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11 条记录 (耗时 0.022 秒)

    Isolation of cellular material under microscopic visualization
    2.
    发明授权
    Isolation of cellular material under microscopic visualization 失效
    在微观可视化下分离细胞材料

    公开(公告)号：US06204030B1

    公开(公告)日：2001-03-20

    申请号：US09388805

    申请日：1999-09-02

    申请人： Lance A. Liotta ,  Michael E. Buck ,  Rhonda Ann Weiss ,  Zhengping Zhuang ,  Robert F. Bonner

    发明人： Lance A. Liotta ,  Michael E. Buck ,  Rhonda Ann Weiss ,  Zhengping Zhuang ,  Robert F. Bonner

    IPC分类号： C12P1912

    CPC分类号： G02B21/32 ,  C12M33/02 ,  G01N1/04 ,  G01N1/08 ,  G01N1/2806 ,  G01N1/2813 ,  G01N1/286 ,  G01N1/31 ,  G01N15/1468 ,  G01N33/50 ,  G01N2001/028 ,  G01N2001/2833 ,  G01N2001/284 ,  G01N2035/00237 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375

    摘要： A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.

    摘要翻译： 一种显微切割的方法，其包括：使用显微镜形成组织样品的细胞的图像场，从细胞的图像区域鉴定感兴趣的细胞的至少一个区域，所述细胞的至少一个区域包括不同类型的细胞 而不是相邻的细胞区域，并且从组织样品中提取感兴趣的细胞的至少一个区域。 通过使组织样品与可以选择性活化的转移表面接触使得其区域粘附到待提取的感兴趣的细胞区域来实现提取。 转移表面包括可激发的粘合剂层，其向组织样品的选定区域提供化学或静电粘附。 转移表面被激活后，分离转移表面和组织样品。 在分离期间，感兴趣的细胞区域保持粘附到转移表面，并因此与组织样品分离。

    Use of phosphatases to treat tumors overexpressing N-CoR
    7.
    发明申请
    Use of phosphatases to treat tumors overexpressing N-CoR 审中-公开
    使用磷酸酶治疗过度表达N-CoR的肿瘤

    公开(公告)号：US20080214569A1

    公开(公告)日：2008-09-04

    申请号：US11703401

    申请日：2007-02-08

    申请人： Zhengping Zhuang ,  Edward H. Oldfield ,  Deric M. Park ,  Irina Lubensky ,  Jie Li ,  John S. Kovach

    发明人： Zhengping Zhuang ,  Edward H. Oldfield ,  Deric M. Park ,  Irina Lubensky ,  Jie Li ,  John S. Kovach

    IPC分类号： A61K31/496 ,  C12Q1/02 ,  G01N33/50 ,  A61P35/00

    CPC分类号： A61K31/496 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57484

    摘要： This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N—CoR has suffered a recurrence of a tumor overexpressing N—CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.

    摘要翻译： 本发明提供一种治疗患有过表达N-CoR的肿瘤患者的方法，其包括向患者施用有效治疗以下成分的量的单独或与类视色素受体配体，组蛋白脱乙酰酶配体或两者结合的磷酸酶配体 患者。 本发明还提供了抑制患有过量表达N-CoR的肿瘤患者的肿瘤生长的方法。 本发明还提供鉴定能够诱导过表达N-CoR的肿瘤细胞分化的化合物或化合物的混合物的方法。 本发明还提供了确定成功治疗患有过量表达N-CoR的肿瘤患者的可能性的方法。 本发明还提供了评估患者患有过度表达N-CoR的肿瘤的可能性的方法。 本发明还提供了一种评估先前患有和治疗过度表达N-CoR的肿瘤的患者遭受过度表达N-CoR的肿瘤复发的可能性的方法。 最后，本发明提供了用于多形性成胶质细胞瘤的类似方法。

    Isolation of cellular material under microscopic visualization
    8.
    发明授权
    Isolation of cellular material under microscopic visualization 失效
    在微观可视化下分离细胞材料

    公开(公告)号：US06569639B2

    公开(公告)日：2003-05-27

    申请号：US09765937

    申请日：2001-01-18

    申请人： Lance A. Liotta ,  Michael E. Buck ,  Rhonda Ann Weiss ,  Zhengping Zhuang ,  Robert F. Bonner

    发明人： Lance A. Liotta ,  Michael E. Buck ,  Rhonda Ann Weiss ,  Zhengping Zhuang ,  Robert F. Bonner

    IPC分类号： G01N130

    CPC分类号： G02B21/32 ,  C12M33/02 ,  G01N1/04 ,  G01N1/08 ,  G01N1/2806 ,  G01N1/2813 ,  G01N1/286 ,  G01N1/31 ,  G01N15/1468 ,  G01N33/50 ,  G01N2001/028 ,  G01N2001/2833 ,  G01N2001/284 ,  G01N2035/00237 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375

    摘要： A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.

    摘要翻译： 一种显微切割的方法，其包括：使用显微镜形成组织样品的细胞的图像场，从细胞的图像区域鉴定感兴趣的细胞的至少一个区域，所述细胞的至少一个区域包括不同类型的细胞 而不是相邻的细胞区域，并且从组织样品中提取感兴趣的细胞的至少一个区域。 通过使组织样品与可以选择性活化的转移表面接触使得其区域粘附到待提取的感兴趣的细胞区域来实现提取。 转移表面包括可激发的粘合剂层，其向组织样品的选定区域提供化学或静电粘附。 转移表面被激活后，分离转移表面和组织样品。 在分离期间，感兴趣的细胞区域保持粘附到转移表面，并因此与组织样品分离。