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公开(公告)号：US20240131361A1
公开(公告)日：2024-04-25
申请号：US18051970
申请日：2022-11-02
发明人： Rudi LABARBE , Lucian HOTOIU , Arnaud PIN
CPC分类号： A61N5/1043 , G21K1/10 , A61N5/1045 , A61N2005/1087 , A61N2005/1095
摘要： The present invention concerns a method for designing a ridge filter for a charged particle accelerator, for depositing with beams of accelerated particles (100.i) specific doses (Dij) into specific locations within a treatment volume (V) of tissue comprising tumoral cells (3t) by single layer pencil beam scanning (PBS), according to a predefined treatment plan (TP), the method comprising the following steps,
Defining an array of spots (Si) defining the bases of cylindrical subvolumes (Vi) defining the treatment volume (V); the subvolumes (Vi) are divided into N cells (Cij).
The ridge filter is designed comprising the same number of energy degrading units (11.i) as there are spots (Si). Each energy degrading unit (11.i) is formed by N cylindrical degrading subunits (11.ij) of lengths (Lij) and area (Aij).
The lengths (Lij) of each degrading subunit (11.ij) are calculated as Lij=Wij/Wu, and Wij=W0−dij, wherein
Wij is the desired subunit water equivalent thickness (Wij),
Wu is the subunit water equivalent thickness per unit length (Wu),
W0 is the maximum beam range and
dij is the desired position of the Bragg peak along the irradiation axis (X).
The area (Aij) of each degrading subunit (11.ij) is obtained by determining the area boundary (Aij) of the integral at the numerator satisfying the following Equation (1).
ω
ij
∑
j
ω
ij
=
∫
∫
Aij
F
(
y
,
z
)
·
dy
·
dz
∫
∫
Abi
F
(
y
,
z
)
·
dy
·
dz
,
wherein
(
1
)
ωij/Σjωij is the normalized beam weight,
F(y,z) is the fluence of the beam,
Abi is the base area (Abi) of the degrading unit (11.i).-
公开(公告)号：US20220347494A1
公开(公告)日：2022-11-03
申请号：US17773238
申请日：2020-10-29
摘要： A radiotherapy apparatus for the delivery of an energetic beam to a target tissue in a treatment zone, including: a rotatable gantry for rotating the end of a beam delivery system about a circle centered on an isocentre and normal to an axis of rotation Z1 of the gantry, the path between the end of the beam delivery system and the isocentre defining a central beam axis Z2 at every rotation angle of the gantry about the axis of rotation Z1; an imaging ring having a central bore and an imaging system for acquiring images of a patient in an imaging zone of the imaging system, wherein the imaging ring is located in the radiotherapy apparatus such that its imaging zone intersects the axis of rotation Z1 of the gantry, and wherein the imaging ring is mechanically coupled to the rotatable gantry through a mechanical structure.
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公开(公告)号：US20220163464A1
公开(公告)日：2022-05-26
申请号：US17533504
申请日：2021-11-23
发明人： Peter BAKER , Frédéric Stichelbaut , Christophe Malice , Dominique Vincent , Candice Nagel , Frédéric Dessy
IPC分类号： G01N23/083 , G01N23/10
摘要： The present invention concerns an apparatus for irradiating goods with X-rays, comprising a first source of X-rays configured for emitting X-rays along a first irradiation volume centered on a longitudinal axis (X), and a conveyor configured for driving goods such as to expose a first portion of the goods through the first irradiation volume,
wherein, the conveyor is configured for driving the target products through the irradiation volume along a vertical axis (Z).-
公开(公告)号：US11160159B2
公开(公告)日：2021-10-26
申请号：US17193997
申请日：2021-03-05
摘要： A synchrocyclotron for extracting charged particles accelerated to an extraction energy includes a magnetic unit comprising N valley sectors and N hill sectors, and configured for creating z-component of a main magnetic characterized by a radial tune of the successive orbits. The synchrocyclotron includes a first instability coil unit and a second instability coil unit configured for creating a field bump of amplitude increasing radially. The amplitude of the field bump may be varied to reach the value of the offset amplitude at the average instability onset radius. The offset amplitude may be the minimal amplitude of the field bump at the average instability onset radius required for sufficiently offsetting the center of the orbit of average instability onset radius to generate a resonance instability to extract the beam of charged particle at the average instability onset radius.
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公开(公告)号：US11058897B2
公开(公告)日：2021-07-13
申请号：US16606121
申请日：2018-04-19
发明人： Raphael Van Roermund
摘要： An electron accelerator including a resonant cavity, an electron source, an RF system, and at least one magnet unit is provided. The resonant cavity further includes a hollow closed conductor and the electron source is configured to radially inject a beam of electrons into the cavity. The RF system is configured to generate an electric field to accelerate the electrons along radial trajectories. The at least one magnet unit further-includes a deflecting magnet configured to generate a magnetic field that deflects an electron beam emerging out of the resonant cavity along a first radial trajectory and redirects the electron beam into the resonant cavity along a second radial trajectory. The resonant cavity further includes a first half shell, a second half shell, and a central ring element.
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公开(公告)号：US10919019B2
公开(公告)日：2021-02-16
申请号：US15729620
申请日：2017-10-10
发明人： Michel Guyette , Jozef Comor
摘要： The present disclosure relates to an apparatus for the synthesis of chemical compounds, e.g., radiopharmaceutical compounds. In one implementation, the apparatus may include a synthesis module and a loading module configured to receive multiple chemical cassettes having reagents and a transfer mechanism. The apparatus may further include a shifter configured to move the cassettes from a location on the loading module to a location connected to the synthesis module on an interface configured to connect to the cassette.
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公开(公告)号：US20200029421A1
公开(公告)日：2020-01-23
申请号：US16227698
申请日：2018-12-20
发明人： Sébastien DE NEUTER , Jean-Michel GEETS , Benoit NACTERGAL , Vincent NUTTENS , Jarno VAN DE WALLE
IPC分类号： H05H13/00
摘要： A cyclotron for accelerating a beam of charged particles and extracting the beam. The cyclotron includes a vacuum chamber; a target support element sealed and coupled to the vacuum chamber and including a tubular channel leading to a target; first energy specific extraction kit including a first stripper assembly with a stripper located at a first stripping position for stripping charged particles at a first energy and a second energy specific extraction kit for driving modified charged particles of second energy along a second extraction path towards a target holder, wherein the energy specific extraction kit includes: a second stripper assembly with a stripper located at a second stripping position for stripping charged particles at a second energy and an insert for modifying an orientation of the tubular channel to match the second extraction path such that the modified charged particles of second energy intercept the target holder.
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公开(公告)号：US10304322B2
公开(公告)日：2019-05-28
申请号：US15008294
申请日：2016-01-27
发明人： Vincent Bossier , David Wikler , Frédéric Genin , Sofie Gillis , Christophe Bauvir , Henri Bourmorck , Geoffroy Herbin , Olivier Scalbert
摘要： An apparatus comprising a wireless communication device for enabling the remote control of a medical apparatus The apparatus includes a remote control enable device comprising a transmitter and one or more switches, actuatable by enable buttons. The buttons allow an operator to close the switch(es), causing the transmitter to send a status signal related to the status (open or closed) of the switch(es), to a receiver configured to communicate said status signal to a control unit. The control unit verifies the signal on a number of criteria. When all required criteria have been met, remote control of the medical apparatus is allowed. In an embodiment the remote control enable device is configured to maintain the power supply to a transmitting chip sufficiently long, upon opening a switch, so that a check can be performed on the correct functioning of the switch after the switch has been opened.
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公开(公告)号：US10271418B2
公开(公告)日：2019-04-23
申请号：US15805509
申请日：2017-11-07
摘要： An electron accelerator is provided. The electron accelerator comprises a resonant cavity comprising a hollow closed conductor, an electron source configured to inject a beam of electrons, and an RF system. The electron accelerator further comprises a magnet unit, comprising a deflecting magnet. The deflecting magnet is configured to generate a magnetic field in a deflecting chamber in fluid communication with the resonant cavity by a deflecting window. The magnetic field is configured to deflect an electron beam emerging out of the resonant cavity through the deflecting window along a first radial trajectory in the mid-plane (Pm) and to redirect the electron beam into the resonant cavity through the deflecting window towards the central axis along a second radial trajectory. The deflecting magnet is composed of first and second permanent magnets positioned on either side of the mid-plane (Pm).
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公开(公告)号：US10105119B2
公开(公告)日：2018-10-23
申请号：US15567879
申请日：2016-04-22
摘要： A phantom and method for quality assurance of a particle therapy apparatus used in the intensity modulated particle therapy (IMPT) mode is provided. The phantom comprises a frame structure having a first face and a second face that is parallel to the first face. The phantom further comprises one or more wedges, and a first and second block of material each having a first block face and a second block face parallel thereto. In addition, the phantom further includes an absolute dosimeter arranged at the first block face. A plurality of beads of high density material is located in the first or second block, and a 2D detector is arranged at the second face of the frame structure.
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