公开(公告)号：US20120184739A1

公开(公告)日：2012-07-19

申请号：US13062236

申请日：2008-09-05

申请人： Dragos Vizititu ,  Ioana Simion ,  Jean Eric Lacoste

发明人： Dragos Vizititu ,  Ioana Simion ,  Jean Eric Lacoste

IPC分类号： C07D411/04

CPC分类号： C07D327/04

摘要： Single enantionmers of compounds of formula (B), in either the cis or trans configuration, wherein R1 and R2 are as defined herein, can be separated from enantiomeric mixtures thereof by reacting the compound with an acid to produce a conglomerate salt that has the following characteristics: the IR spectrum of the salt of the racemic compound, a 1:1 mixture of (−) and (+) crystals, is identical to that of the each of the single enantiomer, and the salt of the racemic compound has a melting point lower that that of either single enantiomer. The conglomerate salt is then separated by preferential crystallization.

摘要翻译： 式（B）化合物的单一对映体，其顺式或反式构型，其中R 1和R 2如本文所定义，可以通过使该化合物与酸反应，从而与其对映异构体混合物分离，从而产生具有下列化合物的砾岩盐 特征：外消旋化合物的盐，（ - ）和（+）晶体的1:1混合物的IR光谱与单一对映异构体的相同，外消旋化合物的盐具有熔融 低于单一对映异构体。 然后通过优先结晶分离砾岩盐。

公开(公告)号：US20060199786A1

公开(公告)日：2006-09-07

申请号：US11073020

申请日：2005-03-07

申请人： Alex Cimpoia ,  Dan Simion ,  Ioana Simion

发明人： Alex Cimpoia ,  Dan Simion ,  Ioana Simion

IPC分类号： A61K31/513 ,  A61K31/675 ,  C07D409/02 ,  C07F9/6512

CPC分类号： C07D411/04 ,  C07F9/65586

摘要： There is provided a method for resolving a compound of formula III, in the cis configuration: There is also provided a process for producing optically active compound of formula I or II: wherein: R1, R2, R3 are as defined herein, the method and process involving the production, recovery and conversion of diastereomeric salts.

摘要翻译： 提供了以顺式构型分解式III化合物的方法：还提供了制备式I或II的光学活性化合物的方法：其中：R 1，R SUB R 2，R 3，R 3和R 3如本文所定义，涉及非对映异构体盐的生产，回收和转化的方法和方法。