公开(公告)号：US20080214569A1

公开(公告)日：2008-09-04

申请号：US11703401

申请日：2007-02-08

申请人： Zhengping Zhuang ,  Edward H. Oldfield ,  Deric M. Park ,  Irina Lubensky ,  Jie Li ,  John S. Kovach

发明人： Zhengping Zhuang ,  Edward H. Oldfield ,  Deric M. Park ,  Irina Lubensky ,  Jie Li ,  John S. Kovach

IPC分类号： A61K31/496 ,  C12Q1/02 ,  G01N33/50 ,  A61P35/00

CPC分类号： A61K31/496 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57484

摘要： This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N—CoR has suffered a recurrence of a tumor overexpressing N—CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.

摘要翻译： 本发明提供一种治疗患有过表达N-CoR的肿瘤患者的方法，其包括向患者施用有效治疗以下成分的量的单独或与类视色素受体配体，组蛋白脱乙酰酶配体或两者结合的磷酸酶配体 患者。 本发明还提供了抑制患有过量表达N-CoR的肿瘤患者的肿瘤生长的方法。 本发明还提供鉴定能够诱导过表达N-CoR的肿瘤细胞分化的化合物或化合物的混合物的方法。 本发明还提供了确定成功治疗患有过量表达N-CoR的肿瘤患者的可能性的方法。 本发明还提供了评估患者患有过度表达N-CoR的肿瘤的可能性的方法。 本发明还提供了一种评估先前患有和治疗过度表达N-CoR的肿瘤的患者遭受过度表达N-CoR的肿瘤复发的可能性的方法。 最后，本发明提供了用于多形性成胶质细胞瘤的类似方法。

公开(公告)号：US20090018142A9

公开(公告)日：2009-01-15

申请号：US11703401

申请日：2007-02-06

申请人： Zhengping Zhuang ,  Edward H. Oldfield ,  Deric M. Park ,  Irina Lubensky ,  Jie Li ,  John S. Kovach

发明人： Zhengping Zhuang ,  Edward H. Oldfield ,  Deric M. Park ,  Irina Lubensky ,  Jie Li ,  John S. Kovach

IPC分类号： A61K31/496 ,  C12Q1/02 ,  G01N33/50 ,  A61P35/00

CPC分类号： A61K31/496 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57484

摘要： This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N—CoR has suffered a recurrence of a tumor overexpressing N—CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.

摘要翻译： 本发明提供一种治疗患有过表达N-CoR的肿瘤患者的方法，其包括向患者施用有效治疗以下成分的量的单独或与类视色素受体配体，组蛋白脱乙酰酶配体或两者结合的磷酸酶配体 患者。 本发明还提供了抑制患有过量表达N-CoR的肿瘤患者的肿瘤生长的方法。 本发明还提供鉴定能够诱导过表达N-CoR的肿瘤细胞分化的化合物或化合物的混合物的方法。 本发明还提供了确定成功治疗患有过量表达N-CoR的肿瘤患者的可能性的方法。 本发明还提供了评估患者患有过度表达N-CoR的肿瘤的可能性的方法。 本发明还提供了一种评估先前患有和治疗过度表达N-CoR的肿瘤的患者遭受过度表达N-CoR的肿瘤复发的可能性的方法。 最后，本发明提供了用于多形性成胶质细胞瘤的类似方法。