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    BENZIMIDAZOLONE DERIVATIVES
    1.
    发明申请
    BENZIMIDAZOLONE DERIVATIVES 审中-公开

    公开(公告)号：US20090298811A1

    公开(公告)日：2009-12-03

    申请号：US12440646

    申请日：2007-09-03

    申请人： Kazuo Ando ,  Ingrid Price Buchler ,  Shridhar Gajanan Hedge ,  Makoto Kawai ,  Tsutomu Masuda ,  Hirofumi Omura

    发明人： Kazuo Ando ,  Ingrid Price Buchler ,  Shridhar Gajanan Hedge ,  Makoto Kawai ,  Tsutomu Masuda ,  Hirofumi Omura

    IPC分类号： A61K31/55 ,  A61K31/5377 ,  A61K31/4965 ,  A61K31/437 ,  A61K31/4245 ,  A61K31/4184 ,  C07D405/14 ,  C07D413/06 ,  C07D403/08 ,  C07D471/04 ,  C07D413/12 ,  C07D235/24

    CPC分类号： C07D413/06 ,  A61K31/16 ,  C07D235/26 ,  C07D401/06 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04

    摘要： This invention relates to compounds and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a mammal in need of such treatment a therapeutically effective amount of the compound of formula (I) or pharmaceutically acceptable salts thereof, wherein: A, B, R1, R2 and R3 are each as described herein. These compounds are useful in the treatment of a condition mediated by CB2 receptor binding activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic low back pain, visceral pain, acute cerebral ischemia, pain, chronic pain, acute pain, post herpetic neuralgia, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritic pain, osteoarthritic pain, back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, spasticity, epilepsy, Tourette's syndrome, Parkinson's disease, neuroprotection, anxiety, cough, broncho constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, cachexia, nausea, emesis, chemotherapy-induced emesis, rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, seasonal allergic rhinitis, gastroesophageal reflux disease (GERD), constipation, diarrhea, functional gastrointestinal disorder, cutaneous T cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, cerebral stroke, vasodialation, hypertension, vasculitis, myocardial infarction, cerebral ischemia, reversible airway obstruction, adult respiratory disease syndrome, chronic obstructive pulmonary disease (COPD), cryptogenic fibrosing alveolitis and bronchitis.