-
公开(公告)号：US5502164A
公开(公告)日：1996-03-26
申请号：US294203
申请日：1994-08-22
IPC分类号： A61K38/00 , C07K14/595 , C07K7/00 , C07K7/06
CPC分类号： C07K14/5955 , C07K14/595 , A61K38/00
摘要： Compounds of formula I, ##STR1## wherein M is Met, DMet, MeMet, MetO, Ahx, DAhx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys, G is Gly, DAla, Pro, Ala, .beta.Ala or Sar; W is Trp, MeTrp, Ala or Nal; X is Met, MeMet, MetO, Ahx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala, Phe, Lys or Lys(R.sup.8); J is Asp, DAsp, MeAsp, Asp(OBn), Ala or MeDAsp; F.sup.1 is (S)--NH, (R)--NH, (S)--R.sup.1 N or (R)--R.sup.2 N; F.sup.2 is H, Cl, I, Br, F, NO.sub.2, NH.sub.2, R.sup.3 or OR.sup.4 ; Z is NH.sub.2, NHR.sup.5 or NR.sup.5 R.sup.6 ; R.sup.1, R.sup.2, R.sup.3, R.sup.5 and R.sup.6 are alkyl C.sub.1-6 ; R.sup.4 is H or alkyl C.sub.1-4 ; R.sup. is OH or OSO.sub.3 H; and pharmaceutically acceptable derivatives thereof; are useful as therapeutic agents, in particular in the inhibition of feeding.
摘要翻译： 式I化合物，其中M为Met，DMet，MeMet，MetO，Ahx，DAhx，MeAhx，Leu，MeLeu，Pro，Ile，MeIle，Ala或Lys，G为Gly，DAla，Pro， βAla或Sar; W是Trp，MeTrp，Ala或Nal; X是Met，MeMet，MetO，Ahx，MeAhx，Leu，MeLeu，Pro，Ile，MeIle，Ala，Phe，Lys或Lys（R8） J是Asp，DAsp，MeAsp，Asp（OBn），Ala或MeDAsp; F1是（S）-NH，（R）-NH，（S）-R1N或（R）-R2N; F2是H，Cl，I，Br，F，NO2，NH2，R3或OR4; Z是NH 2，NHR 5或NR 5 R 6; R1，R2，R3，R5和R6是烷基C1-6; R4是H或C1-4烷基; Ris OH或OSO3H; 及其药学上可接受的衍生物; 可用作治疗剂，特别是抑制喂养。
-
公开(公告)号：US5086042A
公开(公告)日：1992-02-04
申请号：US303425
申请日：1989-01-26
申请人： James D. Rosamond
发明人： James D. Rosamond
CPC分类号： C07K14/5955 , C07K14/595 , A61K38/00
摘要： Novel peptides having sulfate ester groups and containing 6 to 9 amino acids; possessing feeding inhibition properties and capable of stimulating the contraction of the gallbladder. Also methods of treating and preventing obesity in which these novel peptides or other specified peptides can be used.
摘要翻译： 具有硫酸酯基并含有6至9个氨基酸的新肽; 具有抑制食物的能力，能够刺激胆囊的收缩。 还可以使用这些新型肽或其它特定肽的治疗和预防肥胖的方法。
-
3.发明授权Process for the solid phase synthesis of peptides which contain sulfated tyrosine 失效含有硫酸化酪氨酸的肽的固相合成方法
公开(公告)号：US4769445A
公开(公告)日：1988-09-06
申请号：US129379
申请日：1987-11-24
申请人： Jeanne Comstock , James D. Rosamond
发明人： Jeanne Comstock , James D. Rosamond
IPC分类号： C07K1/00 , C07K1/04 , C07K14/595 , A61K37/02
CPC分类号： C07K1/006 , C07K1/04 , C07K1/042 , C07K14/595 , Y10S930/28
摘要： Peptides and Peptide amides such as cholecystokinin (CCK-8) are synthesized in improved yields and purity by a solid phase process. The requisite protected peptide is elaborated and sulfated on a solid support, deprotected, and cleaved from the solid support to give the total synthesis of CCK-8 on a solid support. Thereafter, the peptide is purified in a single step by ion exchange chromatography to provide analytically pure CCK-8.
摘要翻译： 肽和肽酰胺如缩胆囊素（CCK-8）通过固相方法以提高的产率和纯度合成。 将必需的保护肽在固体支持物上精制和硫酸化，脱保护并从固体支持物上切割，得到固体支持物上CCK-8的全合成。 此后，通过离子交换色谱法在一个步骤中纯化肽以提供分析纯的CCK-8。
-
-
搜索结果
3 条记录 (耗时 0.013 秒)
