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1.发明授权Inhibitors for replication of retroviruses and for the expression of oncogene products 失效抑制剂用于复制逆转录病毒和癌基因产物的表达
公开(公告)号：US5276019A
公开(公告)日：1994-01-04
申请号：US159017
申请日：1988-02-22
申请人： Jack S. Cohen , Len Neckers , Cy Stein , Shee L. Loke , Kazuo Shinozuka
发明人： Jack S. Cohen , Len Neckers , Cy Stein , Shee L. Loke , Kazuo Shinozuka
IPC分类号： A61K31/70 , A61K31/7088 , A61P31/12 , A61P35/00 , C07H21/00 , C07H21/04 , C12N15/113 , C12Q1/68 , C07H17/00
CPC分类号： A61K31/70 , C07H21/00 , C07H21/04 , C12N15/1132 , C12N2310/315 , C12N2310/335 , C12N2310/3521
摘要： Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
摘要翻译： 硫代磷酸寡脱氧核糖核苷酸类似物可用于防止外源核酸在正常活细胞存在下的复制，以及抑制肿瘤细胞的增殖。
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2.发明授权Inhibitors for replication of retroviruses and for the expression of oncogene products 失效抑制剂用于复制逆转录病毒和癌基因产物的表达
公开(公告)号：US5264423A
公开(公告)日：1993-11-23
申请号：US976733
申请日：1992-11-16
申请人： Jack S. Cohen , Len Neckers , Cy Stein , She L. Loke , Kazuo Shinozuka
发明人： Jack S. Cohen , Len Neckers , Cy Stein , She L. Loke , Kazuo Shinozuka
IPC分类号： C07H21/00 , C07H21/04 , C12N15/113 , A61K31/70 , C07H17/00
CPC分类号： A61K31/70 , C07H21/00 , C07H21/04 , C12N15/1132 , C12N2310/315 , C12N2310/335 , C12N2310/3521 , Y10S514/934
摘要： Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
摘要翻译： 硫代磷酸寡脱氧核糖核苷酸类似物可用于防止外源核酸在正常活细胞存在下的复制，以及抑制肿瘤细胞的增殖。
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3.发明授权Use of paramagnetic metalloporphyrins as contrast agents for tumors in MRI imaging 失效使用顺磁金属卟啉作为MRI成像中肿瘤的造影剂
公开(公告)号：US4986256A
公开(公告)日：1991-01-22
申请号：US706622
申请日：1985-02-28
申请人： Jack S. Cohen , Chi-Wan Chen , Charles E. Myers , Miriam Sohn
发明人： Jack S. Cohen , Chi-Wan Chen , Charles E. Myers , Miriam Sohn
CPC分类号： G01R33/5601 , A61K49/06 , Y10T436/24
摘要： Water-soluble paramagnetic metalloporphyrins are used as contrast enhancing agents for magnetic resonance imaging. These agents exhibit excellent localization, non-toxicity and suprisingly high contrast enhancement in magnetic resonance imaging applications.
摘要翻译： 水溶性顺磁性金属卟啉用作对比增强剂用于磁共振成像。 这些药物在磁共振成像应用中表现出优异的定位，无毒性和惊人的高对比度增强。
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公开(公告)号：US5286717A
公开(公告)日：1994-02-15
申请号：US976777
申请日：1992-11-16
申请人： Jack S. Cohen , Len Neckers , Cy Stein , She L. Loke , Kazuo Shinozuka
发明人： Jack S. Cohen , Len Neckers , Cy Stein , She L. Loke , Kazuo Shinozuka
IPC分类号： A61K31/70 , A61K31/7088 , A61P31/12 , A61P35/00 , C07H21/00 , C07H21/04 , C12N15/113 , C12Q1/68 , C07H17/00
CPC分类号： A61K31/70 , C07H21/00 , C07H21/04 , C12N15/1132 , C12N2310/315 , C12N2310/335 , C12N2310/3521
摘要： Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
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