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公开(公告)号：US07906130B2
公开(公告)日：2011-03-15
申请号：US11245579
申请日：2005-10-07
IPC分类号： A01N25/00 , A01N33/18 , A01N33/24 , A01N31/04 , C07C281/00 , C07D307/02
摘要： The present invention provides a stable composition which comprises a non-hydroxyl-group-containing solvent mixture comprising N,N-diethyl-m-toluamide and γ-hexalactone, optionally with dimethyl sulfoxide, eucalyptol and 1-methoxy-2-propyl acetate; and an effective amount of each of amitraz and at least one additional parasiticidal compound, such as R-28153. Said composition allows for high concentrations of a mixture of parasiticidal agents in a single application and is useful for treating and controlling parasiticidal infection and infestation in a homeothermic animal.
摘要翻译： 本发明提供一种稳定的组合物，其包含含有N，N-二乙基 - 间甲苯甲酰胺和γ-六乳酸内酯的非含羟基的溶剂混合物，任选地与二甲基亚砜，桉树脑和1-甲氧基-2-丙基乙酸酯; 和有效量的阿米他唑和至少一种另外的杀寄生虫化合物，例如R-28153。 所述组合物允许在单一应用中高浓度的杀寄生虫剂的混合物，并且可用于治疗和控制杀虫剂中的杀寄生虫感染和侵染。
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公开(公告)号：US5075295A
公开(公告)日：1991-12-24
申请号：US449652
申请日：1989-12-12
CPC分类号： A61K47/10 , A61K31/65 , A61K47/02 , A61K9/0014 , A61K9/0019
摘要： Novel aqueous oxytetracycline compositions comprising oxytetracycline, polyethylene glycol with a mean molecular weight of 400, and magnesium oxide. These compositions have good clarity and low viscosity.
摘要翻译： 包含土霉素，平均分子量为400的聚乙二醇和氧化镁的新型含水土霉素组合物。 这些组合物具有良好的透明度和低粘度。
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3.发明授权
公开(公告)号：US4440777A
公开(公告)日：1984-04-03
申请号：US280967
申请日：1981-07-07
申请人： Jacob A. Zupan
发明人： Jacob A. Zupan
CPC分类号： A61K47/22 , A61K9/0014 , Y10S514/946
摘要： Greatly enhanced delivery of a wide variety of bio-affecting agents is provided by formulations for topical application comprising at least one bio-affecting agent and eucalyptol. Optionally, the formulation can further comprise a non-toxic topical carrier and/or an additional penetration enhancer. The eucalyptol acts as a unique transport agent which readily delivers the active bio-affecting agent across the stratum corneum to the target area. Cosmetic and therapeutic dermatological agents as well as systemically effective therapeutic agents can be easily formulated with eucalyptol and effectively delivered through the skin to the desired site, i.e., to the underlying tissues of the epidermis and dermis or to the general circulation.
摘要翻译： 通过包含至少一种生物影响剂和桉树脑的局部施用的制剂提供各种各样的生物影响剂的极大增强的递送。 任选地，制剂还可以包含无毒的局部载体和/或另外的渗透增强剂。 桉树脑作为独特的运输剂，其易于将活性生物影响剂跨越角质层递送至目标区域。 化妆品和治疗性皮肤病药物以及系统有效的治疗剂可以容易地与桉树脑配制，并且有效地通过皮肤递送到所需部位，即表皮和真皮的底层组织或一般循环。
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4.发明授权Novel process and intermediates useful in the preparation of sympathomimetic amines 失效用于制备拟交感胺的新型方法和中间体
公开(公告)号：US4338455A
公开(公告)日：1982-07-06
申请号：US233457
申请日：1981-02-11
申请人： Jacob A. Zupan
发明人： Jacob A. Zupan
IPC分类号： C07C271/06 , C07C125/065
CPC分类号： C07C271/06 , Y02P20/55
摘要： The invention relates to a novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) can be prepared in optically active or racemic form by reacting the corresponding mono- or dihydroxy aromatic amine with a reagent capable of forming the N-tert-butoxycarbonyl derivative thereof; reacting the novel intermediate thus obtained with an acyloxymethyl chloride to afford the corresponding novel mono- or diacylated N-protected aromatic amine; and removing the N-protecting group therefrom.
摘要翻译： 本发明涉及可用于拟交感神经胺的新方法和新型中间体。 作为单 - 和二羟基芳族胺（例如儿茶酚胺）的酰基衍生物的药理学上有用的最终产物可以通过使相应的一羟基或二羟基芳族胺与能够形成N的试剂反应，以光学活性或外消旋形式制备 - 叔丁氧羰基衍生物; 将由此获得的新型中间体与酰氧基甲基氯反应，得到相应的新的单酰基或二酰化N-保护的芳族胺; 并从其中除去N-保护基。
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5.发明授权Novel process and intermediates useful in the preparation of sympathomimetic amines 失效用于制备拟交感胺的新型方法和中间体
公开(公告)号：US4275219A
公开(公告)日：1981-06-23
申请号：US78197
申请日：1979-09-24
申请人： Jacob A. Zupan
发明人： Jacob A. Zupan
IPC分类号： C07C271/16 , C07C67/00 , C07C239/00 , C07C271/06 , C07C309/63 , C07C125/065 , C07C69/017
CPC分类号： C07C271/06 , C07C309/63 , Y02P20/55
摘要： The invention relates to a novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) can be prepared in optically active or racemic form by reacting the corresponding mono- or dihydroxy aromatic amine with a reagent capable of forming the N-tert-butoxycarbonyl derivative thereof; reacting the novel intermediate thus obtained with an acyloxymethyl chloride to afford the corresponding novel mono- or diacylated N-protected aromatic amine; and removing the N-protecting group therefrom.
摘要翻译： 本发明涉及可用于拟交感神经胺的新方法和新型中间体。 作为单 - 和二羟基芳族胺（例如儿茶酚胺）的酰基衍生物的药理学上有用的最终产物可以通过使相应的一羟基或二羟基芳族胺与能够形成N的试剂反应，以光学活性或外消旋形式制备 - 叔丁氧羰基衍生物; 将由此获得的新型中间体与酰氧基甲基氯反应，得到相应的新的单酰基或二酰化N-保护的芳族胺; 并从其中除去N-保护基。
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公开(公告)号：US07687471B2
公开(公告)日：2010-03-30
申请号：US11634027
申请日：2006-12-05
申请人： Jon C. Hayes , Debora L. Guido , Jacob A. Zupan
发明人： Jon C. Hayes , Debora L. Guido , Jacob A. Zupan
CPC分类号： A61K9/0095 , A61K31/365 , A61K31/4184 , A61K45/06 , A61K2300/00
摘要： The present invention provides a stable veterinary oral composition which comprises one or more surfactants, a water-miscible solvent, optionally an oil and an effective amount of each of a benzimidazole antihelmintic compound, such as triclabendazole and a macrocyclic lactone, such as moxidectin. Said composition is useful for treating and controlling endo- and ectoparasitic infection and infestation in a homeothermic animal.
摘要翻译： 本发明提供一种稳定的兽用口服组合物，其包含一种或多种表面活性剂，水混溶性溶剂，任选的油和有效量的苯并咪唑类抗真菌化合物如三氯苯达唑和大环内酯如莫昔克丁。 所述组合物可用于治疗和控制驯养动物体内外寄生虫感染和寄生虫感染。
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7.发明授权
公开(公告)号：US4560553A
公开(公告)日：1985-12-24
申请号：US554026
申请日：1983-11-21
申请人： Jacob A. Zupan
发明人： Jacob A. Zupan
IPC分类号： A61K47/22 , A61K31/025 , A61K31/075 , A61K31/135 , A61K31/195 , A61K31/205 , A61K31/245 , A61K31/335 , A61K31/415 , A61K31/43 , A61K31/44 , A61K31/52 , A61K31/54 , A61K31/65 , A61K31/70 , A61K31/71
CPC分类号： A61K9/0014 , A61K47/22 , Y10S514/853
摘要： Eucalyptol is used to enhance skin permeation of bio-affecting agents.
摘要翻译： 桉树脑用于增强生物影响剂的皮肤渗透。
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