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    Nasal hygiene method and composition
    6.
    发明申请
    Nasal hygiene method and composition 失效
    鼻子卫生方法和组成

    公开(公告)号：US20040071788A1

    公开(公告)日：2004-04-15

    申请号：US10630453

    申请日：2003-07-30

    发明人： Allan H. Fuhr

    IPC分类号： A61K033/14

    CPC分类号： A61K33/06 ,  A61K33/14 ,  A61K33/40 ,  Y10S514/853 ,  A61K2300/00

    摘要： A method is disclosed of practicing nasal hygiene comprising the steps of applying to a person's nostril a non-irritating hygienic composition consisting essentially of a product of compounding under homogenizing conditions water, 0.01% to 5% by weight, as chlorine dioxide, of a source of chlorine dioxide; 0.01% to 3% by weight of at least one olfactory stimulant, 0 to 5% by weight of at least one fixative compound less volatile than the olfactory stimulant 0.1 to 2.5% by weight of at least one inorganic salt selected from the group consisting of alkali metal chloride, alkali metal bicarbonate, and alkali metal chlorate; and 0.0002 to 0.006% (as aluminum) by weight of at least one water soluble aluminum compound, provided that the total concentration of inorganic salt is in the range from 0.6% by weight to 2.5% by weight, holding the composition within the nostril for a hygienic holding period, and discharging the composition from the treated nostril.

    摘要翻译： 公开了实施鼻腔卫生的方法，其包括以下步骤：向人鼻孔施用无刺激性卫生组合物的步骤，所述组合物基本上由在均匀化条件下混合的产物组成，所述产品在0.01％至5％重量的水中作为二氧化氯，源 的二氧化氯; 至少一种嗅觉刺激剂，至少一种嗅觉兴奋剂，至少一种至少一种比嗅觉兴奋剂挥发性更低的固定化合物为0.1至2.5重量％的至少一种嗅觉兴奋剂，至少一种选自以下的无机盐： 碱金属氯化物，碱金属碳酸氢盐和碱金属氯酸盐; 和至少一种水溶性铝化合物的0.0002至0.006％（以铝计），条件是无机盐的总浓度在0.6重量％至2.5重量％的范围内，将组合物保持在鼻孔内 卫生持有期间，并从经处理的鼻孔排出组合物。

    Spray composition
    7.
    发明申请
    Spray composition 有权
    喷雾成分

    公开(公告)号：US20030185763A1

    公开(公告)日：2003-10-02

    申请号：US10391712

    申请日：2003-03-19

    发明人： Joseph A. Haslwanter ,  William J. McLaughlin ,  David M. Oakley ,  Kurt G. Van Scoik

    IPC分类号： A61L009/04

    CPC分类号： A61K31/4174 ,  A61K9/0043 ,  Y10S514/853

    摘要： An aqueous-based sprayable composition comprises a therapeutic or palliative agent, water and a mixture of microcrystalline cellulose and alkali metal carboxyalkylcellulose. In one embodiment, the composition is a non-Newtonian nasal spray exhibiting a very rapid viscosity recovery upon removal of shear forces.

    摘要翻译： 水性可喷雾组合物包含治疗性或缓和剂，水和微晶纤维素和碱金属羧烷基纤维素的混合物。 在一个实施方案中，组合物是在去除剪切力时表现出非常快速的粘度恢复的非牛顿鼻喷雾剂。

    Pharmaceutical composition for combination of piperidinoalkanol-decongestant
    9.
    发明授权
    Pharmaceutical composition for combination of piperidinoalkanol-decongestant 失效
    用于组合哌啶基链烷醇 - 减充血剂的药物组合物

    公开(公告)号：US6039974A

    公开(公告)日：2000-03-21

    申请号：US127478

    申请日：1998-07-31

    申请人： David D. MacLaren ,  John R. Lefler ,  Sharon K. Minish

    发明人： David D. MacLaren ,  John R. Lefler ,  Sharon K. Minish

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/24 ,  A61K31/445 ,  A61K45/00 ,  A61K45/06 ,  A61K47/04 ,  A61K47/12 ,  A61K47/38 ,  A61K47/44 ,  A61P11/02 ,  A61P11/08 ,  A61P37/08 ,  A61P43/00 ,  A61K9/28

    CPC分类号： A61K9/209 ,  A61K31/445 ,  A61K9/2013 ,  A61K9/2054 ,  Y10S514/853

    摘要： The present invention provides a pharmaceutical composition in the form of a bilayer tablet comprising,(a) a first discrete zone made with Formulation (A) which comprises, a therapeutically effective decongestant amount of a sympathomimetic drug, or a pharmaceutically acceptable salt thereof, in an amount of about 18% to about 39% by weight of Formulation (A), and a first carrier base material, the first carrier base material comprising a mixture of;(I) carnauba wax in an amount of about 59% to about 81% by weight of Formulation (A); and(ii) a suitable antiadherent in an amount of about 0.25% to about 2.00% by weight of Formulation (A);wherein said first carrier base material provides a sustained release of the sympathomimetic drug; and(b) a second discrete zone made with Formulation (B) which comprises a therapeutically effective antihistaminic amount of a piperidinoalkanol, or a pharmaceutically acceptable salt thereof, in an amount of about 15% to about 30% by weight of Formulation (B) and a second carrier base material, the second carrier base comprising a mixture of;(I) a cellulose diluent in an amount of about 27% to about 73% by weight of Formulation (B);(ii) pregelatinized starch in an amount of about 15% to about 30% by weight of Formulation (B);(iii) a suitable disintegrant in an amount of about 0.25% to about 6.00% by weight of Formulation (B); and(iv) a suitable lubricant in an amount of about 0.25% to about 2.00% by weight of Formulation (B);wherein said second carrier base material provides an immediate release of the piperidinoalkanol or the pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供了一种双层片剂形式的药物组合物，其包含：（a）由制剂（A）制成的第一离散区，其包含治疗有效的减充血剂量的拟交感神经药物或其药学上可接受的盐， 约占制剂（A）的约18重量％至约39重量％的第一载体基材，第一载体基材包含混合物; （I）巴西棕榈蜡的量为制剂（A）的约59％至约81％重量; 和（ii）配方（A）的约0.25重量％至约2.00重量％的合适的抗粘附剂; 其中所述第一载体基材提供所述拟交感神经药物的持续释放; （B）由制剂（B）制成的第二离散区，其包含治疗有效的抗组胺量的哌啶子基链烷醇或其药学上可接受的盐，其量为制剂（B）的约15重量％至约30重量％ 和第二载体基材，所述第二载体基底包括： （I）配方（B）的约27％至约73％重量的纤维素稀释剂; （ii）预胶化淀粉，其量为制剂（B）的约15重量％至约30重量％; （iii）配方（B）的约0.25％至约6.00％重量的合适的崩解剂; 和（iv）配方（B）的约0.25％至约2.00％重量的合适润滑剂; 其中所述第二载体基料提供哌啶子基链烷醇或其药学上可接受的盐的即时释放。