公开(公告)号：US4939142A

公开(公告)日：1990-07-03

申请号：US301944

申请日：1989-01-26

申请人： Zoltan Budai ,  Lujza Petocz ,  Tibor Mezei ,  Eniko Szirt nee Kiszelly ,  Maria Szecsey nee Hegedus ,  Gabor Gigler ,  Klara Reiter nee Esses ,  Aranka Lay nee Konya ,  Eva Furdyga ,  Istvan Gertyan ,  Istvan Gacsalyi

发明人： Zoltan Budai ,  Lujza Petocz ,  Tibor Mezei ,  Eniko Szirt nee Kiszelly ,  Maria Szecsey nee Hegedus ,  Gabor Gigler ,  Klara Reiter nee Esses ,  Aranka Lay nee Konya ,  Eva Furdyga ,  Istvan Gertyan ,  Istvan Gacsalyi

IPC分类号： A61K31/15 ,  A61K31/357 ,  A61K31/36 ,  A61K31/40 ,  A61P1/04 ,  A61P9/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/08 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07C249/04 ,  C07C249/08 ,  C07C251/44 ,  C07C251/58 ,  C07D295/08 ,  C07D295/088 ,  C07D317/58

CPC分类号： C07D295/088 ,  C07C251/44 ,  C07C2101/16

摘要： The new compounds of the general Formula I ##STR1## (wherein A stands for a C.sub.2-4 straight or branched chain alkylene group;R.sup.1 and R.sup.2 may be same or different and each stands for hydrogen, halogen, lower alkyl or lower alkoxy; orR.sup.1 and R.sup.2 together form a methylenedioxy group;R.sup.3 and R.sup.4 may be the same or different and each stands for C.sub.1.ident. alkyl or C.sub.3.notident. cycloalkyl orR.sup.3 and R.sup.4 together with the nitrogen atom, they are attached to, form a 4-7 membered ring which may contain as additional ring member an oxygen or sulfur atom or a further nitrogen atom and the latter nitrogen atom may optionally bear a C.sub.1-3 alkyl or benzyl substituent)and pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof possess valuable therapeutical properties and exert particularly useful transquillant-sedative, antidepressant, antiepileptic, antiparkinson, analgesic, local anaesthetic, gastric acid secretion inhibiting and/or antianginal effect.The new compounds of the general Formula I may be prepared by methods known per se.

摘要翻译： 通式I的新化合物（I）（其中A代表C2-4直链或支链亚烷基; R1和R2可以相同或不同，代表氢，卤素，低级烷基或低级） 烷氧基;或R 1和R 2一起形成亚甲二氧基; R 3和R 4可以相同或不同，并且各自代表C 1 =烷基或C 3或C 6的环烷基或R 3和R 4与氮原子一起形成4个 -7元环，其可以含有氧或硫原子或另外的氮原子作为附加的环成员，后一个氮原子可以任选地带有C 1-3烷基或苄基取代基）及其药学上可接受的酸加成盐和季铵盐具有 有价值的治疗性质，并且发挥特别有用的抗惊孕药，抗抑郁药，抗癫痫药，抗帕金森，止痛剂，局部麻醉剂，胃酸分泌抑制和/或抗心绞痛作用。 通式I的新化合物可以通过本身已知的方法制备。