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    Terrein compound having melanin biosynthesis inhibitors and its preparation
    1.
    发明申请
    Terrein compound having melanin biosynthesis inhibitors and its preparation 审中-公开
    具有黑色素生物合成抑制剂的土鳖素化合物及其制备

    公开(公告)号：US20070128136A1

    公开(公告)日：2007-06-07

    申请号：US10596211

    申请日：2004-10-19

    申请人： Ick-Dong Yoo ,  Won-Gon Kim ,  In-Ja Ryoo ,  Jong-Pyung Kim ,  Sangku Lee ,  Seo-Hyoung Park ,  Dong-Seok Kim ,  Kyoung-Chan Park

    发明人： Ick-Dong Yoo ,  Won-Gon Kim ,  In-Ja Ryoo ,  Jong-Pyung Kim ,  Sangku Lee ,  Seo-Hyoung Park ,  Dong-Seok Kim ,  Kyoung-Chan Park

    IPC分类号： A61K8/35 ,  A61K31/12

    CPC分类号： C12P7/38 ,  A61K8/35 ,  A61K31/122 ,  A61K2800/782 ,  A61Q19/02

    摘要： The present invention relates to a melanin biosynthesis inhibitor containing terrein compound as an effective ingredient. The terrein compound can be easily separated from Penicillium sp KCTC 26245, a fungal strain inhabited in domestic soil. It does not directly inhibit tyrosinase but inhibits the expression of MITF (microphthalmia-associated transcription factor) by activating ERK (extracellular signal-regulated kinase) in melanin chromatocytes to give whitening effect. So, the melanin biosynthesis inhibiting effect of the compound is much greater than that of any other conventional inhibitors, and further the effect can be raised when the compound is used together with other inhibitors, owing to their different mechanisms. Thus, the compound of the present invention can be effectively used as a skin trouble treating agent, a skin whitening agent and a browning inhibitor.

    摘要翻译： 本发明涉及含有土曲霉化合物作为有效成分的黑色素生物合成抑制剂。 土霉素化合物可以容易地从青霉菌KCTC 26245（一种居住在土壤中的真菌菌株）分离出来。 它不直接抑制酪氨酸酶，而是通过激活黑色素染色质细胞中的ERK（细胞外信号调节激酶）来抑制MITF（小耳垢相关转录因子）的表达，从而产生美白效果。 因此，化合物的黑色素生物合成抑制作用比任何其它常规抑制剂的黑色素生物合成抑制作用要大得多，而且由于其不同的机制，当化合物与其它抑制剂一起使用时，可以提高其效果。 因此，本发明的化合物可以有效地用作皮肤麻烦处理剂，皮肤增白剂和褐变抑制剂。

    collagenous matrix with improved porosity and tensile strength and preparation method therefore by using mechanical stimulation system
    3.
    发明申请
    collagenous matrix with improved porosity and tensile strength and preparation method therefore by using mechanical stimulation system 审中-公开
    胶原基质具有改善的孔隙度和拉伸强度，因此通过使用机械刺激系统制备方法

    公开(公告)号：US20090209020A1

    公开(公告)日：2009-08-20

    申请号：US12084570

    申请日：2006-11-06

    申请人： Kyoung-Chan Park ,  Sun-Bang Kwon ,  Hye-Ryung Choi

    发明人： Kyoung-Chan Park ,  Sun-Bang Kwon ,  Hye-Ryung Choi

    IPC分类号： C12N11/04

    CPC分类号： C12N5/0698 ,  C12M25/14 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2533/54

    摘要： The present invention relates to a method of preparing a collagen matrix with increased porosity and tensile strength by using mechanical stimulation system. More specifically, in the present invention, the cell-populated gel is being cultured under the condition that the physical forces is loaded for causing the matrix to move periodically and discontinuously. Resulting collagen matrix can be used for preparing an artificial skin or organs. Furthermore, this collagen matrix can be used as fillers for esthetic or therapeutic purposes.

    摘要翻译： 本发明涉及通过使用机械刺激系统制备具有增加的孔隙率和拉伸强度的胶原基质的方法。 更具体地说，在本发明中，在负载物理力使基质周期性地不连续地移动的条件下培养细胞的凝胶。 所得的胶原基质可用于制备人造皮肤或器官。 此外，该胶原基质可用作美学或治疗目的的填料。