摘要： An electrochemical oxygen sensor includes a micro-porous plastic membrane supported on a sealing disk and located between a gas inflow port and the sensor's electrolyte. The membrane and disk minimize thermal shock effects due to using the sensor at a first location, at a first temperature, and then moving it to a second location at a different temperature.

摘要翻译： 电化学氧传感器包括支撑在密封盘上并位于气体流入端口和传感器电解质之间的微孔塑料膜。 膜和盘片使得在第一温度下使用传感器的热冲击效应最小化，然后将其移动到不同温度的第二位置。

公开(公告)号：US20120061929A1

公开(公告)日：2012-03-15

申请号：US13289910

申请日：2011-11-04

申请人： Ian McLeod ,  Pat McLeod

发明人： Ian McLeod ,  Pat McLeod

IPC分类号： A63C5/00

CPC分类号： A63C5/0417 ,  A63C5/03

摘要： Some embodiments are directed to a board for riding on a snow surface, comprising a base having a first snow engaging element, a second snow engaging element, and a third snow engaging element positioned on a bottom surface of the base. The first snow engaging element can be positioned beneath a user's front foot during operation of the board and positioned entirely on a forward half of the base. The second and third snow engaging elements can be positioned such that a fore portion of each is positioned beneath a user's front foot during operation of the board and extends toward the rear portion of the board at least to the user's rear foot. In some embodiments, the snow engaging elements can be protrusions, depressions, or otherwise, and can be removably supported by the base.

摘要翻译： 一些实施例涉及用于骑在雪地表面上的板，包括具有第一雪接合元件，第二雪接合元件的底座和位于底座的底表面上的第三雪接合元件。 在板的操作期间，第一个雪接合元件可以位于使用者的前脚下方，并且完全位于基座的前半部上。 第二和第三雪接合元件可以被定位成使得在板的操作期间每个的前部位于使用者的前脚下方，并且至少延伸到使用者的后脚的板的后部。 在一些实施例中，雪接合元件可以是突起，凹陷或其它方式，并且可以由底座可拆卸地支撑。

公开(公告)号：US20110204596A1

公开(公告)日：2011-08-25

申请号：US12852293

申请日：2010-08-06

申请人： Ian McLeod ,  Pat McLeod ,  Bruce Duncan

发明人： Ian McLeod ,  Pat McLeod ,  Bruce Duncan

IPC分类号： A63C5/04

CPC分类号： A63C5/0417 ,  A63C5/03

摘要： Some embodiments are directed to a board for riding on a snow surface, comprising a base having a first snow engaging element, a second snow engaging element, and a third snow engaging element positioned on a bottom surface of the base. The first snow engaging element can be positioned beneath a user's front foot during operation of the board and positioned entirely on a forward half of the base. The second and third snow engaging elements can be positioned such that a fore portion of each is positioned beneath a user's front foot during operation of the board and extends toward the rear portion of the board at least to the user's rear foot. In some embodiments, the snow engaging elements can be protrusions, depressions, or otherwise, and can be removably supported by the base.

摘要翻译： 一些实施例涉及用于骑在雪地表面上的板，包括具有第一雪接合元件，第二雪接合元件的底座和位于底座的底表面上的第三雪接合元件。 在板的操作期间，第一个雪接合元件可以位于使用者的前脚下方，并且完全位于基座的前半部上。 第二和第三雪接合元件可以被定位成使得在板的操作期间每个的前部位于使用者的前脚下方，并且至少延伸到使用者的后脚的板的后部。 在一些实施例中，雪接合元件可以是突起，凹陷或其它方式，并且可以由底座可拆卸地支撑。

公开(公告)号：US07317086B2

公开(公告)日：2008-01-08

申请号：US10302279

申请日：2002-11-22

申请人： Michael C. Dean ,  Heidi Eve Hahn ,  Carol Wicking ,  Jeffrey Christiansen ,  Peter G. Zaphiropoulos ,  Mae R. Gailani ,  Susan M. Shanley ,  Abirami Chidambaram ,  Igor Vorechovsky ,  Erika Holmberg-Lindstrom ,  Anne B. Unden ,  Susan A. Gilles ,  Kylie Negus ,  Ian McLeod Smyth ,  Carol L. Pressman ,  David J. Leffell ,  Bernard Gerrard ,  Alisa M. Goldstein ,  Brandon Wainwright ,  Rune C. M. Toftgard ,  Georgia Chenevix-Trench ,  Allen E. Bale

发明人： Michael C. Dean ,  Heidi Eve Hahn ,  Carol Wicking ,  Jeffrey Christiansen ,  Peter G. Zaphiropoulos ,  Mae R. Gailani ,  Susan M. Shanley ,  Abirami Chidambaram ,  Igor Vorechovsky ,  Erika Holmberg-Lindstrom ,  Anne B. Unden ,  Susan A. Gilles ,  Kylie Negus ,  Ian McLeod Smyth ,  Carol L. Pressman ,  David J. Leffell ,  Bernard Gerrard ,  Alisa M. Goldstein ,  Brandon Wainwright ,  Rune C. M. Toftgard ,  Georgia Chenevix-Trench ,  Allen E. Bale

IPC分类号： C07K14/47 ,  C12N15/12 ,  G01N33/574

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/4703 ,  Y10S530/828 ,  Y10S530/842

摘要： This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.

摘要翻译： 本发明提供了一种肿瘤抑制基因失活，其是痣基底细胞癌综合征和各种散发性基底细胞癌的致病因素。 NBCCS基因是果蝇补丁（ptc）基因的同系物。

公开(公告)号：US20120285828A1

公开(公告)日：2012-11-15

申请号：US13529568

申请日：2012-06-21

申请人： John Chapples ,  John Anthony Tillotson ,  Ian McLeod ,  Martin Williamson

发明人： John Chapples ,  John Anthony Tillotson ,  Ian McLeod ,  Martin Williamson

IPC分类号： G01N27/403

CPC分类号： G01N27/404

摘要： An electrochemical oxygen sensor includes a micro-porous plastic membrane supported on a sealing disk and located between a gas inflow port and the sensor's electrolyte. The membrane and disk minimize thermal shock effects due to using the sensor at a first location, at a first temperature, and then moving it to a second location at a different temperature.

摘要翻译： 电化学氧传感器包括支撑在密封盘上并位于气体流入端口和传感器电解质之间的微孔塑料膜。 膜和盘片使得在第一温度下使用传感器的热冲击效应最小化，然后将其移动到不同温度的第二位置。