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公开(公告)号:US07417118B2
公开(公告)日:2008-08-26
申请号:US10819352
申请日:2004-04-07
申请人: Toshiya Kai , Naohisa Katayama , Yuko Azuma , Junichi Yokoe , Yoshinori Kida , Ippei Hukutomi , Makoto Sato , Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Hiromi Sakai , Keitaro So
发明人: Toshiya Kai , Naohisa Katayama , Yuko Azuma , Junichi Yokoe , Yoshinori Kida , Ippei Hukutomi , Makoto Sato , Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Hiromi Sakai , Keitaro So
IPC分类号: C07K1/00
CPC分类号: A61K9/0026 , A01N1/02 , A01N1/0226 , A61K9/127 , A61K9/1271 , A61K38/42 , A61K47/6949 , B82Y5/00
摘要: A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a liposome-encapsulated hemoglobin in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.
摘要翻译: 一种含有人造氧载体的药物组合物,其具有高的氧气携带效率; 并具有所需的胶体渗透压,适当的晶体渗透压,pH和电解质平衡。 通过将至少一种选自由能够提供胶体渗透压的化合物,电解质,糖类,氨基酸,抗氧化剂,pH调节剂和等渗剂组成的组中选择的物质适当添加至 包括其中血红蛋白包封在脂质体中的脂质体包封的血红蛋白的制剂或包含卟啉 - 铁络合物和白蛋白的缀合物的制剂。