-
公开(公告)号：US07417118B2
公开(公告)日：2008-08-26
申请号：US10819352
申请日：2004-04-07
申请人： Toshiya Kai , Naohisa Katayama , Yuko Azuma , Junichi Yokoe , Yoshinori Kida , Ippei Hukutomi , Makoto Sato , Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Hiromi Sakai , Keitaro So
发明人： Toshiya Kai , Naohisa Katayama , Yuko Azuma , Junichi Yokoe , Yoshinori Kida , Ippei Hukutomi , Makoto Sato , Eishun Tsuchida , Shinji Takeoka , Teruyuki Komatsu , Hiromi Sakai , Keitaro So
IPC分类号： C07K1/00
CPC分类号： A61K9/0026 , A01N1/02 , A01N1/0226 , A61K9/127 , A61K9/1271 , A61K38/42 , A61K47/6949 , B82Y5/00
摘要： A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a liposome-encapsulated hemoglobin in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.
摘要翻译： 一种含有人造氧载体的药物组合物，其具有高的氧气携带效率; 并具有所需的胶体渗透压，适当的晶体渗透压，pH和电解质平衡。 通过将至少一种选自由能够提供胶体渗透压的化合物，电解质，糖类，氨基酸，抗氧化剂，pH调节剂和等渗剂组成的组中选择的物质适当添加至 包括其中血红蛋白包封在脂质体中的脂质体包封的血红蛋白的制剂或包含卟啉 - 铁络合物和白蛋白的缀合物的制剂。
-
公开(公告)号：US10195154B2
公开(公告)日：2019-02-05
申请号：US14125240
申请日：2012-06-08
IPC分类号： A61K9/28 , A61K9/00 , A61K9/20 , A61K9/50 , A61K31/00 , A61K31/196 , A61K31/4178
摘要： A method for easily producing orodispersible tablets that secure an eluting behavior of a principal agent in the digestive tract and mask unpleasant taste in the oral cavity is provided. Provided is a method for producing orodispersible tablets which includes mixing an additive to a principal agent to form principal agent particles as a granulation process, coating the principal agent particles with a coating agent to form coated particles as a coating process, and tableting the coated particles to form tablets as a tableting process, wherein the additive used in the granulation process contains a pH regulator, and the coating agent used in the coating process contains a pH-dependent polymer dissolving at pH 5 or more.
-
公开(公告)号：US20120294947A1
公开(公告)日：2012-11-22
申请号：US13519193
申请日：2010-12-28
IPC分类号： A61K9/14 , A61K31/437 , A61J3/10 , A61K31/4422 , A61P25/28 , A61K31/445 , A61K31/519
CPC分类号： A61K31/445 , A61K9/2077 , A61K9/2846 , A61K31/437 , A61K31/4422 , A61K31/519
摘要： Provided is an oral preparation that contains a medicinal component having an unpleasant taste and that has better qualities, for example, generation of an analogue can be reduced, better than oral preparations that are produced by conventional techniques and that contain a medicinal component having an unpleasant taste. This objective is achieved by adding a coating agent on the medicinal component and a disintegrator that has a carboxymethyl group.
摘要翻译： 本发明提供含有具有令人不快的味道并且具有更好质量的药物成分的口服制剂，例如可以减少类似物的产生，优于常规技术制备的含有不愉快的药物成分的口服制剂 味道。 该目的通过在药物成分上添加涂布剂和具有羧甲基的崩解剂来实现。
-
4.发明授权S-nitroso group-containing albumin, method for production, and anticancer agent 有权含有亚硝基的白蛋白，生产方法和抗癌剂公开(公告)号：US07893212B2
公开(公告)日：2011-02-22
申请号：US12201825
申请日：2008-08-29
申请人： Masaki Otagiri , Keisuke Nakajo , Naohisa Katayama , Toshiya Kai
发明人： Masaki Otagiri , Keisuke Nakajo , Naohisa Katayama , Toshiya Kai
IPC分类号： C07K16/00
CPC分类号： C07K14/76
摘要： The present invention provides an S-nitroso group-containing albumin, comprising an S-nitroso group introduced to at least one lysine in the amino acid sequence for albumin. The S-nitro group has been introduced into a lysine in the S-nitroso group-containing albumin of the invention to allow more S-nitroso groups to be included in the albumin, thus ensuring more potent inhibition of cancer cells in NO groups.
摘要翻译： 本发明提供含有S-亚硝基的白蛋白，其包含引入白蛋白氨基酸序列中的至少一个赖氨酸的S-亚硝基。 已将S-硝基引入本发明的含S-亚硝基基团的白蛋白中的赖氨酸中，以允许更多的S-亚硝基被包括在白蛋白中，从而确保NO组中对癌细胞的更有效的抑制。
-
公开(公告)号：US20070231395A1
公开(公告)日：2007-10-04
申请号：US10594613
申请日：2005-03-30
申请人： Toshiya Kai , Naohisa Katayama , Jun-ichi Yokoe , Makoto Sato
发明人： Toshiya Kai , Naohisa Katayama , Jun-ichi Yokoe , Makoto Sato
CPC分类号： A61K9/1611 , A61K9/0095 , A61K9/1682 , A61K31/191 , A61K31/7004 , A61K33/00 , A61K33/06 , A61K33/14 , A61K45/06 , A61M1/1654 , A61M1/287 , A61K2300/00
摘要： A solid pharmaceutical preparation for dialysis which does not contain any acetic acid and a production process thereof. The solid pharmaceutical preparation for dialysis contains two pharmaceutical preparations: a solid pharmaceutical preparation (A) composed of particles having an average particle size of about 100 μm to 1,500 μm and containing one or more electrolytes selected from sodium chloride, calcium chloride, magnesium chloride, and potassium chloride, and an organic acid other than acetic acid and/or a salt of the organic acid; and a solid pharmaceutical preparation (B) containing sodium bicarbonate.
摘要翻译： 不含任何乙酸的透析用固体药物制剂及其制造方法。 用于透析的固体药物制剂包含两种药物制剂：由平均粒径为约100〜1,500μm的粒子构成的固体药物制剂（A），含有一种或多种选自氯化钠，氯化钙，氯化镁， 和氯化钾，以及除乙酸以外的有机酸和/或有机酸的盐; 和含有碳酸氢钠的固体药物制剂（B）。
-
公开(公告)号：US07253259B2
公开(公告)日：2007-08-07
申请号：US11044265
申请日：2005-01-28
申请人： Masaki Otagiri , Yoshinori Kida , Naohisa Katayama , Toshiya Kai
发明人： Masaki Otagiri , Yoshinori Kida , Naohisa Katayama , Toshiya Kai
IPC分类号： C07K1/00
CPC分类号： C07K14/765
摘要： A protein produced by gene recombinant technology, including at least one domain selected from domains I, II, and III of serum albumin but having a different structure from that of native albumin; and a method of producing the protein. The protein has an enhanced functional activity or activities selected from among various functional activities or serum albumin including antibacterial activity, antioxidative effect, inflammation inhibitory effect, in vivo substance transporting action, and enzymatic activity.
摘要翻译： 由基因重组技术产生的蛋白质，其包括至少一个选自血清白蛋白结构域I，II和III的结构域，但与天然白蛋白结构不同的结构域; 和蛋白质的制造方法。 蛋白质具有增强的功能活性或选自各种功能活性或血清白蛋白的活性，包括抗菌活性，抗氧化作用，炎症抑制作用，体内物质运输作用和酶活性。
-
7.发明申请Injectable solution containing a shark-derived chondroitin sulfate iron colloid 审中-公开含有鲨鱼衍生的硫酸软骨素铁胶体的注射液公开(公告)号：US20050119223A1
公开(公告)日：2005-06-02
申请号：US11034259
申请日：2005-01-13
CPC分类号： A61K35/60 , A61K33/26 , A61K45/06 , A61K47/61 , A61K47/6905 , A61K2300/00
摘要： An injectable solution comprising a shark-derived chondroitin sulfate iron colloid, and a method for manufacturing an injectable solution comprising the step of adding an aqueous ferric salt solution and an aqueous alkali metal hydroxide solution to a shark-derived chondroitin sulfate solution, such that the resulting mixture has a pH value adjusted to any pH value within the range of from about 5.5 to about 7.5.
摘要翻译： 包含鲨鱼衍生的硫酸软骨素铁胶体的可注射溶液以及用于制备注射溶液的方法，包括将水溶液和碱金属氢氧化物水溶液加入鲨鱼衍生的硫酸软骨素溶液中， 所得混合物的pH值调节至约5.5至约7.5范围内的任何pH值。
-
公开(公告)号：US20140093567A1
公开(公告)日：2014-04-03
申请号：US14125240
申请日：2012-06-08
CPC分类号： A61K9/2893 , A61K9/0056 , A61K9/2004 , A61K9/2018 , A61K9/2081 , A61K9/5026 , A61K31/00 , A61K31/196 , A61K31/4178
摘要： A method for easily producing orodispersible tablets that secure an eluting behavior of a principal agent in the digestive tract and mask unpleasant taste in the oral cavity is provided. Provided is a method for producing orodispersible tablets which includes mixing an additive to a principal agent to form principal agent particles as a granulation process, coating the principal agent particles with a coating agent to form coated particles as a coating process, and tableting the coated particles to form tablets as a tableting process, wherein the additive used in the granulation process contains a pH regulator, and the coating agent used in the coating process contains a pH-dependent polymer dissolving at pH 5 or more.
摘要翻译： 提供了一种容易地生产可分散片剂的方法，其确保了消化道中主剂的洗脱行为并掩盖了口腔中的不愉快味道。 本发明提供一种生产可分散片剂的方法，其包括将添加剂与主剂混合以形成主剂颗粒作为造粒方法，用涂布剂涂覆主剂颗粒以形成涂布颗粒作为涂布方法，并将涂布的颗粒 形成片剂作为压片方法，其中在造粒方法中使用的添加剂含有pH调节剂，并且在涂布方法中使用的涂布剂含有溶于pH5以上的pH依赖性聚合物。
-
9.发明申请公开(公告)号：US20090099071A1
公开(公告)日：2009-04-16
申请号：US11873393
申请日：2007-10-16
申请人： Keisuke NAKAJOU , Naohisa KATAYAMA , Toshiya KAI , Masaki OTAGIRI
发明人： Keisuke NAKAJOU , Naohisa KATAYAMA , Toshiya KAI , Masaki OTAGIRI
CPC分类号： C07K14/765 , A61K38/00 , C07K14/76 , C12P21/005
摘要： Glycosylated albumin as a drug carrier for a DDS targeting the liver (particularly kupffer's cell) can be provided by mutating a DNA encoding albumin to encode a mutant albumin containing a partial amino acid sequence permitting glycosylation modification by eukaryotic cell, preferably a consensus sequence of N-linked sugar chain, introducing an expression vector containing the mutant DNA into a host eukaryotic cell, preferably a host cell permitting addition of a high-mannose type sugar chain, culturing the obtained transformant, and recovering a glycosylated albumin protein from the obtained culture.
摘要翻译： 作为靶向肝脏（特别是枯否氏细胞）的DDS的药物载体的糖基化白蛋白可以通过使编码白蛋白的DNA突变来编码含有允许真核细胞进行糖基化修饰的部分氨基酸序列的突变白蛋白，优选N 连接的糖链，将含有突变型DNA的表达载体导入宿主真核细胞，优选宿主细胞，允许加入高甘露糖型糖链，培养获得的转化体，并从获得的培养物中回收糖基化白蛋白。
-
10.发明申请ORALLY-DISINTEGRATING TABLET AND MANUFACTURING METHOD THEREOF 审中-公开ORALLY-DISINCATTATTING TABLET及其制造方法公开(公告)号：US20080254120A1
公开(公告)日：2008-10-16
申请号：US12099668
申请日：2008-04-08
申请人： Shiho Sakuragi , Jun-ichi Yokoe , Naohisa Katayama , Toshiya Kai
发明人： Shiho Sakuragi , Jun-ichi Yokoe , Naohisa Katayama , Toshiya Kai
IPC分类号： A61K9/26
CPC分类号： A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2095
摘要： An orally-disintegrating tablet comprises a principal agent, a sugar alcohol powder and a sugar alcohol granule, wherein the orally-disintegrating tablet has a hardness of 30 N or greater. According to the present invention, a smooth swallowing orally-disintegrating tablet, for which both the mechanical strength and the disintegration properties in the buccal cavity are favorable with using a normal tableting machine and without using special devices and the feeling on the tongue and taste are favorable, is provided.
摘要翻译： 口腔崩解片包含主剂，糖醇粉和糖醇颗粒，其中口腔崩解片的硬度为30N以上。 根据本发明，使用普通压片机，颊腔的机械强度和崩解性能均匀且不使用特殊的装置和舌头和口感的口感崩解片是平滑吞咽口腔崩解片， 有利的。
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.016 秒)
