公开(公告)号：US20080096812A1

公开(公告)日：2008-04-24

申请号：US11666443

申请日：2005-10-27

申请人： Kouji Okamoto ,  Hiroshi Yamada ,  Iori Maeda

发明人： Kouji Okamoto ,  Hiroshi Yamada ,  Iori Maeda

IPC分类号： A61K38/39 ,  C07K14/78 ,  C07K1/14 ,  A61P9/10 ,  A61P7/02 ,  A23J1/00

CPC分类号： C07K14/78 ,  A61K38/00

摘要： A low-molecular-weight water-soluble elastin having a molecular weight of about 10,000 to 30,000 and a high-molecular-weight water-soluble elastin having a molecular weight of about 30,000 to 300,000 are provided, 79% to 84% of the constituent amino acids of the elastin comprising proline, glycine, alanine, and valine, 2% to 3% comprising aspartic acid and glutamic acid, 0.7% to 1.3% comprising lysine, histidine, and arginine, and 0.2% to 0.4% comprising desmosine and isodesmosine. The low-molecular-weight water-soluble elastin that is obtained may be used in a functional food or a medicine. Such a high-purity water-soluble elastin may be produced by obtaining pure insoluble elastin by subjecting animal body tissue to a collagen removal treatment and then fragmenting the insoluble elastin by means of a solubilizing liquid. It may be produced simply, merely by adjusting the concentration of an alkaline solution and the reaction time without recovering insoluble elastin from the animal body tissue.

摘要翻译： 提供分子量约为10,000至30,000的低分子量水溶性弹性蛋白和分子量为约30,000至300,000的高分子量水溶性弹性蛋白，79％至84％的成分 包含脯氨酸，甘氨酸，丙氨酸和缬氨酸的弹性蛋白的氨基酸，包含天冬氨酸和谷氨酸的2％至3％，包含赖氨酸，组氨酸和精氨酸的0.7％至1.3％的氨基酸，以及包含去肌氨酸和异丝氨酸的0.2％至0.4％ 。 获得的低分子量水溶性弹性蛋白可以用于功能性食品或药物中。 这样的高纯度水溶性弹性蛋白可以通过使动物体组织进行胶原去除处理，然后利用增溶液使不溶性弹性蛋白破碎而获得纯不溶性弹性蛋白来制造。 仅通过调节碱性溶液的浓度和反应时间就可以简单地制备，而不从动物体组织中回收不溶性弹性蛋白。

公开(公告)号：US07851441B2

公开(公告)日：2010-12-14

申请号：US11666443

申请日：2005-10-27

申请人： Kouji Okamoto ,  Hiroshi Yamada ,  Iori Maeda

发明人： Kouji Okamoto ,  Hiroshi Yamada ,  Iori Maeda

IPC分类号： A61K38/39 ,  C07K14/78 ,  C07K1/14

CPC分类号： C07K14/78 ,  A61K38/00

摘要： A low-molecular-weight water-soluble elastin having a molecular weight of about 10,000 to 30,000 and a high-molecular-weight water-soluble elastin having a molecular weight of about 30,000 to 300,000 are provided, 79% to 84% of the constituent amino acids of the elastin comprising proline, glycine, alanine, and valine, 2% to 3% comprising aspartic acid and glutamic acid, 0.7% to 1.3% comprising lysine, histidine, and arginine, and 0.2% to 0.4% comprising desmosine and isodesmosine. The low-molecular-weight water-soluble elastin that is obtained may be used in a functional food or a medicine. Such a high-purity water-soluble elastin may be produced by obtaining pure insoluble elastin by subjecting animal body tissue to a collagen removal treatment and then fragmenting the insoluble elastin by means of a solubilizing liquid. It may be produced simply, merely by adjusting the concentration of an alkaline solution and the reaction time without recovering insoluble elastin from the animal body tissue.

摘要翻译： 提供分子量约为10,000至30,000的低分子量水溶性弹性蛋白和分子量为约30,000至300,000的高分子量水溶性弹性蛋白，79％至84％的成分 包含脯氨酸，甘氨酸，丙氨酸和缬氨酸的弹性蛋白的氨基酸，包含天冬氨酸和谷氨酸的2％至3％，包含赖氨酸，组氨酸和精氨酸的0.7％至1.3％的氨基酸，以及包含去肌氨酸和异丝氨酸的0.2％至0.4％ 。 获得的低分子量水溶性弹性蛋白可以用于功能性食品或药物中。 这样的高纯度水溶性弹性蛋白可以通过使动物体组织进行胶原去除处理，然后利用增溶液使不溶性弹性蛋白破碎而获得纯不溶性弹性蛋白来制造。 仅通过调节碱性溶液的浓度和反应时间就可以简单地制备，而不从动物体组织中回收不溶性弹性蛋白。