公开(公告)号：US20070128136A1

公开(公告)日：2007-06-07

申请号：US10596211

申请日：2004-10-19

申请人： Ick-Dong Yoo ,  Won-Gon Kim ,  In-Ja Ryoo ,  Jong-Pyung Kim ,  Sangku Lee ,  Seo-Hyoung Park ,  Dong-Seok Kim ,  Kyoung-Chan Park

发明人： Ick-Dong Yoo ,  Won-Gon Kim ,  In-Ja Ryoo ,  Jong-Pyung Kim ,  Sangku Lee ,  Seo-Hyoung Park ,  Dong-Seok Kim ,  Kyoung-Chan Park

IPC分类号： A61K8/35 ,  A61K31/12

CPC分类号： C12P7/38 ,  A61K8/35 ,  A61K31/122 ,  A61K2800/782 ,  A61Q19/02

摘要： The present invention relates to a melanin biosynthesis inhibitor containing terrein compound as an effective ingredient. The terrein compound can be easily separated from Penicillium sp KCTC 26245, a fungal strain inhabited in domestic soil. It does not directly inhibit tyrosinase but inhibits the expression of MITF (microphthalmia-associated transcription factor) by activating ERK (extracellular signal-regulated kinase) in melanin chromatocytes to give whitening effect. So, the melanin biosynthesis inhibiting effect of the compound is much greater than that of any other conventional inhibitors, and further the effect can be raised when the compound is used together with other inhibitors, owing to their different mechanisms. Thus, the compound of the present invention can be effectively used as a skin trouble treating agent, a skin whitening agent and a browning inhibitor.

摘要翻译： 本发明涉及含有土曲霉化合物作为有效成分的黑色素生物合成抑制剂。 土霉素化合物可以容易地从青霉菌KCTC 26245（一种居住在土壤中的真菌菌株）分离出来。 它不直接抑制酪氨酸酶，而是通过激活黑色素染色质细胞中的ERK（细胞外信号调节激酶）来抑制MITF（小耳垢相关转录因子）的表达，从而产生美白效果。 因此，化合物的黑色素生物合成抑制作用比任何其它常规抑制剂的黑色素生物合成抑制作用要大得多，而且由于其不同的机制，当化合物与其它抑制剂一起使用时，可以提高其效果。 因此，本发明的化合物可以有效地用作皮肤麻烦处理剂，皮肤增白剂和褐变抑制剂。

公开(公告)号：US06943007B2

公开(公告)日：2005-09-13

申请号：US09846634

申请日：2001-05-01

申请人： Ick-Dong Yoo ,  Soo-Muk Cho ,  Byeung-Wook Park ,  Jae-Kuk Yoo ,  Nam-Doo Hong ,  Hwan-Mook Kim ,  Sang-Bae Han ,  Chang-Woo Lee

发明人： Ick-Dong Yoo ,  Soo-Muk Cho ,  Byeung-Wook Park ,  Jae-Kuk Yoo ,  Nam-Doo Hong ,  Hwan-Mook Kim ,  Sang-Bae Han ,  Chang-Woo Lee

IPC分类号： A01H15/00 ,  A61K31/00 ,  C12N1/14 ,  A01N63/04 ,  C12P1/02 ,  C12P19/04

CPC分类号： A01H15/00 ,  Y10S435/911

摘要： There is disclosed novel Phellinus linteus Yoo. This mushroom is identified as novel as analyzed by restriction fragment length polymorphism and by microbiological features. A polysaccharide substance isolated from the fruiting bodies or mycelia the strain and other Phellinus spp. has an anticancer activity by inciting the cytotoxicity of T-cells and the antibody forming potency of B-cells. Also, the polysaccharide substance shows a potent activity against cancer metastasis. The polysaccharide substance, which can stimulate the immunity of the body, may be effective in the prophylaxis and treatment of immune-related diseases, such as cancers and AIDS, and in the study on the basic mechanism of the diseases.

摘要翻译： 有披露小说的桑黄柚。 这种蘑菇被鉴定为新颖的，通过限制性片段长度多态性和微生物特征分析。 从子实体或菌丝体中分离出的多糖物质菌株和其他桑黄属。 通过诱导T细胞的细胞毒性和B细胞的抗体形成效力具有抗癌活性。 此外，多糖物质显示出对癌症转移的有效活性。 可以刺激身体免疫力的多糖物质可以有效预防和治疗免疫相关疾病如癌症和艾滋病，以及对疾病基本机制的研究。