公开(公告)号：US06645940B2

公开(公告)日：2003-11-11

申请号：US10313466

申请日：2002-12-06

申请人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Kimura ,  Shusuke Hashimoto

发明人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Kimura ,  Shusuke Hashimoto

IPC分类号： A61K3170

CPC分类号： C07H15/04

摘要： An oligosaccharide derivative, at higher homogeneity than fucose polysaccharide and rhamnose polysaccharide and with greater antiulcer effects, which is represented by the following general formula: Y—OCH(CH2NHR)2 wherein, Y represents an oligofucose or oligorhamnose at a polymerization number of 2 to 20, where the hydroxyl groups may or may not be partially modified in the form of sulfate ester, and R represents phenyl group, a higher alkylphenyl group, a higher alkyl group or —(CH2)n—NHX wherein n is an integer of 1 to 10 and X represents a higher alkanoyl group or an alkylamino group.

公开(公告)号：US06518249B1

公开(公告)日：2003-02-11

申请号：US09485978

申请日：2000-02-18

申请人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Kimura ,  Shusuke Hashimoto

发明人： Masato Nagaoka ,  Hideyuki Shibata ,  Itsuko Kimura ,  Shusuke Hashimoto

IPC分类号： A61K3170

CPC分类号： C07H15/04

摘要： An oligosaccharide derivative, at higher homogeneity than fucose polysaccharide and rhamnose polysaccharide and with greater antiulcer effects, which is represented by the following general formula: Y—OCH(CH2NHR)2 wherein, Y represents an oligofucose or oligorhamnose at a polymerization number of 2 to 20, where the hydroxyl groups may or may not be partially modified in the form of sulfate ester, and R represents phenyl group, a higher alkylphenyl group, a higher alkyl group or —(CH2)n—NHX wherein n is an integer of 1 to 10 and X represents a higher alkanoyl group or an alkylamino group.

摘要翻译： 一种低聚糖衍生物，其比岩藻糖多糖和鼠李糖多糖具有更高的均一性，并且具有较大的抗溃疡作用，其由以下通式表示：其中Y表示聚合数为2至20的寡聚核糖或寡鼠李糖，其中羟基可以 或可以不以硫酸酯的形式部分修饰，R代表苯基，高级烷基苯基，高级烷基或 - （CH2）n-NHX，其中n为1至10的整数，X表示较高的 烷酰基或烷基氨基。