公开(公告)号：US07112569B2

公开(公告)日：2006-09-26

申请号：US10884729

申请日：2004-07-02

申请人： Sangmee Ahn Jo ,  Inho Jo ,  Ho Jeong Kwon ,  Chang Jin Kim ,  Jeong Eun Park

发明人： Sangmee Ahn Jo ,  Inho Jo ,  Ho Jeong Kwon ,  Chang Jin Kim ,  Jeong Eun Park

IPC分类号： A61K38/00

CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/4711

摘要： The present invention relates to a novel protein inhibiting β amyloid aggregation and a strain producing the protein, more precisely, to a novel protein inhibiting β amyloid aggregation, a gene coding the protein, a Streptomyces sp. strain producing the protein and a therapeutic agent for neurodegenerative disorders containing the protein as an effective ingredient. The therapeutic agent of the present invention containing the protein inhibiting β amyloid aggregation as an effective ingredient can be effectively used for the prevention and the treatment of neurodegenerative disorders like Alzheimer's disease.

摘要翻译： 本发明涉及抑制β-淀粉样蛋白的新型蛋白质聚集和产生蛋白质的菌株，更确切地说，涉及一种抑制β-淀粉样蛋白聚集的新蛋白质，一种编码该蛋白质的基因，一种链霉菌属（Streptomyces sp。）。 产生蛋白质的菌株和含有蛋白质作为有效成分的神经变性疾病的治疗剂。 含有蛋白质抑制β淀粉样蛋白聚集作为有效成分的本发明治疗剂可有效地用于预防和治疗神经变性疾病如阿尔茨海默氏病。

公开(公告)号：US20050009749A1

公开(公告)日：2005-01-13

申请号：US10884729

申请日：2004-07-02

申请人： Sangmee Ahn Jo ,  Inho Jo ,  Ho Kwon ,  Chang Kim ,  Jeong Park

发明人： Sangmee Ahn Jo ,  Inho Jo ,  Ho Kwon ,  Chang Kim ,  Jeong Park

IPC分类号： C07K14/36 ,  A61K38/00 ,  C07H21/04 ,  C07K14/47 ,  A61K38/16

CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/4711

摘要： The present invention relates to a novel protein inhibiting β amyloid aggregation and a strain producing the protein, more precisely, to a novel protein inhibiting β amyloid aggregation, a gene coding the protein, a Streptomyces sp. strain producing the protein and a therapeutic agent for neurodegenerative disorders containing the protein as an effective ingredient. The therapeutic agent of the present invention containing the protein inhibiting β amyloid aggregation as an effective ingredient can be effectively used for the prevention and the treatment of neurodegenerative disorders like Alzheimer's disease.

摘要翻译： 本发明涉及抑制β-淀粉样蛋白的新型蛋白质聚集和产生蛋白质的菌株，更确切地说，涉及一种抑制β-淀粉样蛋白聚集的新蛋白质，一种编码该蛋白质的基因，一种链霉菌属（Streptomyces sp。）。 产生蛋白质的菌株和含有蛋白质作为有效成分的神经变性疾病的治疗剂。 含有蛋白质抑制β淀粉样蛋白聚集作为有效成分的本发明治疗剂可有效地用于预防和治疗神经变性疾病如阿尔茨海默氏病。