公开(公告)号：US06410513B1

公开(公告)日：2002-06-25

申请号：US09573809

申请日：2000-05-18

申请人： John A. Galloway ,  James A. Hoffman

发明人： John A. Galloway ,  James A. Hoffman

IPC分类号： A61K3800

CPC分类号： C07K14/605 ,  A61K38/00 ,  A61K47/62 ,  Y10S514/866 ,  Y10S977/773 ,  Y10S977/904 ,  Y10S977/915

摘要： The present invention provides novel complexes consisting of certain GLP-1 molecules associated with a divalent metal cation that is capable of co-precipitating with a GLP-1 molecule. Pharmaceutical compositions and methods of using such complexes for enhancing the expression of insulin in B-type islet cells is claimed, as is a method for treating maturity onset diabetes mellitus in mammals, particularly humans.

摘要翻译： 本发明提供由能够与GLP-1分子共沉淀的二价金属阳离子相关联的某些GLP-1分子组成的新型复合物。 要求使用这种复合物来增强B型胰岛细胞中胰岛素表达的药物组合物和方法，以及用于治疗哺乳动物，特别是人类中成熟起始糖尿病的方法。

公开(公告)号：US5569743A

公开(公告)日：1996-10-29

申请号：US381054

申请日：1995-01-31

申请人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffman ,  James E. Shields ,  David L. Smiley

发明人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffman ,  James E. Shields ,  David L. Smiley

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/00

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.