摘要:
The present invention provides novel bridged beta-carboline compounds that are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 and analogues thereof and pharmaceutical compositions and kits that include these compounds.
摘要:
A letter whose letter card consists of one or more plates of hard-paste china bearing one or more messages in the form of images, handwritten notes, proverbs, verses or the like. The envelope for the letter card consists of relatively stiff and shock-absorbent material, such as corrugated cardboard. Prior to introduction into the envelope, the letter card is placed into a recess formed in one side of an insert which snugly fits into the envelope and is also made of corrugated cardboard. The letter card can be assembled of two plates which are pivotally connected to each other by one or more flexible strips so that they can pivot relative to each other between first positions of full overlap and second positions in which they are located in mutually inclined planes. The letter card can be placed on a table top, suspended on a wall, framed or otherwise set up for more or less permanent exhibition in a home, office, dormitory, military barracks or the like. The plate or plates of the letter card can have an outline other than a rectangular outline. The rear side of each plate can be bonded to a sheet of paper or cardboard serving to receive handwritten and/or printed messages.
摘要:
A method is described for inhibiting mitogen activated protein kinase-activated protein kinase-2 in a subject in need of such inhibition, where the method involves administering to the subject a beta-carboline MK-2 inhibiting compound, or a pharmaceutically acceptable salt thereof.
摘要:
Compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNFα, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.
摘要:
A letter whose letter card consists of one or more plates of hard-paste china bearing one or more messages in the form of images, handwritten notes, proverbs, verses or the like. The envelope for the letter card consists of relatively stiff and shock-absorbent material, such as corrugated cardboard. Prior to introduction into the envelope, the letter card is placed into a recess formed in one side of an insert which snugly fits into the envelope and is also made of corrugated cardboard or a like shock-absorbent material to reduce the likelihood of chipping, breakage and/or other damage to the letter card during mailing or other mode of shipment to the recipient(s). The letter card can be assembled of two plates which are pivotally connected to each other by one or more flexible strips so that they can pivot relative to each other between first positions of full overlap preparatory to introduction into the envelope and second positions in which they are located in mutually inclined planes. The letter card can be placed on a table top, suspended on a wall, framed or otherwise set up for more or less permanent exhibition in a home, office, dormitory, military barracks or the like.
摘要:
A foldable letter that can be mailed. The latter encompasses a cut-out paper sheet, one surface of which is intended to receive communications or messages, and the other side of which is intended to receive postal indications, i.e., an address. This letter solves the double problem of finding a form that encourages the writing of letters in the face of the progression of electronic communication equipment and, on the other hand, of enabling easy opening of a folded and sealed letter without tearing it. The proposed solution relates to an appropriate carrier for handwritten communications, and a closure technique offering to the receiver an acceptable letter in its original size. The letter has a square basic shape and includes a rectangular field, the long sides of which are parallel, but not symmetrical, to one of the diagonals of the square. The four triangular closure flaps of the sheet are folded back to one face or side of the letter, and the edges of the flaps completely overlap and stick to one another. The side of the sheet that receives the communication is preferably lined on its entire surface, and parallel to two of the edges. Furthermore, the edges provided for the closure are provided on one side with detachable strips which, after the letter is opened, remain fixed to the nonwritten side. For this purpose, these strips are provided with a perforation.