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1.发明申请PROCESS FOR PREPARING INTERMEDIATES USEFUL TO PREPARE CERTAIN ANTIBACTERIAL N-FORMYL HYDROXYLAMINES 审中-公开制备中间体的方法可用于制备某些抗菌N-甲酰羟胺公开(公告)号：US20090118515A1
公开(公告)日：2009-05-07
申请号：US12263992
申请日：2008-11-03
IPC分类号： C07D401/12 , C07D263/20 , C07C51/373
CPC分类号： C07D401/12 , C07C239/20 , C07C259/06 , C07D263/26 , C07F7/1892
摘要： The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors.
摘要翻译： 本发明涉及一种制备中间体的方法，其可用于制备作为肽去甲酰化酶抑制剂的某些抗菌N-甲酰基羟胺化合物。
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公开(公告)号：US09365565B2
公开(公告)日：2016-06-14
申请号：US14232717
申请日：2012-07-12
申请人： Wolfgang Marterer , Mahavir Prashad , Edwin Bernard Villhauer , Liladhar Murlidhar Waykole , James Anthony Vivelo , Bertrand Sutter , Jean-Claude Bianchi , Raeann Wu , Denis Har , Piotr H. Karpinski , Massimo Pignone , Doris Stingelin , Eckart Buerger
发明人： Wolfgang Marterer , Mahavir Prashad , Edwin Bernard Villhauer , Liladhar Murlidhar Waykole , James Anthony Vivelo , Bertrand Sutter , Jean-Claude Bianchi , Raeann Wu , Denis Har , Piotr H. Karpinski , Massimo Pignone , Doris Stingelin , Eckart Buerger
IPC分类号： A61K9/20 , C07D453/02 , A61K31/194 , A61K31/439 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15
CPC分类号： C07D453/02 , A61K9/2054 , A61K31/194 , A61K31/439 , A61K2300/00 , C07B2200/07 , C07B2200/13 , C07C51/412 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15
摘要： The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.
摘要翻译： 本发明涉及（R）-3-（6-（4-甲基苯基） - 吡啶-3-基氧基）-1-氮杂 - 双环[2.2.2]辛烷的盐，其制备方法或其前体， 包含它们的药物组合物以及它们作为药物的用途。
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公开(公告)号：US20080221336A1
公开(公告)日：2008-09-11
申请号：US11995261
申请日：2006-07-12
申请人： Christine E. Garrett , Guang-Pei Chen , George Tien-San Lee , Xinglong Jiang , Michael J. Girgis , James Anthony Vivelo , Beata Sweryda-Krawiec , Dimitris Papoutsakis , Piotr Karpinski , Prasad Koteswara Kapa , Ada Skorodinsky
发明人： Christine E. Garrett , Guang-Pei Chen , George Tien-San Lee , Xinglong Jiang , Michael J. Girgis , James Anthony Vivelo , Beata Sweryda-Krawiec , Dimitris Papoutsakis , Piotr Karpinski , Prasad Koteswara Kapa , Ada Skorodinsky
IPC分类号： C07D263/32
CPC分类号： C07D413/12
摘要： This invention provides a method for preparing compounds having the structure [Formula (I)] wherein L is [Formula (A)] or [Formula (B)] in which R1 is hydrogen or optionally substituted alkyl, n is zero or 1 and m is 1; wherein R is H, halogen, optionally substituted C1-6alkyl or C1-6alkoxy; wherein Z is a bond, O or S; wherein p is an integer from 1 to 5; wherein Q is a bond provided that Z is not a bond when p is 1; or Q is O, S or —C(O)NR6— in which R6 is hydrogen, optionally substituted alkyl or cycloalkyl; or Q is —NR6—, —NR5C(O)NH— or —NR5C(O)O— in which R5 is hydrogen, alkyl or aralkyl provided that p is not 1; wherein W is cycloalkyl, aryl or heterocyclyl; or W and R6 form a 9- to 10-membered bicyclic ring, which may be optionally substituted or may contain oxygen, nitrogen or sulfur.
摘要翻译： 本发明提供了制备具有结构[式（I）]的化合物的方法，其中L是[式（A）]或[式（B）]，其中R 1是氢或任选取代的烷基 ，n为0或1，m为1; 其中R是H，卤素，任选取代的C 1-6烷基或C 1-6烷氧基; 其中Z是键，O或S; 其中p是1至5的整数; 其中Q是键，条件是当p是1时Z不是键; 或Q是O，S或-C（O）NR 6 - ，其中R 6是氢，任选取代的烷基或环烷基; 或Q是-NR 6 - ， - NR 5 C（O）NH-或-NR 5 C（O）O-，其中 R 5是氢，烷基或芳烷基，条件是p不是1; 其中W是环烷基，芳基或杂环基; 或W和R 6形成9至10元双环，其可任选被取代或可含有氧，氮或硫。
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4.发明申请SALTS OF AZA-BICYCLIC DI-ARYL ETHERS AND METHODS TO MAKE THEM OR THEIR PRECURSORS 有权AZA-BICYCLIC DI-ARYL ETHERS的价格及其制造方法或其前身公开(公告)号：US20140220125A1
公开(公告)日：2014-08-07
申请号：US14232717
申请日：2012-07-12
申请人： Wolfgang Marterer , Mahavir Prashad , Edwin Bernard Villhauer , Liladhar Murlidhar Waykole , James Anthony Vivelo , Bertrand Sutter , Jean-Claude Bianchi , Raeann Wu , Denis Har , Piotr H. Karpinski , Massimo Pignone , Doris Stingelin , Eckart Buerger
发明人： Wolfgang Marterer , Mahavir Prashad , Edwin Bernard Villhauer , Liladhar Murlidhar Waykole , James Anthony Vivelo , Bertrand Sutter , Jean-Claude Bianchi , Raeann Wu , Denis Har , Piotr H. Karpinski , Massimo Pignone , Doris Stingelin , Eckart Buerger
IPC分类号： C07D453/02 , C07C57/15 , A61K31/194 , C07C55/10 , C07C55/08 , A61K31/439 , C07C57/145
CPC分类号： C07D453/02 , A61K9/2054 , A61K31/194 , A61K31/439 , A61K2300/00 , C07B2200/07 , C07B2200/13 , C07C51/412 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15
摘要： The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.
摘要翻译： 本发明涉及（R）-3-（6-（4-甲基苯基） - 吡啶-3-基氧基）-1-氮杂 - 双环[2.2.2]辛烷的盐，其制备方法或其前体， 包含它们的药物组合物以及它们作为药物的用途。
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